{
  "url": "https://dantelabs.com/traits/low-back-pain",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "low-back-pain",
    "id": "HP:0003419",
    "name": "Lumbago",
    "label": "Low back pain",
    "definition": "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the lower back.",
    "synonyms": [
      "Lower back pain"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      },
      {
        "slug": "constitutional-symptom",
        "name": "Constitutional symptom",
        "url": "https://dantelabs.com/traits/constitutional-symptom"
      }
    ],
    "broader": [
      {
        "slug": "back-pain",
        "name": "Back pain",
        "url": "https://dantelabs.com/traits/back-pain"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "aebp1",
        "symbol": "AEBP1",
        "hgnc": "HGNC:303",
        "name": "AE binding protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aebp1"
      },
      {
        "slug": "ptcra",
        "symbol": "PTCRA",
        "hgnc": "HGNC:21290",
        "name": "pre T cell antigen receptor alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptcra"
      },
      {
        "slug": "wrn",
        "symbol": "WRN",
        "hgnc": "HGNC:12791",
        "name": "WRN RecQ like helicase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wrn"
      },
      {
        "slug": "anxa11",
        "symbol": "ANXA11",
        "hgnc": "HGNC:535",
        "name": "annexin A11",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/anxa11"
      },
      {
        "slug": "hgd",
        "symbol": "HGD",
        "hgnc": "HGNC:4892",
        "name": "homogentisate 1,2-dioxygenase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hgd"
      },
      {
        "slug": "hla-b",
        "symbol": "HLA-B",
        "hgnc": "HGNC:4932",
        "name": "major histocompatibility complex, class I, B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-b"
      },
      {
        "slug": "mnx1",
        "symbol": "MNX1",
        "hgnc": "HGNC:4979",
        "name": "motor neuron and pancreas homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mnx1"
      },
      {
        "slug": "ngf",
        "symbol": "NGF",
        "hgnc": "HGNC:7808",
        "name": "nerve growth factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ngf"
      },
      {
        "slug": "washc5",
        "symbol": "WASHC5",
        "hgnc": "HGNC:28984",
        "name": "WASH complex subunit 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/washc5"
      },
      {
        "slug": "aldh18a1",
        "symbol": "ALDH18A1",
        "hgnc": "HGNC:9722",
        "name": "aldehyde dehydrogenase 18 family member A1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh18a1"
      },
      {
        "slug": "bnc2",
        "symbol": "BNC2",
        "hgnc": "HGNC:30988",
        "name": "basonuclin zinc finger protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bnc2"
      },
      {
        "slug": "mefv",
        "symbol": "MEFV",
        "hgnc": "HGNC:6998",
        "name": "MEFV innate immunity regulator, pyrin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mefv"
      },
      {
        "slug": "nab2",
        "symbol": "NAB2",
        "hgnc": "HGNC:7627",
        "name": "NGFI-A binding protein 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nab2"
      },
      {
        "slug": "stat6",
        "symbol": "STAT6",
        "hgnc": "HGNC:11368",
        "name": "signal transducer and activator of transcription 6",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat6"
      },
      {
        "slug": "htra1",
        "symbol": "HTRA1",
        "hgnc": "HGNC:9476",
        "name": "HtrA serine peptidase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/htra1"
      },
      {
        "slug": "spast",
        "symbol": "SPAST",
        "hgnc": "HGNC:11233",
        "name": "spastin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spast"
      },
      {
        "slug": "tbx6",
        "symbol": "TBX6",
        "hgnc": "HGNC:11605",
        "name": "T-box transcription factor 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx6"
      }
    ]
  }
}