{
  "url": "https://dantelabs.com/traits/abnormal-circulating-tryptophan-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-tryptophan-concentration",
    "id": "HP:0004365",
    "name": "Abnormal circulating tryptophan concentration",
    "definition": "Any deviation from the normal concentration of tryptophan in the blood circulation.",
    "synonyms": [
      "Abnormal tryptophan level",
      "Abnormality of tryptophan metabolism"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-aromatic-amino-acid-concentration",
        "name": "Abnormal circulating aromatic amino acid concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-aromatic-amino-acid-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "hypertryptophanemia",
        "name": "High blood tryptophan concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/hypertryptophanemia"
      }
    ],
    "genes": [
      {
        "slug": "kynu",
        "symbol": "KYNU",
        "hgnc": "HGNC:6469",
        "name": "kynureninase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kynu"
      }
    ]
  }
}