{
  "url": "https://dantelabs.com/traits/lactic-acidosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "lactic-acidosis",
    "id": "HP:0003128",
    "name": "Increased lactate in body",
    "label": "Lactic acidosis",
    "definition": "An abnormal buildup of lactic acid in the body, leading to acidification of the blood and other bodily fluids.",
    "synonyms": [
      "Hyperlacticacidemia",
      "Lactic acidemia",
      "Lacticacidemia",
      "Lacticacidosis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "acidosis",
        "name": "Acidosis",
        "url": "https://dantelabs.com/traits/acidosis"
      }
    ],
    "narrower": [
      {
        "slug": "severe-lactic-acidosis",
        "name": "Severe lactic acidosis",
        "genes": 14,
        "url": "https://dantelabs.com/traits/severe-lactic-acidosis"
      },
      {
        "slug": "congenital-lactic-acidosis",
        "name": "Congenital lactic acidosis",
        "genes": 4,
        "url": "https://dantelabs.com/traits/congenital-lactic-acidosis"
      },
      {
        "slug": "intermittent-lactic-acidemia",
        "name": "Intermittent lactic acidemia",
        "genes": 3,
        "url": "https://dantelabs.com/traits/intermittent-lactic-acidemia"
      },
      {
        "slug": "stress-infection-induced-lactic-acidosis",
        "name": "Stress/infection-induced lactic acidosis",
        "genes": 3,
        "url": "https://dantelabs.com/traits/stress-infection-induced-lactic-acidosis"
      },
      {
        "slug": "chronic-lactic-acidosis",
        "name": "Chronic lactic acidosis",
        "genes": 2,
        "url": "https://dantelabs.com/traits/chronic-lactic-acidosis"
      },
      {
        "slug": "exercise-induced-lactic-acidemia",
        "name": "Exercise-induced lactic acidemia",
        "genes": 1,
        "url": "https://dantelabs.com/traits/exercise-induced-lactic-acidemia"
      },
      {
        "slug": "persistent-lactic-acidosis",
        "name": "Persistent lactic acidosis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/persistent-lactic-acidosis"
      }
    ],
    "genes": [
      {
        "slug": "acad9",
        "symbol": "ACAD9",
        "hgnc": "HGNC:21497",
        "name": "acyl-CoA dehydrogenase family member 9",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/acad9"
      },
      {
        "slug": "agk",
        "symbol": "AGK",
        "hgnc": "HGNC:21869",
        "name": "acylglycerol kinase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/agk"
      },
      {
        "slug": "bcs1l",
        "symbol": "BCS1L",
        "hgnc": "HGNC:1020",
        "name": "BCS1 ubiquinol-cytochrome c reductase complex chaperone",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/bcs1l"
      },
      {
        "slug": "bola3",
        "symbol": "BOLA3",
        "hgnc": "HGNC:24415",
        "name": "bolA family member 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bola3"
      },
      {
        "slug": "coa6",
        "symbol": "COA6",
        "hgnc": "HGNC:18025",
        "name": "cytochrome c oxidase assembly factor 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coa6"
      },
      {
        "slug": "coq9",
        "symbol": "COQ9",
        "hgnc": "HGNC:25302",
        "name": "coenzyme Q9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coq9"
      },
      {
        "slug": "cox10",
        "symbol": "COX10",
        "hgnc": "HGNC:2260",
        "name": "cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cox10"
      },
      {
        "slug": "cox15",
        "symbol": "COX15",
        "hgnc": "HGNC:2263",
        "name": "cytochrome c oxidase assembly factor COX15",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cox15"
      },
      {
        "slug": "cox6b1",
        "symbol": "COX6B1",
        "hgnc": "HGNC:2280",
        "name": "cytochrome c oxidase subunit 6B1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cox6b1"
      },
      {
        "slug": "cox8a",
        "symbol": "COX8A",
        "hgnc": "HGNC:2294",
        "name": "cytochrome c oxidase subunit 8A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox8a"
      },
      {
        "slug": "coxfa4",
        "symbol": "COXFA4",
        "hgnc": "HGNC:7687",
        "name": "cytochrome c oxidase associated subunit FA4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coxfa4"
      },
      {
        "slug": "cyc1",
        "symbol": "CYC1",
        "hgnc": "HGNC:2579",
        "name": "cytochrome c1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyc1"
      },
      {
        "slug": "dguok",
        "symbol": "DGUOK",
