{
  "url": "https://dantelabs.com/traits/abnormal-circulating-icosanoid-concentration",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-icosanoid-concentration",
    "id": "HP:0030361",
    "name": "Abnormal circulating icosanoid concentration",
    "definition": "Any deviation from the normal concentration of icosanoid in the blood circulation.",
    "synonyms": [
      "Abnormal icosanoid level",
      "Abnormality of icosanoid metabolism"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-unsaturated-fatty-acid-concentration",
        "name": "Abnormal circulating unsaturated fatty acid concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-unsaturated-fatty-acid-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "reduced-circulating-leukotriene-c4-concentration",
        "name": "Reduced circulating leukotriene C4 concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/reduced-circulating-leukotriene-c4-concentration"
      },
      {
        "slug": "abnormal-circulating-prostaglandin-concentration",
        "name": "Abnormal circulating prostaglandin concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-prostaglandin-concentration"
      },
      {
        "slug": "abnormal-circulating-thromboxane-concentration",
        "name": "Abnormal circulating thromboxane concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-thromboxane-concentration"
      }
    ],
    "genes": [
      {
        "slug": "pla2g4a",
        "symbol": "PLA2G4A",
        "hgnc": "HGNC:9035",
        "name": "phospholipase A2 group IVA",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pla2g4a"
      }
    ]
  }
}