{
  "url": "https://dantelabs.com/traits/abnormal-axial-skeleton-morphology",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-axial-skeleton-morphology",
    "id": "HP:0009121",
    "name": "Abnormal axial skeleton morphology",
    "definition": "An abnormality of the axial skeleton, which comprises the skull, the vertebral column, the ribs and the sternum.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-skeletal-morphology",
        "name": "Abnormally shaped skeletal",
        "url": "https://dantelabs.com/traits/abnormal-skeletal-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-thorax-morphology",
        "name": "Abnormality of the chest",
        "genes": 49,
        "url": "https://dantelabs.com/traits/abnormal-thorax-morphology"
      },
      {
        "slug": "abnormal-skull-morphology",
        "name": "Abnormality of the skull",
        "genes": 43,
        "url": "https://dantelabs.com/traits/abnormal-skull-morphology"
      },
      {
        "slug": "abnormality-of-the-vertebral-column",
        "name": "Abnormality of the vertebral column",
        "genes": 32,
        "url": "https://dantelabs.com/traits/abnormality-of-the-vertebral-column"
      },
      {
        "slug": "disproportionate-short-trunk-short-stature",
        "name": "Disproportionate short-trunked short stature",
        "genes": 24,
        "url": "https://dantelabs.com/traits/disproportionate-short-trunk-short-stature"
      },
      {
        "slug": "aplasia-hypoplasia-affecting-bones-of-the-axial-skeleton",
        "name": "Aplasia/hypoplasia affecting bones of the axial skeleton",
        "genes": 0,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-affecting-bones-of-the-axial-skeleton"
      },
      {
        "slug": "supernumerary-bones-of-the-axial-skeleton",
        "name": "Supernumerary bones of the axial skeleton",
        "genes": 0,
        "url": "https://dantelabs.com/traits/supernumerary-bones-of-the-axial-skeleton"
      }
    ],
    "genes": [
      {
        "slug": "dyrk1a",
        "symbol": "DYRK1A",
        "hgnc": "HGNC:3091",
        "name": "dual specificity tyrosine phosphorylation regulated kinase 1A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dyrk1a"
      }
    ]
  }
}