{
  "url": "https://dantelabs.com/traits/abnormal-cranial-nerve-morphology",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-cranial-nerve-morphology",
    "id": "HP:0001291",
    "name": "Abnormal cranial nerve morphology",
    "definition": "Structural abnormality affecting one or more of the cranial nerves, which emerge directly from the brain stem.",
    "synonyms": [
      "Abnormality of cranial nerve",
      "Abnormality of the cranial nerves",
      "Cranial nerve disease",
      "Cranial nerve involvement"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-peripheral-nervous-system-morphology",
        "name": "Abnormal peripheral nervous system structure",
        "url": "https://dantelabs.com/traits/abnormal-peripheral-nervous-system-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "cranial-nerve-compression",
        "name": "Cranial nerve compression",
        "genes": 31,
        "url": "https://dantelabs.com/traits/cranial-nerve-compression"
      },
      {
        "slug": "abnormal-vestibulocochlear-nerve-morphology",
        "name": "Abnormal vestibulocochlear nerve morphology",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-vestibulocochlear-nerve-morphology"
      },
      {
        "slug": "abnormality-of-the-eleventh-cranial-nerve",
        "name": "Abnormality of the eleventh cranial nerve",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormality-of-the-eleventh-cranial-nerve"
      },
      {
        "slug": "cranial-nerve-motor-loss",
        "name": "Cranial nerve motor loss",
        "genes": 1,
        "url": "https://dantelabs.com/traits/cranial-nerve-motor-loss"
      }
    ],
    "genes": [
      {
        "slug": "chd7",
        "symbol": "CHD7",
        "hgnc": "HGNC:20626",
        "name": "chromodomain helicase DNA binding protein 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd7"
      },
      {
        "slug": "fgf3",
        "symbol": "FGF3",
        "hgnc": "HGNC:3681",
        "name": "fibroblast growth factor 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgf3"
      },
      {
        "slug": "otx2",
        "symbol": "OTX2",
        "hgnc": "HGNC:8522",
        "name": "orthodenticle homeobox 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otx2"
      },
      {
        "slug": "prrx1",
        "symbol": "PRRX1",
        "hgnc": "HGNC:9142",
        "name": "paired related homeobox 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prrx1"
      },
      {
        "slug": "sema3e",
        "symbol": "SEMA3E",
        "hgnc": "HGNC:10727",
        "name": "semaphorin 3E",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sema3e"
      },
      {
        "slug": "slc29a3",
        "symbol": "SLC29A3",
        "hgnc": "HGNC:23096",
        "name": "solute carrier family 29 member 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc29a3"
      },
      {
        "slug": "tcirg1",
        "symbol": "TCIRG1",
        "hgnc": "HGNC:11647",
        "name": "T cell immune regulator 1, ATPase H+ transporting V0 subunit a3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcirg1"
      },
      {
        "slug": "tnfrsf11a",
        "symbol": "TNFRSF11A",
        "hgnc": "HGNC:11908",
        "name": "TNF receptor superfamily member 11a",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf11a"
      },
      {
        "slug": "ankh",
        "symbol": "ANKH",
        "hgnc": "HGNC:15492",
        "name": "ANKH inorganic pyrophosphate transport regulator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ankh"
      },
      {
        "slug": "gdf3",
        "symbol": "GDF3",
        "hgnc": "HGNC:4218",
        "name": "growth differentiation factor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdf3"
      },
      {
        "slug": "gdf6",
        "symbol": "GDF6",
        "hgnc": "HGNC:4221",
        "name": "growth differentiation factor 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdf6"
      },
      {
        "slug": "gja1",
        "symbol": "GJA1",
        "hgnc": "HGNC:4274",
        "name": "gap junction protein alpha 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja1"
      },
      {
        "slug": "gnaq",
        "symbol": "GNAQ",
        "hgnc": "HGNC:4390",
        "name": "G protein subunit alpha q",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnaq"
      },
      {
        "slug": "meox1",
        "symbol": "MEOX1",
        "hgnc": "HGNC:7013",
        "name": "mesenchyme homeobox 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/meox1"
      },
      {
        "slug": "nod2",
        "symbol": "NOD2",
        "hgnc": "HGNC:5331",
        "name": "nucleotide binding oligomerization domain containing 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nod2"
      },
      {
        "slug": "egr2",
        "symbol": "EGR2",
        "hgnc": "HGNC:3239",
        "name": "early growth response 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/egr2"
      },
      {
        "slug": "sh3tc2",
        "symbol": "SH3TC2",
        "hgnc": "HGNC:29427",
        "name": "SH3 domain and tetratricopeptide repeats 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sh3tc2"
      }
    ]
  }
}