{
  "url": "https://dantelabs.com/traits/sideroblastic-anemia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "sideroblastic-anemia",
    "id": "HP:0001924",
    "name": "Sideroblastic anemia",
    "definition": "Sideroblastic anemia results from a defect in the incorporation of iron into the heme molecule. A sideroblast is an erythroblast that has stainable deposits of iron in cytoplasm (this can be demonstrated by Prussian blue staining).",
    "synonyms": [
      "Hypersideremic anaemia",
      "Hypersideremic anemia",
      "Sideroblastic anaemia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "anemia-of-inadequate-production",
        "name": "Anemia of inadequate production",
        "url": "https://dantelabs.com/traits/anemia-of-inadequate-production"
      }
    ],
    "narrower": [
      {
        "slug": "pyridoxine-responsive-sideroblastic-anemia",
        "name": "Pyridoxine-responsive sideroblastic anemia",
        "genes": 24,
        "url": "https://dantelabs.com/traits/pyridoxine-responsive-sideroblastic-anemia"
      }
    ],
    "genes": [
      {
        "slug": "abcb7",
        "symbol": "ABCB7",
        "hgnc": "HGNC:48",
        "name": "ATP binding cassette subfamily B member 7",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/abcb7"
      },
      {
        "slug": "alas2",
        "symbol": "ALAS2",
        "hgnc": "HGNC:397",
        "name": "5'-aminolevulinate synthase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alas2"
      },
      {
        "slug": "pus1",
        "symbol": "PUS1",
        "hgnc": "HGNC:15508",
        "name": "pseudouridine synthase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pus1"
      },
      {
        "slug": "trnt1",
        "symbol": "TRNT1",
        "hgnc": "HGNC:17341",
        "name": "tRNA nucleotidyl transferase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trnt1"
      },
      {
        "slug": "yars2",
        "symbol": "YARS2",
        "hgnc": "HGNC:24249",
        "name": "tyrosyl-tRNA synthetase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yars2"
      },
      {
        "slug": "steap3",
        "symbol": "STEAP3",
        "hgnc": "HGNC:24592",
        "name": "STEAP3 metalloreductase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/steap3"
      },
      {
        "slug": "hspa9",
        "symbol": "HSPA9",
        "hgnc": "HGNC:5244",
        "name": "heat shock protein family A (Hsp70) member 9",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hspa9"
      },
      {
        "slug": "iscu",
        "symbol": "ISCU",
        "hgnc": "HGNC:29882",
        "name": "iron-sulfur cluster assembly enzyme",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/iscu"
      },
      {
        "slug": "lars2",
        "symbol": "LARS2",
        "hgnc": "HGNC:17095",
        "name": "leucyl-tRNA synthetase 2, mitochondrial",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lars2"
      },
      {
        "slug": "slc19a2",
        "symbol": "SLC19A2",
        "hgnc": "HGNC:10938",
        "name": "solute carrier family 19 member 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc19a2"
      },
      {
        "slug": "slc25a38",
        "symbol": "SLC25A38",
        "hgnc": "HGNC:26054",
        "name": "solute carrier family 25 member 38",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a38"
      },
      {
        "slug": "wfs1",
        "symbol": "WFS1",
        "hgnc": "HGNC:12762",
        "name": "wolframin ER transmembrane glycoprotein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wfs1"
      }
    ]
  }
}