{
  "url": "https://dantelabs.com/traits/limb-tremor",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "limb-tremor",
    "id": "HP:0200085",
    "name": "Limb tremor",
    "synonyms": [
      "Involuntary shaking of limb",
      "Tremor of limbs"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "tremor-by-anatomical-site",
        "name": "Tremor of a body part",
        "url": "https://dantelabs.com/traits/tremor-by-anatomical-site"
      }
    ],
    "narrower": [
      {
        "slug": "upper-limb-postural-tremor",
        "name": "Upper limb postural tremor",
        "genes": 12,
        "url": "https://dantelabs.com/traits/upper-limb-postural-tremor"
      }
    ],
    "genes": [
      {
        "slug": "cln5",
        "symbol": "CLN5",
        "hgnc": "HGNC:2076",
        "name": "CLN5 lysosomal BMP synthase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cln5"
      },
      {
        "slug": "gria3",
        "symbol": "GRIA3",
        "hgnc": "HGNC:4573",
        "name": "glutamate ionotropic receptor AMPA type subunit 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gria3"
      },
      {
        "slug": "unc13a",
        "symbol": "UNC13A",
        "hgnc": "HGNC:23150",
        "name": "unc-13 homolog A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc13a"
      },
      {
        "slug": "ano3",
        "symbol": "ANO3",
        "hgnc": "HGNC:14004",
        "name": "anoctamin 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ano3"
      },
      {
        "slug": "ciz1",
        "symbol": "CIZ1",
        "hgnc": "HGNC:16744",
        "name": "CDKN1A interacting zinc finger protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ciz1"
      },
      {
        "slug": "ddc",
        "symbol": "DDC",
        "hgnc": "HGNC:2719",
        "name": "dopa decarboxylase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddc"
      },
      {
        "slug": "pgap1",
        "symbol": "PGAP1",
        "hgnc": "HGNC:25712",
        "name": "post-GPI attachment to proteins inositol deacylase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pgap1"
      },
      {
        "slug": "rab3a",
        "symbol": "RAB3A",
        "hgnc": "HGNC:9777",
        "name": "RAB3A, member RAS oncogene family",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab3a"
      },
      {
        "slug": "cdc42bpb",
        "symbol": "CDC42BPB",
        "hgnc": "HGNC:1738",
        "name": "CDC42 binding protein kinase beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdc42bpb"
      },
      {
        "slug": "pex16",
        "symbol": "PEX16",
        "hgnc": "HGNC:8857",
        "name": "peroxisomal biogenesis factor 16",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex16"
      },
      {
        "slug": "itpa",
        "symbol": "ITPA",
        "hgnc": "HGNC:6176",
        "name": "inosine triphosphatase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itpa"
      },
      {
        "slug": "slc12a6",
        "symbol": "SLC12A6",
        "hgnc": "HGNC:10914",
        "name": "solute carrier family 12 member 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc12a6"
      },
      {
        "slug": "ube3a",
        "symbol": "UBE3A",
        "hgnc": "HGNC:12496",
        "name": "ubiquitin protein ligase E3A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ube3a"
      }
    ]
  }
}