{
  "url": "https://dantelabs.com/traits/mediastinal-mass",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "mediastinal-mass",
    "id": "HP:0033823",
    "name": "Mediastinal mass",
    "definition": "A mass in the mediastinum seen on chest imaging is defined as an opacity greater than 3 cm in diameter (without regard to contour, border, or density characteristics).",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-respiratory-system",
        "name": "Abnormality of the respiratory system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-respiratory-system"
      }
    ],
    "broader": [
      {
        "slug": "mass-on-thoracic-imaging",
        "name": "Mass on thoracic imaging",
        "url": "https://dantelabs.com/traits/mass-on-thoracic-imaging"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "bcl2",
        "symbol": "BCL2",
        "hgnc": "HGNC:990",
        "name": "BCL2 apoptosis regulator",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcl2"
      },
      {
        "slug": "bcl6",
        "symbol": "BCL6",
        "hgnc": "HGNC:1001",
        "name": "BCL6 transcription repressor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcl6"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "igh",
        "symbol": "IGH",
        "hgnc": "HGNC:5477",
        "name": "immunoglobulin heavy locus",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igh"
      },
      {
        "slug": "kif1b",
        "symbol": "KIF1B",
        "hgnc": "HGNC:16636",
        "name": "kinesin family member 1B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif1b"
      }
    ]
  }
}