        "hgnc": "HGNC:2858",
        "name": "deoxyguanosine kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dguok"
      },
      {
        "slug": "dnm1l",
        "symbol": "DNM1L",
        "hgnc": "HGNC:2973",
        "name": "dynamin 1L",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnm1l"
      },
      {
        "slug": "ears2",
        "symbol": "EARS2",
        "hgnc": "HGNC:29419",
        "name": "glutamyl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ears2"
      },
      {
        "slug": "eefsec",
        "symbol": "EEFSEC",
        "hgnc": "HGNC:24614",
        "name": "eukaryotic elongation factor, selenocysteine-tRNA specific",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eefsec"
      },
      {
        "slug": "ethe1",
        "symbol": "ETHE1",
        "hgnc": "HGNC:23287",
        "name": "ETHE1 persulfide dioxygenase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ethe1"
      },
      {
        "slug": "fars2",
        "symbol": "FARS2",
        "hgnc": "HGNC:21062",
        "name": "phenylalanyl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fars2"
      },
      {
        "slug": "fastkd2",
        "symbol": "FASTKD2",
        "hgnc": "HGNC:29160",
        "name": "FASTK mitochondrial RNA regulator 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fastkd2"
      },
      {
        "slug": "fbxl4",
        "symbol": "FBXL4",
        "hgnc": "HGNC:13601",
        "name": "F-box and leucine rich repeat protein 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxl4"
      },
      {
        "slug": "fdx2",
        "symbol": "FDX2",
        "hgnc": "HGNC:30546",
        "name": "ferredoxin 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fdx2"
      },
      {
        "slug": "foxred1",
        "symbol": "FOXRED1",
        "hgnc": "HGNC:26927",
        "name": "FAD dependent oxidoreductase domain containing 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/foxred1"
      },
      {
        "slug": "g6pc1",
        "symbol": "G6PC1",
        "hgnc": "HGNC:4056",
        "name": "glucose-6-phosphatase catalytic subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/g6pc1"
      },
      {
        "slug": "gatb",
        "symbol": "GATB",
        "hgnc": "HGNC:8849",
        "name": "glutamyl-tRNA amidotransferase subunit B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gatb"
      },
      {
        "slug": "gatc",
        "symbol": "GATC",
        "hgnc": "HGNC:25068",
        "name": "glutamyl-tRNA amidotransferase subunit C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gatc"
      },
      {
        "slug": "gtpbp3",
        "symbol": "GTPBP3",
        "hgnc": "HGNC:14880",
        "name": "GTP binding protein 3, mitochondrial",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gtpbp3"
      },
      {
        "slug": "hlcs",
        "symbol": "HLCS",
        "hgnc": "HGNC:4976",
        "name": "holocarboxylase synthetase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hlcs"
      },
      {
        "slug": "iba57",
        "symbol": "IBA57",
        "hgnc": "HGNC:27302",
        "name": "iron-sulfur cluster assembly factor IBA57",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/iba57"
      },
      {
        "slug": "lars2",
        "symbol": "LARS2",
        "hgnc": "HGNC:17095",
        "name": "leucyl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lars2"
      },
      {
        "slug": "lias",
        "symbol": "LIAS",
        "hgnc": "HGNC:16429",
        "name": "lipoic acid synthetase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lias"
      },
      {
        "slug": "lrpprc",
        "symbol": "LRPPRC",
        "hgnc": "HGNC:15714",
        "name": "leucine rich pentatricopeptide repeat containing",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lrpprc"
      },
      {
        "slug": "lyrm4",
        "symbol": "LYRM4",
        "hgnc": "HGNC:21365",
        "name": "LYR motif containing 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lyrm4"
      },
      {
        "slug": "lyrm7",
        "symbol": "LYRM7",
        "hgnc": "HGNC:28072",
        "name": "LYR motif containing 7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lyrm7"
      },
      {
        "slug": "mars1",
        "symbol": "MARS1",
        "hgnc": "HGNC:6898",
        "name": "methionyl-tRNA synthetase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mars1"
      },
      {
        "slug": "micos13",
        "symbol": "MICOS13",
        "hgnc": "HGNC:33702",
        "name": "mitochondrial contact site and cristae organizing system subunit 13",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/micos13"
