{
  "url": "https://dantelabs.com/traits/upper-limb-hypertonia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "upper-limb-hypertonia",
    "id": "HP:0200049",
    "name": "Upper limb hypertonia",
    "definition": "Increased muscle tone observed in the arms of the affected person.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-musculature-of-the-upper-limbs",
        "name": "Abnormal upper limb muscles",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculature-of-the-upper-limbs"
      },
      {
        "slug": "limb-hypertonia",
        "name": "Increased muscle tone of arm or leg",
        "url": "https://dantelabs.com/traits/limb-hypertonia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cldn11",
        "symbol": "CLDN11",
        "hgnc": "HGNC:8514",
        "name": "claudin 11",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cldn11"
      },
      {
        "slug": "inpp4a",
        "symbol": "INPP4A",
        "hgnc": "HGNC:6074",
        "name": "inositol polyphosphate-4-phosphatase type I A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inpp4a"
      },
      {
        "slug": "rbsn",
        "symbol": "RBSN",
        "hgnc": "HGNC:20759",
        "name": "rabenosyn, RAB effector",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbsn"
      },
      {
        "slug": "sco2",
        "symbol": "SCO2",
        "hgnc": "HGNC:10604",
        "name": "synthesis of cytochrome C oxidase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sco2"
      },
      {
        "slug": "mtpap",
        "symbol": "MTPAP",
        "hgnc": "HGNC:25532",
        "name": "mitochondrial poly(A) polymerase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mtpap"
      },
      {
        "slug": "vps37a",
        "symbol": "VPS37A",
        "hgnc": "HGNC:24928",
        "name": "VPS37A subunit of ESCRT-I",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vps37a"
      },
      {
        "slug": "sepsecs",
        "symbol": "SEPSECS",
        "hgnc": "HGNC:30605",
        "name": "Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sepsecs"
      },
      {
        "slug": "spg7",
        "symbol": "SPG7",
        "hgnc": "HGNC:11237",
        "name": "SPG7 matrix AAA peptidase subunit, paraplegin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spg7"
      },
      {
        "slug": "tsen15",
        "symbol": "TSEN15",
        "hgnc": "HGNC:16791",
        "name": "tRNA splicing endonuclease subunit 15",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tsen15"
      },
      {
        "slug": "tsen2",
        "symbol": "TSEN2",
        "hgnc": "HGNC:28422",
        "name": "tRNA splicing endonuclease subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tsen2"
      },
      {
        "slug": "tsen34",
        "symbol": "TSEN34",
        "hgnc": "HGNC:15506",
        "name": "tRNA splicing endonuclease subunit 34",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tsen34"
      },
      {
        "slug": "tsen54",
        "symbol": "TSEN54",
        "hgnc": "HGNC:27561",
        "name": "tRNA splicing endonuclease subunit 54",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tsen54"
      },
      {
        "slug": "tuba4a",
        "symbol": "TUBA4A",
        "hgnc": "HGNC:12407",
        "name": "tubulin alpha 4a",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tuba4a"
      }
    ]
  }
}