{
  "url": "https://dantelabs.com/traits/myelofibrosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "myelofibrosis",
    "id": "HP:0011974",
    "name": "Myelofibrosis",
    "definition": "Replacement of bone marrow by fibrous tissue.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-multiple-cell-lineages-in-the-bone-marrow",
        "name": "Abnormality of multiple cell lineages in the bone marrow",
        "url": "https://dantelabs.com/traits/abnormality-of-multiple-cell-lineages-in-the-bone-marrow"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "calr",
        "symbol": "CALR",
        "hgnc": "HGNC:1455",
        "name": "calreticulin",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/calr"
      },
      {
        "slug": "gfi1b",
        "symbol": "GFI1B",
        "hgnc": "HGNC:4238",
        "name": "growth factor independent 1B transcriptional repressor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gfi1b"
      },
      {
        "slug": "jak2",
        "symbol": "JAK2",
        "hgnc": "HGNC:6192",
        "name": "Janus kinase 2",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/jak2"
      },
      {
        "slug": "mpig6b",
        "symbol": "MPIG6B",
        "hgnc": "HGNC:13937",
        "name": "megakaryocyte and platelet inhibitory receptor G6b",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpig6b"
      },
      {
        "slug": "mpl",
        "symbol": "MPL",
        "hgnc": "HGNC:7217",
        "name": "MPL proto-oncogene, thrombopoietin receptor",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mpl"
      },
      {
        "slug": "sh2b3",
        "symbol": "SH2B3",
        "hgnc": "HGNC:29605",
        "name": "SH2B adaptor protein 3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sh2b3"
      },
      {
        "slug": "tbxas1",
        "symbol": "TBXAS1",
        "hgnc": "HGNC:11609",
        "name": "thromboxane A synthase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbxas1"
      },
      {
        "slug": "rbsn",
        "symbol": "RBSN",
        "hgnc": "HGNC:20759",
        "name": "rabenosyn, RAB effector",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbsn"
      },
      {
        "slug": "hpgd",
        "symbol": "HPGD",
        "hgnc": "HGNC:5154",
        "name": "15-hydroxyprostaglandin dehydrogenase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hpgd"
      },
      {
        "slug": "shoc2",
        "symbol": "SHOC2",
        "hgnc": "HGNC:15454",
        "name": "SHOC2 leucine rich repeat scaffold protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/shoc2"
      },
      {
        "slug": "slco2a1",
        "symbol": "SLCO2A1",
        "hgnc": "HGNC:10955",
        "name": "solute carrier organic anion transporter family member 2A1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slco2a1"
      },
      {
        "slug": "tet2",
        "symbol": "TET2",
        "hgnc": "HGNC:25941",
        "name": "tet methylcytosine dioxygenase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tet2"
      },
      {
        "slug": "tlr8",
        "symbol": "TLR8",
        "hgnc": "HGNC:15632",
        "name": "toll like receptor 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tlr8"
      },
      {
        "slug": "tp53",
        "symbol": "TP53",
        "hgnc": "HGNC:11998",
        "name": "tumor protein p53",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp53"
      },
      {
        "slug": "nbeal2",
        "symbol": "NBEAL2",
        "hgnc": "HGNC:31928",
        "name": "neurobeachin like 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nbeal2"
      },
      {
        "slug": "src",
        "symbol": "SRC",
        "hgnc": "HGNC:11283",
        "name": "SRC proto-oncogene, non-receptor tyrosine kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/src"
      }
    ]
  }
}