      },
      {
        "slug": "mipep",
        "symbol": "MIPEP",
        "hgnc": "HGNC:7104",
        "name": "mitochondrial intermediate peptidase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mipep"
      },
      {
        "slug": "mrps14",
        "symbol": "MRPS14",
        "hgnc": "HGNC:14049",
        "name": "mitochondrial ribosomal protein S14",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps14"
      },
      {
        "slug": "mrps16",
        "symbol": "MRPS16",
        "hgnc": "HGNC:14048",
        "name": "mitochondrial ribosomal protein S16",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps16"
      },
      {
        "slug": "mrps22",
        "symbol": "MRPS22",
        "hgnc": "HGNC:14508",
        "name": "mitochondrial ribosomal protein S22",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps22"
      },
      {
        "slug": "mrps34",
        "symbol": "MRPS34",
        "hgnc": "HGNC:16618",
        "name": "mitochondrial ribosomal protein S34",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps34"
      },
      {
        "slug": "mt-tn",
        "symbol": "MT-TN",
        "hgnc": "HGNC:7493",
        "name": "mitochondrially encoded tRNA-Asn (AAU/C)",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tn"
      },
      {
        "slug": "mt-ts1",
        "symbol": "MT-TS1",
        "hgnc": "HGNC:7497",
        "name": "mitochondrially encoded tRNA-Ser (UCN) 1",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/mt-ts1"
      },
      {
        "slug": "mto1",
        "symbol": "MTO1",
        "hgnc": "HGNC:19261",
        "name": "mitochondrial tRNA translation optimization 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mto1"
      },
      {
        "slug": "ndufa10",
        "symbol": "NDUFA10",
        "hgnc": "HGNC:7684",
        "name": "NADH:ubiquinone oxidoreductase subunit A10",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa10"
      },
      {
        "slug": "ndufa11",
        "symbol": "NDUFA11",
        "hgnc": "HGNC:20371",
        "name": "NADH:ubiquinone oxidoreductase subunit A11",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufa11"
      },
      {
        "slug": "ndufaf1",
        "symbol": "NDUFAF1",
        "hgnc": "HGNC:18828",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufaf1"
      },
      {
        "slug": "ndufaf5",
        "symbol": "NDUFAF5",
        "hgnc": "HGNC:15899",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 5",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufaf5"
      },
      {
        "slug": "ndufaf6",
        "symbol": "NDUFAF6",
        "hgnc": "HGNC:28625",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufaf6"
      },
      {
        "slug": "ndufaf8",
        "symbol": "NDUFAF8",
        "hgnc": "HGNC:33551",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 8",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufaf8"
      },
      {
        "slug": "ndufb10",
        "symbol": "NDUFB10",
        "hgnc": "HGNC:7696",
        "name": "NADH:ubiquinone oxidoreductase subunit B10",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufb10"
      },
      {
        "slug": "ndufb3",
        "symbol": "NDUFB3",
        "hgnc": "HGNC:7698",
        "name": "NADH:ubiquinone oxidoreductase subunit B3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufb3"
      },
      {
        "slug": "ndufb7",
        "symbol": "NDUFB7",
        "hgnc": "HGNC:7702",
        "name": "NADH:ubiquinone oxidoreductase subunit B7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufb7"
      },
      {
        "slug": "ndufs2",
        "symbol": "NDUFS2",
        "hgnc": "HGNC:7708",
        "name": "NADH:ubiquinone oxidoreductase core subunit S2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufs2"
      },
      {
        "slug": "ndufs4",
        "symbol": "NDUFS4",
        "hgnc": "HGNC:7711",
        "name": "NADH:ubiquinone oxidoreductase subunit S4",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufs4"
      },
      {
        "slug": "ndufs6",
        "symbol": "NDUFS6",
        "hgnc": "HGNC:7713",
        "name": "NADH:ubiquinone oxidoreductase subunit S6",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufs6"
      },
      {
        "slug": "ndufv2",
        "symbol": "NDUFV2",
        "hgnc": "HGNC:7717",
        "name": "NADH:ubiquinone oxidoreductase core subunit V2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufv2"
      },
      {
        "slug": "nfu1",
        "symbol": "NFU1",
        "hgnc": "HGNC:16287",
