{
  "url": "https://dantelabs.com/traits/osteopetrosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "osteopetrosis",
    "id": "HP:0011002",
    "name": "Harder, denser, fracture-prone bones",
    "label": "Osteopetrosis",
    "definition": "Abnormally increased formation of dense trabecular bone tissue. Despite the increased density of bone tissue, osteopetrotic bones tend to be more fracture-prone than normal.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "increased-bone-mineral-density",
        "name": "Increased bone mineral density",
        "url": "https://dantelabs.com/traits/increased-bone-mineral-density"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "ca2",
        "symbol": "CA2",
        "hgnc": "HGNC:1373",
        "name": "carbonic anhydrase 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ca2"
      },
      {
        "slug": "clcn7",
        "symbol": "CLCN7",
        "hgnc": "HGNC:2025",
        "name": "Cl-/H+ antiporter 7",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/clcn7"
      },
      {
        "slug": "ikbkg",
        "symbol": "IKBKG",
        "hgnc": "HGNC:5961",
        "name": "inhibitor of nuclear factor kappa B kinase regulatory subunit gamma",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ikbkg"
      },
      {
        "slug": "lrp6",
        "symbol": "LRP6",
        "hgnc": "HGNC:6698",
        "name": "LDL receptor related protein 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp6"
      },
      {
        "slug": "ostm1",
        "symbol": "OSTM1",
        "hgnc": "HGNC:21652",
        "name": "osteoclastogenesis associated transmembrane protein 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ostm1"
      },
      {
        "slug": "plekhm1",
        "symbol": "PLEKHM1",
        "hgnc": "HGNC:29017",
        "name": "pleckstrin homology and RUN domain containing M1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plekhm1"
      },
      {
        "slug": "slc4a2",
        "symbol": "SLC4A2",
        "hgnc": "HGNC:11028",
        "name": "solute carrier family 4 member 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc4a2"
      },
      {
        "slug": "snx10",
        "symbol": "SNX10",
        "hgnc": "HGNC:14974",
        "name": "sorting nexin 10",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/snx10"
      },
      {
        "slug": "tcirg1",
        "symbol": "TCIRG1",
        "hgnc": "HGNC:11647",
        "name": "T cell immune regulator 1, ATPase H+ transporting V0 subunit a3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tcirg1"
      },
      {
        "slug": "tnfrsf11a",
        "symbol": "TNFRSF11A",
        "hgnc": "HGNC:11908",
        "name": "TNF receptor superfamily member 11a",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf11a"
      },
      {
        "slug": "amer1",
        "symbol": "AMER1",
        "hgnc": "HGNC:26837",
        "name": "APC membrane recruitment protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/amer1"
      },
      {
        "slug": "ankh",
        "symbol": "ANKH",
        "hgnc": "HGNC:15492",
        "name": "ANKH inorganic pyrophosphate transport regulator",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ankh"
      },
      {
        "slug": "ctnnb1",
        "symbol": "CTNNB1",
        "hgnc": "HGNC:2514",
        "name": "catenin beta 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctnnb1"
      },
      {
        "slug": "gja1",
        "symbol": "GJA1",
        "hgnc": "HGNC:4274",
        "name": "gap junction protein alpha 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja1"
      },
      {
        "slug": "ptdss1",
        "symbol": "PTDSS1",
        "hgnc": "HGNC:9587",
        "name": "phosphatidylserine synthase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptdss1"
      },
      {
        "slug": "tnfsf11",
        "symbol": "TNFSF11",
        "hgnc": "HGNC:11926",
        "name": "TNF superfamily member 11",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tnfsf11"
      },
      {
        "slug": "mitf",
        "symbol": "MITF",
        "hgnc": "HGNC:7105",
        "name": "melanocyte inducing transcription factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mitf"
      },
      {
        "slug": "csf1r",
        "symbol": "CSF1R",
        "hgnc": "HGNC:2433",
        "name": "colony stimulating factor 1 receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csf1r"
      },
      {
        "slug": "dhcr24",
        "symbol": "DHCR24",
        "hgnc": "HGNC:2859",
        "name": "24-dehydrocholesterol reductase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhcr24"
      },
      {
        "slug": "fbxo22",
        "symbol": "FBXO22",
        "hgnc": "HGNC:13593",
        "name": "F-box protein 22",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo22"
      },
      {
        "slug": "fermt3",
        "symbol": "FERMT3",
        "hgnc": "HGNC:23151",
        "name": "FERM domain containing kindlin 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fermt3"
      },
      {
        "slug": "kars1",
        "symbol": "KARS1",
        "hgnc": "HGNC:6215",
        "name": "lysyl-tRNA synthetase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kars1"
      },
      {
        "slug": "lrp5",
        "symbol": "LRP5",
        "hgnc": "HGNC:6697",
        "name": "LDL receptor related protein 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp5"
      }
    ]
  }
}