{
  "url": "https://dantelabs.com/traits/monochromacy",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "monochromacy",
    "id": "HP:0007803",
    "name": "Total colorblindness",
    "label": "Monochromacy",
    "definition": "Complete color blindness, a complete inability to distinguish colors. Affected persons cannot perceive colors, but only shades of gray.",
    "synonyms": [
      "Complete achromatopsia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "color-vision-defect",
        "name": "Abnormal color vision",
        "url": "https://dantelabs.com/traits/color-vision-defect"
      }
    ],
    "narrower": [
      {
        "slug": "achromatopsia",
        "name": "Achromatopsia",
        "genes": 5,
        "url": "https://dantelabs.com/traits/achromatopsia"
      },
      {
        "slug": "cone-monochromacy",
        "name": "Cone monochromacy",
        "genes": 0,
        "url": "https://dantelabs.com/traits/cone-monochromacy"
      }
    ],
    "genes": [
      {
        "slug": "atf6",
        "symbol": "ATF6",
        "hgnc": "HGNC:791",
        "name": "activating transcription factor 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atf6"
      },
      {
        "slug": "cnga3",
        "symbol": "CNGA3",
        "hgnc": "HGNC:2150",
        "name": "cyclic nucleotide gated channel subunit alpha 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cnga3"
      },
      {
        "slug": "cngb3",
        "symbol": "CNGB3",
        "hgnc": "HGNC:2153",
        "name": "cyclic nucleotide gated channel subunit beta 3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cngb3"
      },
      {
        "slug": "gnat2",
        "symbol": "GNAT2",
        "hgnc": "HGNC:4394",
        "name": "G protein subunit alpha transducin 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnat2"
      },
      {
        "slug": "pde6c",
        "symbol": "PDE6C",
        "hgnc": "HGNC:8787",
        "name": "phosphodiesterase 6C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde6c"
      },
      {
        "slug": "pde6h",
        "symbol": "PDE6H",
        "hgnc": "HGNC:8790",
        "name": "phosphodiesterase 6H",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde6h"
      },
      {
        "slug": "rpgr",
        "symbol": "RPGR",
        "hgnc": "HGNC:10295",
        "name": "retinitis pigmentosa GTPase regulator",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpgr"
      },
      {
        "slug": "cnnm4",
        "symbol": "CNNM4",
        "hgnc": "HGNC:105",
        "name": "cyclin and CBS domain divalent metal cation transport mediator 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cnnm4"
      }
    ]
  }
}