        "name": "NFU1 iron-sulfur cluster scaffold",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nfu1"
      },
      {
        "slug": "nsun3",
        "symbol": "NSUN3",
        "hgnc": "HGNC:26208",
        "name": "NOP2/Sun RNA methyltransferase 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsun3"
      },
      {
        "slug": "pc",
        "symbol": "PC",
        "hgnc": "HGNC:8636",
        "name": "pyruvate carboxylase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pc"
      },
      {
        "slug": "pck1",
        "symbol": "PCK1",
        "hgnc": "HGNC:8724",
        "name": "phosphoenolpyruvate carboxykinase 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pck1"
      },
      {
        "slug": "pdha1",
        "symbol": "PDHA1",
        "hgnc": "HGNC:8806",
        "name": "pyruvate dehydrogenase E1 subunit alpha 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pdha1"
      },
      {
        "slug": "pdhb",
        "symbol": "PDHB",
        "hgnc": "HGNC:8808",
        "name": "pyruvate dehydrogenase E1 subunit beta",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pdhb"
      },
      {
        "slug": "pdp1",
        "symbol": "PDP1",
        "hgnc": "HGNC:9279",
        "name": "pyruvate dehydrogenase phosphatase catalytic subunit 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pdp1"
      },
      {
        "slug": "pet100",
        "symbol": "PET100",
        "hgnc": "HGNC:40038",
        "name": "PET100 cytochrome c oxidase chaperone",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pet100"
      },
      {
        "slug": "pnpla8",
        "symbol": "PNPLA8",
        "hgnc": "HGNC:28900",
        "name": "patatin like domain 8, phospholipase A2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pnpla8"
      },
      {
        "slug": "qrsl1",
        "symbol": "QRSL1",
        "hgnc": "HGNC:21020",
        "name": "glutaminyl-tRNA amidotransferase subunit QRSL1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/qrsl1"
      },
      {
        "slug": "rfc4",
        "symbol": "RFC4",
        "hgnc": "HGNC:9972",
        "name": "replication factor C subunit 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfc4"
      },
      {
        "slug": "rmnd1",
        "symbol": "RMND1",
        "hgnc": "HGNC:21176",
        "name": "required for meiotic nuclear division 1 homolog",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rmnd1"
      },
      {
        "slug": "rrm2b",
        "symbol": "RRM2B",
        "hgnc": "HGNC:17296",
        "name": "ribonucleotide reductase regulatory TP53 inducible subunit M2B",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rrm2b"
      },
      {
        "slug": "sco1",
        "symbol": "SCO1",
        "hgnc": "HGNC:10603",
        "name": "synthesis of cytochrome C oxidase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sco1"
      },
      {
        "slug": "sco2",
        "symbol": "SCO2",
        "hgnc": "HGNC:10604",
        "name": "synthesis of cytochrome C oxidase 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sco2"
      },
      {
        "slug": "sdhd",
        "symbol": "SDHD",
        "hgnc": "HGNC:10683",
        "name": "succinate dehydrogenase complex subunit D",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhd"
      },
      {
        "slug": "sfxn4",
        "symbol": "SFXN4",
        "hgnc": "HGNC:16088",
        "name": "sideroflexin 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sfxn4"
      },
      {
        "slug": "slc25a19",
        "symbol": "SLC25A19",
        "hgnc": "HGNC:14409",
        "name": "solute carrier family 25 member 19",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a19"
      },
      {
        "slug": "slc25a4",
        "symbol": "SLC25A4",
        "hgnc": "HGNC:10990",
        "name": "solute carrier family 25 member 4",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc25a4"
      },
      {
        "slug": "slc25a42",
        "symbol": "SLC25A42",
        "hgnc": "HGNC:28380",
        "name": "solute carrier family 25 member 42",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a42"
      },
      {
        "slug": "slc37a4",
        "symbol": "SLC37A4",
        "hgnc": "HGNC:4061",
        "name": "solute carrier family 37 member 4",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/slc37a4"
      },
      {
        "slug": "slc52a1",
        "symbol": "SLC52A1",
        "hgnc": "HGNC:30225",
        "name": "solute carrier family 52 member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc52a1"
      },
      {
        "slug": "sqor",
        "symbol": "SQOR",
        "hgnc": "HGNC:20390",
