{
  "url": "https://dantelabs.com/traits/semantic-dementia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "semantic-dementia",
    "id": "HP:0030219",
    "name": "Trouble remembering words",
    "label": "Semantic dementia",
    "definition": "A progressive loss of the ability to remember the meaning of words, faces and objects.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "frontotemporal-dementia",
        "name": "Frontotemporal dementia",
        "url": "https://dantelabs.com/traits/frontotemporal-dementia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "app",
        "symbol": "APP",
        "hgnc": "HGNC:620",
        "name": "amyloid beta precursor protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/app"
      },
      {
        "slug": "psen1",
        "symbol": "PSEN1",
        "hgnc": "HGNC:9508",
        "name": "presenilin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psen1"
      },
      {
        "slug": "psen2",
        "symbol": "PSEN2",
        "hgnc": "HGNC:9509",
        "name": "presenilin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psen2"
      },
      {
        "slug": "sorl1",
        "symbol": "SORL1",
        "hgnc": "HGNC:11185",
        "name": "sortilin related receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sorl1"
      },
      {
        "slug": "tomm40",
        "symbol": "TOMM40",
        "hgnc": "HGNC:18001",
        "name": "translocase of outer mitochondrial membrane 40",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tomm40"
      },
      {
        "slug": "trem2",
        "symbol": "TREM2",
        "hgnc": "HGNC:17761",
        "name": "triggering receptor expressed on myeloid cells 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trem2"
      }
    ]
  }
}