{
  "url": "https://dantelabs.com/traits/severe-infection",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "severe-infection",
    "id": "HP:0032169",
    "name": "Severe infection",
    "definition": "A type of infection that is regarded as a sign of a pathological susceptibility to infection because of unusual severity or intensity of the infection.",
    "synonyms": [
      "Unusual course of infection"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "unusual-infection",
        "name": "Unusual infection",
        "url": "https://dantelabs.com/traits/unusual-infection"
      }
    ],
    "narrower": [
      {
        "slug": "severe-viral-infection",
        "name": "Severe viral infection",
        "genes": 12,
        "url": "https://dantelabs.com/traits/severe-viral-infection"
      },
      {
        "slug": "persistent-human-papillomavirus-infection",
        "name": "Persistent human papillomavirus infection",
        "genes": 3,
        "url": "https://dantelabs.com/traits/persistent-human-papillomavirus-infection"
      },
      {
        "slug": "persistent-viremia",
        "name": "Persistent viremia",
        "genes": 1,
        "url": "https://dantelabs.com/traits/persistent-viremia"
      },
      {
        "slug": "viral-encephalitis",
        "name": "Viral encephalitis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/viral-encephalitis"
      }
    ],
    "genes": [
      {
        "slug": "copz1",
        "symbol": "COPZ1",
        "hgnc": "HGNC:2243",
        "name": "coat protein complex I subunit zeta 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/copz1"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "prps1",
        "symbol": "PRPS1",
        "hgnc": "HGNC:9462",
        "name": "phosphoribosyl pyrophosphate synthetase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prps1"
      },
      {
        "slug": "cxcr2",
        "symbol": "CXCR2",
        "hgnc": "HGNC:6027",
        "name": "C-X-C motif chemokine receptor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cxcr2"
      },
      {
        "slug": "fcgr3b",
        "symbol": "FCGR3B",
        "hgnc": "HGNC:3620",
        "name": "Fc gamma receptor IIIb",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fcgr3b"
      },
      {
        "slug": "foxn1",
        "symbol": "FOXN1",
        "hgnc": "HGNC:12765",
        "name": "forkhead box N1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxn1"
      },
      {
        "slug": "foxp3",
        "symbol": "FOXP3",
        "hgnc": "HGNC:6106",
        "name": "forkhead box P3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxp3"
      },
      {
        "slug": "ighg2",
        "symbol": "IGHG2",
        "hgnc": "HGNC:5526",
        "name": "immunoglobulin heavy constant gamma 2 (G2m marker)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ighg2"
      },
      {
        "slug": "igkc",
        "symbol": "IGKC",
        "hgnc": "HGNC:5716",
        "name": "immunoglobulin kappa constant",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igkc"
      },
      {
        "slug": "bcl11a",
        "symbol": "BCL11A",
        "hgnc": "HGNC:13221",
        "name": "BCL11 transcription factor A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcl11a"
      },
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hbb"
      },
      {
        "slug": "hbg1",
        "symbol": "HBG1",
        "hgnc": "HGNC:4831",
        "name": "hemoglobin subunit gamma 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hbg1"
      },
      {
        "slug": "hbg2",
        "symbol": "HBG2",
        "hgnc": "HGNC:4832",
        "name": "hemoglobin subunit gamma 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hbg2"
      },
      {
        "slug": "klf1",
        "symbol": "KLF1",
        "hgnc": "HGNC:6345",
        "name": "KLF transcription factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klf1"
      },
      {
        "slug": "elane",
        "symbol": "ELANE",
        "hgnc": "HGNC:3309",
        "name": "elastase, neutrophil expressed",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elane"
      }
    ]
  }
}