        "name": "sulfide quinone oxidoreductase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sqor"
      },
      {
        "slug": "suclg1",
        "symbol": "SUCLG1",
        "hgnc": "HGNC:11449",
        "name": "succinate-CoA ligase GDP/ADP-forming subunit alpha",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/suclg1"
      },
      {
        "slug": "surf1",
        "symbol": "SURF1",
        "hgnc": "HGNC:11474",
        "name": "SURF1 cytochrome c oxidase assembly factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/surf1"
      },
      {
        "slug": "taco1",
        "symbol": "TACO1",
        "hgnc": "HGNC:24316",
        "name": "translational activator of cytochrome c oxidase I",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taco1"
      },
      {
        "slug": "tmem70",
        "symbol": "TMEM70",
        "hgnc": "HGNC:26050",
        "name": "transmembrane protein 70",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem70"
      },
      {
        "slug": "trmt10c",
        "symbol": "TRMT10C",
        "hgnc": "HGNC:26022",
        "name": "tRNA methyltransferase 10C, mitochondrial RNase P subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trmt10c"
      },
      {
        "slug": "trmt5",
        "symbol": "TRMT5",
        "hgnc": "HGNC:23141",
        "name": "tRNA methyltransferase 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trmt5"
      },
      {
        "slug": "uqcc2",
        "symbol": "UQCC2",
        "hgnc": "HGNC:21237",
        "name": "ubiquinol-cytochrome c reductase complex assembly factor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uqcc2"
      },
      {
        "slug": "uqcc3",
        "symbol": "UQCC3",
        "hgnc": "HGNC:34399",
        "name": "ubiquinol-cytochrome c reductase complex assembly factor 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uqcc3"
      },
      {
        "slug": "uqcrfs1",
        "symbol": "UQCRFS1",
        "hgnc": "HGNC:12587",
        "name": "ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uqcrfs1"
      },
      {
        "slug": "vars2",
        "symbol": "VARS2",
        "hgnc": "HGNC:21642",
        "name": "valyl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vars2"
      },
      {
        "slug": "yars2",
        "symbol": "YARS2",
        "hgnc": "HGNC:24249",
        "name": "tyrosyl-tRNA synthetase 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/yars2"
      },
      {
        "slug": "dld",
        "symbol": "DLD",
        "hgnc": "HGNC:2898",
        "name": "dihydrolipoamide dehydrogenase",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dld"
      },
      {
        "slug": "fbp1",
        "symbol": "FBP1",
        "hgnc": "HGNC:3606",
        "name": "fructose-bisphosphatase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbp1"
      },
      {
        "slug": "hsd17b10",
        "symbol": "HSD17B10",
        "hgnc": "HGNC:4800",
        "name": "hydroxysteroid 17-beta dehydrogenase 10",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/hsd17b10"
      },
      {
        "slug": "iars2",
        "symbol": "IARS2",
        "hgnc": "HGNC:29685",
        "name": "isoleucyl-tRNA synthetase 2, mitochondrial",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/iars2"
      },
      {
        "slug": "mpv17",
        "symbol": "MPV17",
        "hgnc": "HGNC:7224",
        "name": "mitochondrial inner membrane protein MPV17",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpv17"
      },
      {
        "slug": "mt-co1",
        "symbol": "MT-CO1",
        "hgnc": "HGNC:7419",
        "name": "mitochondrially encoded cytochrome c oxidase I",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-co1"
      },
      {
        "slug": "mt-co2",
        "symbol": "MT-CO2",
        "hgnc": "HGNC:7421",
        "name": "mitochondrially encoded cytochrome c oxidase II",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-co2"
      },
      {
        "slug": "mt-co3",
        "symbol": "MT-CO3",
        "hgnc": "HGNC:7422",
        "name": "mitochondrially encoded cytochrome c oxidase III",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-co3"
      },
      {
        "slug": "mt-nd1",
        "symbol": "MT-ND1",
        "hgnc": "HGNC:7455",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/mt-nd1"
      },
      {
        "slug": "mt-nd2",
        "symbol": "MT-ND2",
        "hgnc": "HGNC:7456",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd2"
      },
      {
        "slug": "mt-nd3",
        "symbol": "MT-ND3",
        "hgnc": "HGNC:7458",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd3"
