{
  "url": "https://dantelabs.com/traits/abnormal-csf-metabolite-concentration",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "abnormal-csf-metabolite-concentration",
    "id": "HP:0025454",
    "name": "Abnormal CSF metabolite concentration",
    "definition": "Any deviation from the normal range of concentration of a metabolite in the cerebrospinal fluid.",
    "synonyms": [
      "Abnormal cerebrospinal fluid metabolite concentration",
      "Abnormal CSF metabolite level"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-cerebrospinal-fluid-morphology",
        "name": "Abnormal cerebrospinal fluid morphology",
        "url": "https://dantelabs.com/traits/abnormal-cerebrospinal-fluid-morphology"
      },
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "narrower": [
      {
        "slug": "increased-csf-interferon-alpha",
        "name": "Increased CSF interferon alpha",
        "genes": 9,
        "url": "https://dantelabs.com/traits/increased-csf-interferon-alpha"
      },
      {
        "slug": "decreased-csf-5-hydroxyindolacetic-acid-concentration",
        "name": "Decreased CSF 5-hydroxyindolacetic acid concentration",
        "genes": 4,
        "url": "https://dantelabs.com/traits/decreased-csf-5-hydroxyindolacetic-acid-concentration"
      },
      {
        "slug": "abnormal-csf-lactate-concentration",
        "name": "Abnormal CSF lactate concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-csf-lactate-concentration"
      },
      {
        "slug": "decreased-csf-creatinine-concentration",
        "name": "Decreased CSF creatinine concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/decreased-csf-creatinine-concentration"
      },
      {
        "slug": "decreased-csf-erythritol-concentration",
        "name": "Decreased CSF erythritol concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/decreased-csf-erythritol-concentration"
      },
      {
        "slug": "elevated-csf-cholestanol-concentration",
        "name": "Elevated CSF cholestanol concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/elevated-csf-cholestanol-concentration"
      },
      {
        "slug": "elevated-csf-dihydrouracil-concentration",
        "name": "Elevated CSF dihydrouracil concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/elevated-csf-dihydrouracil-concentration"
      },
      {
        "slug": "elevated-csf-fumarate-concentration",
        "name": "Elevated CSF fumarate concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/elevated-csf-fumarate-concentration"
      },
      {
        "slug": "elevated-csf-n-carbamyl-beta-alanine-concentration",
        "name": "Elevated CSF N-carbamyl-beta-alanine concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/elevated-csf-n-carbamyl-beta-alanine-concentration"
      },
      {
        "slug": "elevated-csf-n-carbamyl-beta-aminoisobutyric-acid-concentration",
        "name": "Elevated CSF N-carbamyl-beta-aminoisobutyric acid concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/elevated-csf-n-carbamyl-beta-aminoisobutyric-acid-concentration"
      },
      {
        "slug": "increased-csf-d-threitol-concentration",
        "name": "Increased CSF D-threitol concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/increased-csf-d-threitol-concentration"
      },
      {
        "slug": "increased-csf-n-acetylaspartic-acid-concentration",
        "name": "Increased CSF N-acetylaspartic acid concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/increased-csf-n-acetylaspartic-acid-concentration"
      },
      {
        "slug": "increased-csf-ribitol-concentration",
        "name": "Increased CSF ribitol concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/increased-csf-ribitol-concentration"
      },
      {
        "slug": "increased-csf-ribose-concentration",
        "name": "Increased CSF ribose concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/increased-csf-ribose-concentration"
      },
      {
        "slug": "increased-csf-xylitol-concentration",
        "name": "Increased CSF xylitol concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/increased-csf-xylitol-concentration"
      },
      {
        "slug": "abnormal-csf-carboxylic-acid-concentration",
        "name": "Abnormal CSF carboxylic acid concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-csf-carboxylic-acid-concentration"
      },
      {
        "slug": "abnormal-csf-folate-concentration",
        "name": "Abnormal CSF folate concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-csf-folate-concentration"
      },
      {
        "slug": "abnormal-csf-glucose-concentration",
        "name": "Abnormal CSF glucose concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-csf-glucose-concentration"
      },
      {
        "slug": "abnormal-csf-homovanillic-acid-concentration",
        "name": "Abnormal CSF homovanillic acid concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-csf-homovanillic-acid-concentration"
      },
      {
        "slug": "abnormal-csf-neopterin-concentration",
        "name": "Abnormal CSF neopterin concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-csf-neopterin-concentration"
      },
      {
        "slug": "abnormal-csf-pterin-concentration",
        "name": "Abnormal CSF pterin concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-csf-pterin-concentration"
      }
    ],
    "genes": []
  }
}