{
  "url": "https://dantelabs.com/traits/abnormal-circulating-histidine-concentration",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-histidine-concentration",
    "id": "HP:0010904",
    "name": "Abnormal circulating histidine concentration",
    "definition": "Any deviation from the normal concentration of histidine in the blood circulation.",
    "synonyms": [
      "Abnormal histidine level",
      "Abnormality of histidine metabolism"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-aromatic-amino-acid-concentration",
        "name": "Abnormal circulating aromatic amino acid concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-aromatic-amino-acid-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "hyperhistidinemia",
        "name": "High blood histidine level",
        "genes": 1,
        "url": "https://dantelabs.com/traits/hyperhistidinemia"
      }
    ],
    "genes": [
      {
        "slug": "ftcd",
        "symbol": "FTCD",
        "hgnc": "HGNC:3974",
        "name": "formimidoyltransferase cyclodeaminase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ftcd"
      },
      {
        "slug": "uroc1",
        "symbol": "UROC1",
        "hgnc": "HGNC:26444",
        "name": "urocanate hydratase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uroc1"
      },
      {
        "slug": "pnpo",
        "symbol": "PNPO",
        "hgnc": "HGNC:30260",
        "name": "pyridoxamine 5'-phosphate oxidase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pnpo"
      }
    ]
  }
}