      },
      {
        "slug": "mt-nd4",
        "symbol": "MT-ND4",
        "hgnc": "HGNC:7459",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-nd4"
      },
      {
        "slug": "mt-nd5",
        "symbol": "MT-ND5",
        "hgnc": "HGNC:7461",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-nd5"
      },
      {
        "slug": "mt-nd6",
        "symbol": "MT-ND6",
        "hgnc": "HGNC:7462",
        "name": "mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-nd6"
      },
      {
        "slug": "mt-tf",
        "symbol": "MT-TF",
        "hgnc": "HGNC:7481",
        "name": "mitochondrially encoded tRNA-Phe (UUU/C)",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-tf"
      },
      {
        "slug": "mt-th",
        "symbol": "MT-TH",
        "hgnc": "HGNC:7487",
        "name": "mitochondrially encoded tRNA-His (CAU/C)",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-th"
      },
      {
        "slug": "mt-tl1",
        "symbol": "MT-TL1",
        "hgnc": "HGNC:7490",
        "name": "mitochondrially encoded tRNA-Leu (UUA/G) 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-tl1"
      },
      {
        "slug": "mt-tq",
        "symbol": "MT-TQ",
        "hgnc": "HGNC:7495",
        "name": "mitochondrially encoded tRNA-Gln (CAA/G)",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-tq"
      },
      {
        "slug": "mt-ts2",
        "symbol": "MT-TS2",
        "hgnc": "HGNC:7498",
        "name": "mitochondrially encoded tRNA-Ser (AGU/C) 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-ts2"
      },
      {
        "slug": "mt-tw",
        "symbol": "MT-TW",
        "hgnc": "HGNC:7501",
        "name": "mitochondrially encoded tRNA-Trp (UGA/G)",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-tw"
      },
      {
        "slug": "ndufa1",
        "symbol": "NDUFA1",
        "hgnc": "HGNC:7683",
        "name": "NADH:ubiquinone oxidoreductase subunit A1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa1"
      },
      {
        "slug": "ndufa6",
        "symbol": "NDUFA6",
        "hgnc": "HGNC:7690",
        "name": "NADH:ubiquinone oxidoreductase subunit A6",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufa6"
      },
      {
        "slug": "ndufa9",
        "symbol": "NDUFA9",
        "hgnc": "HGNC:7693",
        "name": "NADH:ubiquinone oxidoreductase subunit A9",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa9"
      },
      {
        "slug": "ndufaf2",
        "symbol": "NDUFAF2",
        "hgnc": "HGNC:28086",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufaf2"
      },
      {
        "slug": "ndufaf3",
        "symbol": "NDUFAF3",
        "hgnc": "HGNC:29918",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufaf3"
      },
      {
        "slug": "ndufaf4",
        "symbol": "NDUFAF4",
        "hgnc": "HGNC:21034",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufaf4"
      },
      {
        "slug": "ndufb11",
        "symbol": "NDUFB11",
        "hgnc": "HGNC:20372",
        "name": "NADH:ubiquinone oxidoreductase subunit B11",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufb11"
      },
      {
        "slug": "ndufb9",
        "symbol": "NDUFB9",
        "hgnc": "HGNC:7704",
        "name": "NADH:ubiquinone oxidoreductase subunit B9",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufb9"
      },
      {
        "slug": "ndufs1",
        "symbol": "NDUFS1",
        "hgnc": "HGNC:7707",
        "name": "NADH:ubiquinone oxidoreductase core subunit S1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufs1"
      },
      {
        "slug": "ndufs3",
        "symbol": "NDUFS3",
        "hgnc": "HGNC:7710",
        "name": "NADH:ubiquinone oxidoreductase core subunit S3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ndufs3"
      },
      {
        "slug": "ndufs7",
        "symbol": "NDUFS7",
        "hgnc": "HGNC:7714",
        "name": "NADH:ubiquinone oxidoreductase core subunit S7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufs7"
      },
      {
        "slug": "ndufs8",
        "symbol": "NDUFS8",
        "hgnc": "HGNC:7715",
        "name": "NADH:ubiquinone oxidoreductase core subunit S8",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufs8"
      },
      {
        "slug": "ndufv1",
        "symbol": "NDUFV1",
        "hgnc": "HGNC:7716",
        "name": "NADH:ubiquinone oxidoreductase core subunit V1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufv1"
      },
      {
        "slug": "nubpl",
        "symbol": "NUBPL",
        "hgnc": "HGNC:20278",
