{
  "url": "https://dantelabs.com/traits/abnormal-circulating-alpha-fetoprotein-concentration",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-alpha-fetoprotein-concentration",
    "id": "HP:0045056",
    "name": "Abnormal circulating alpha-fetoprotein concentration",
    "definition": "Any deviation from the normal concentration of alpha-fetoprotein in the blood circulation.",
    "synonyms": [
      "Abnormal alpha-fetoprotein level"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-protein-concentration",
        "name": "Blood protein disease",
        "url": "https://dantelabs.com/traits/abnormal-circulating-protein-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "elevated-circulating-alpha-fetoprotein-concentration",
        "name": "Elevated circulating alpha-fetoprotein concentration",
        "genes": 27,
        "url": "https://dantelabs.com/traits/elevated-circulating-alpha-fetoprotein-concentration"
      },
      {
        "slug": "decreased-circulating-alpha-fetoprotein-concentration",
        "name": "Decreased circulating alpha-fetoprotein concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/decreased-circulating-alpha-fetoprotein-concentration"
      }
    ],
    "genes": [
      {
        "slug": "pkhd1",
        "symbol": "PKHD1",
        "hgnc": "HGNC:9016",
        "name": "PKHD1 ciliary IPT domain containing fibrocystin/polyductin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkhd1"
      }
    ]
  }
}