{
  "url": "https://dantelabs.com/traits/toe-clinodactyly",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "toe-clinodactyly",
    "id": "HP:0001863",
    "name": "Toe curvature",
    "label": "Toe clinodactyly",
    "definition": "Bending or curvature of a toe in the tibial direction (i.e., towards the big toe).",
    "synonyms": [
      "Clinodactyly of feet"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "clinodactyly",
        "name": "Curvature of digit",
        "url": "https://dantelabs.com/traits/clinodactyly"
      },
      {
        "slug": "deviation-of-toes",
        "name": "Deviation of toes",
        "url": "https://dantelabs.com/traits/deviation-of-toes"
      }
    ],
    "narrower": [
      {
        "slug": "clinodactyly-of-the-5th-toe",
        "name": "Clinodactyly of the 5th toe",
        "genes": 17,
        "url": "https://dantelabs.com/traits/clinodactyly-of-the-5th-toe"
      },
      {
        "slug": "clinodactyly-of-the-4th-toe",
        "name": "Curvature of 4th toe",
        "genes": 6,
        "url": "https://dantelabs.com/traits/clinodactyly-of-the-4th-toe"
      },
      {
        "slug": "clinodactyly-of-the-2nd-toe",
        "name": "Curvature of 2nd toe",
        "genes": 2,
        "url": "https://dantelabs.com/traits/clinodactyly-of-the-2nd-toe"
      },
      {
        "slug": "clinodactyly-of-the-3rd-toe",
        "name": "Curvature of 3rd toe",
        "genes": 2,
        "url": "https://dantelabs.com/traits/clinodactyly-of-the-3rd-toe"
      }
    ],
    "genes": [
      {
        "slug": "taf4",
        "symbol": "TAF4",
        "hgnc": "HGNC:11537",
        "name": "TATA-box binding protein associated factor 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taf4"
      },
      {
        "slug": "dact1",
        "symbol": "DACT1",
        "hgnc": "HGNC:17748",
        "name": "dishevelled binding antagonist of beta catenin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dact1"
      },
      {
        "slug": "ezh2",
        "symbol": "EZH2",
        "hgnc": "HGNC:3527",
        "name": "enhancer of zeste 2 polycomb repressive complex 2 subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ezh2"
      },
      {
        "slug": "fli1",
        "symbol": "FLI1",
        "hgnc": "HGNC:3749",
        "name": "Fli-1 proto-oncogene, ETS transcription factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fli1"
      },
      {
        "slug": "sall1",
        "symbol": "SALL1",
        "hgnc": "HGNC:10524",
        "name": "spalt like transcription factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sall1"
      },
      {
        "slug": "tshz3",
        "symbol": "TSHZ3",
        "hgnc": "HGNC:30700",
        "name": "teashirt zinc finger homeobox 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tshz3"
      },
      {
        "slug": "atp2b1",
        "symbol": "ATP2B1",
        "hgnc": "HGNC:814",
        "name": "ATPase plasma membrane Ca2+ transporting 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp2b1"
      },
      {
        "slug": "bcl11a",
        "symbol": "BCL11A",
        "hgnc": "HGNC:13221",
        "name": "BCL11 transcription factor A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcl11a"
      },
      {
        "slug": "rel",
        "symbol": "REL",
        "hgnc": "HGNC:9954",
        "name": "REL proto-oncogene, NF-kB subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rel"
      },
      {
        "slug": "rfx7",
        "symbol": "RFX7",
        "hgnc": "HGNC:25777",
        "name": "regulatory factor X7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfx7"
      },
      {
        "slug": "rspry1",
        "symbol": "RSPRY1",
        "hgnc": "HGNC:29420",
        "name": "ring finger and SPRY domain containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rspry1"
      },
      {
        "slug": "satb2",
        "symbol": "SATB2",
        "hgnc": "HGNC:21637",
        "name": "SATB homeobox 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/satb2"
      },
      {
        "slug": "xpo1",
        "symbol": "XPO1",
        "hgnc": "HGNC:12825",
        "name": "exportin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xpo1"
      },
      {
        "slug": "xylt1",
        "symbol": "XYLT1",
        "hgnc": "HGNC:15516",
        "name": "xylosyltransferase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xylt1"
      },
      {
        "slug": "flna",
        "symbol": "FLNA",
        "hgnc": "HGNC:3754",
        "name": "filamin A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flna"
      }
    ]
  }
}