{
  "url": "https://dantelabs.com/traits/low-cholesterol-esterification-rate",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "low-cholesterol-esterification-rate",
    "id": "HP:0003349",
    "name": "Low cholesterol esterification rate",
    "definition": "A reduction in the rate of cholesterol esterification.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-enzyme-concentration-or-activity",
        "name": "Abnormal circulating enzyme concentration or activity",
        "url": "https://dantelabs.com/traits/abnormal-circulating-enzyme-concentration-or-activity"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "npc1",
        "symbol": "NPC1",
        "hgnc": "HGNC:7897",
        "name": "NPC intracellular cholesterol transporter 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npc1"
      },
      {
        "slug": "npc2",
        "symbol": "NPC2",
        "hgnc": "HGNC:14537",
        "name": "NPC intracellular cholesterol transporter 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npc2"
      }
    ]
  }
}