        "name": "NUBP iron-sulfur cluster assembly factor, mitochondrial",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nubpl"
      },
      {
        "slug": "pus1",
        "symbol": "PUS1",
        "hgnc": "HGNC:15508",
        "name": "pseudouridine synthase 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pus1"
      },
      {
        "slug": "serac1",
        "symbol": "SERAC1",
        "hgnc": "HGNC:21061",
        "name": "serine active site containing 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/serac1"
      },
      {
        "slug": "slc25a13",
        "symbol": "SLC25A13",
        "hgnc": "HGNC:10983",
        "name": "solute carrier family 25 member 13",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a13"
      },
      {
        "slug": "slc25a3",
        "symbol": "SLC25A3",
        "hgnc": "HGNC:10989",
        "name": "solute carrier family 25 member 3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc25a3"
      },
      {
        "slug": "tango2",
        "symbol": "TANGO2",
        "hgnc": "HGNC:25439",
        "name": "transport and golgi organization 2 homolog",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tango2"
      },
      {
        "slug": "timmdc1",
        "symbol": "TIMMDC1",
        "hgnc": "HGNC:1321",
        "name": "translocase of inner mitochondrial membrane domain containing 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/timmdc1"
      },
      {
        "slug": "tkfc",
        "symbol": "TKFC",
        "hgnc": "HGNC:24552",
        "name": "triokinase and FMN cyclase",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tkfc"
      },
      {
        "slug": "tmem126b",
        "symbol": "TMEM126B",
        "hgnc": "HGNC:30883",
        "name": "transmembrane protein 126B",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tmem126b"
      },
      {
        "slug": "aars2",
        "symbol": "AARS2",
        "hgnc": "HGNC:21022",
        "name": "alanyl-tRNA synthetase 2, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aars2"
      },
      {
        "slug": "atp5f1a",
        "symbol": "ATP5F1A",
        "hgnc": "HGNC:823",
        "name": "ATP synthase F1 subunit alpha",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atp5f1a"
      },
      {
        "slug": "atp5f1d",
        "symbol": "ATP5F1D",
        "hgnc": "HGNC:837",
        "name": "ATP synthase F1 subunit delta",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atp5f1d"
      },
      {
        "slug": "atp5f1e",
        "symbol": "ATP5F1E",
        "hgnc": "HGNC:838",
        "name": "ATP synthase F1 subunit epsilon",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atp5f1e"
      },
      {
        "slug": "atp5mk",
        "symbol": "ATP5MK",
        "hgnc": "HGNC:30889",
        "name": "ATP synthase membrane subunit k",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp5mk"
      },
      {
        "slug": "atp5po",
        "symbol": "ATP5PO",
        "hgnc": "HGNC:850",
        "name": "ATP synthase peripheral stalk subunit OSCP",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp5po"
      },
      {
        "slug": "atpaf2",
        "symbol": "ATPAF2",
        "hgnc": "HGNC:18802",
        "name": "ATP synthase mitochondrial F1 complex assembly factor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atpaf2"
      },
      {
        "slug": "c1qbp",
        "symbol": "C1QBP",
        "hgnc": "HGNC:1243",
        "name": "complement C1q binding protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c1qbp"
      },
      {
        "slug": "camkmt",
        "symbol": "CAMKMT",
        "hgnc": "HGNC:26276",
        "name": "calmodulin-lysine N-methyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/camkmt"
      },
      {
        "slug": "coa8",
        "symbol": "COA8",
        "hgnc": "HGNC:20492",
        "name": "cytochrome c oxidase assembly factor 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coa8"
      },
      {
        "slug": "dap3",
        "symbol": "DAP3",
        "hgnc": "HGNC:2673",
        "name": "death associated protein 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dap3"
      },
      {
        "slug": "elac2",
        "symbol": "ELAC2",
        "hgnc": "HGNC:14198",
        "name": "elaC ribonuclease Z 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elac2"
      },
      {
        "slug": "gfer",
        "symbol": "GFER",
        "hgnc": "HGNC:4236",
        "name": "growth factor, augmenter of liver regeneration",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gfer"
      },
      {
        "slug": "gfm1",
        "symbol": "GFM1",
        "hgnc": "HGNC:13780",
