{
  "url": "https://dantelabs.com/traits/abnormal-dermoepidermal-junction-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-dermoepidermal-junction-morphology",
    "id": "HP:0031538",
    "name": "Abnormal dermoepidermal junction morphology",
    "definition": "Any anomaly of the structure of the acellular zone that is between the dermis and the epidermis and which functions to bind the epidermis to the dermis and to serve as a selective barrier allowing the control of molecular and cellular exchanges between the two compartments.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-skin-morphology",
        "name": "Abnormal skin structure",
        "url": "https://dantelabs.com/traits/abnormal-skin-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-dermoepidermal-hemidesmosome-morphology",
        "name": "Abnormal dermoepidermal hemidesmosome morphology",
        "genes": 3,
        "url": "https://dantelabs.com/traits/abnormal-dermoepidermal-hemidesmosome-morphology"
      },
      {
        "slug": "linear-igg-deposits-along-the-epidermal-basement-membrane-zone",
        "name": "Linear IgG deposits along the epidermal basement membrane zone",
        "genes": 1,
        "url": "https://dantelabs.com/traits/linear-igg-deposits-along-the-epidermal-basement-membrane-zone"
      }
    ],
    "genes": [
      {
        "slug": "dsp",
        "symbol": "DSP",
        "hgnc": "HGNC:3052",
        "name": "desmoplakin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsp"
      },
      {
        "slug": "jup",
        "symbol": "JUP",
        "hgnc": "HGNC:6207",
        "name": "junction plakoglobin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jup"
      }
    ]
  }
}