        "name": "G elongation factor mitochondrial 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gfm1"
      },
      {
        "slug": "hadha",
        "symbol": "HADHA",
        "hgnc": "HGNC:4801",
        "name": "hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hadha"
      },
      {
        "slug": "ivd",
        "symbol": "IVD",
        "hgnc": "HGNC:6186",
        "name": "isovaleryl-CoA dehydrogenase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ivd"
      },
      {
        "slug": "lig3",
        "symbol": "LIG3",
        "hgnc": "HGNC:6600",
        "name": "DNA ligase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lig3"
      },
      {
        "slug": "lipt2",
        "symbol": "LIPT2",
        "hgnc": "HGNC:37216",
        "name": "lipoyl(octanoyl) transferase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lipt2"
      },
      {
        "slug": "lonp1",
        "symbol": "LONP1",
        "hgnc": "HGNC:9479",
        "name": "lon peptidase 1, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lonp1"
      },
      {
        "slug": "mrps7",
        "symbol": "MRPS7",
        "hgnc": "HGNC:14499",
        "name": "mitochondrial ribosomal protein S7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps7"
      },
      {
        "slug": "mt-atp6",
        "symbol": "MT-ATP6",
        "hgnc": "HGNC:7414",
        "name": "mitochondrially encoded ATP synthase membrane subunit 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-atp6"
      },
      {
        "slug": "mt-atp8",
        "symbol": "MT-ATP8",
        "hgnc": "HGNC:7415",
        "name": "mitochondrially encoded ATP synthase membrane subunit 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-atp8"
      },
      {
        "slug": "ndufa8",
        "symbol": "NDUFA8",
        "hgnc": "HGNC:7692",
        "name": "NADH:ubiquinone oxidoreductase subunit A8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa8"
      },
      {
        "slug": "pck2",
        "symbol": "PCK2",
        "hgnc": "HGNC:8725",
        "name": "phosphoenolpyruvate carboxykinase 2, mitochondrial",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pck2"
      },
      {
        "slug": "pdhx",
        "symbol": "PDHX",
        "hgnc": "HGNC:21350",
        "name": "pyruvate dehydrogenase complex component X",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pdhx"
      },
      {
        "slug": "phka2",
        "symbol": "PHKA2",
        "hgnc": "HGNC:8926",
        "name": "phosphorylase kinase regulatory subunit alpha 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/phka2"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "ppm1b",
        "symbol": "PPM1B",
        "hgnc": "HGNC:9276",
        "name": "protein phosphatase, Mg2+/Mn2+ dependent 1B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppm1b"
      },
      {
        "slug": "prepl",
        "symbol": "PREPL",
        "hgnc": "HGNC:30228",
        "name": "prolyl endopeptidase like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prepl"
      },
      {
        "slug": "slc3a1",
        "symbol": "SLC3A1",
        "hgnc": "HGNC:11025",
        "name": "solute carrier family 3 member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc3a1"
      },
      {
        "slug": "tafazzin",
        "symbol": "TAFAZZIN",
        "hgnc": "HGNC:11577",
        "name": "tafazzin, phospholipid-lysophospholipid transacylase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tafazzin"
      },
      {
        "slug": "tpk1",
        "symbol": "TPK1",
        "hgnc": "HGNC:17358",
        "name": "thiamin pyrophosphokinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tpk1"
      },
      {
        "slug": "trnt1",
        "symbol": "TRNT1",
        "hgnc": "HGNC:17341",
        "name": "tRNA nucleotidyl transferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trnt1"
      },
      {
        "slug": "tymp",
        "symbol": "TYMP",
        "hgnc": "HGNC:3148",
        "name": "thymidine phosphorylase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tymp"
      },
      {
        "slug": "wars2",
        "symbol": "WARS2",
        "hgnc": "HGNC:12730",
        "name": "tryptophanyl tRNA synthetase 2, mitochondrial",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/wars2"
      },
      {
        "slug": "coq8a",
        "symbol": "COQ8A",
        "hgnc": "HGNC:16812",
        "name": "coenzyme Q8A",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/coq8a"
      },
      {
        "slug": "hadh",
        "symbol": "HADH",
        "hgnc": "HGNC:4799",
        "name": "hydroxyacyl-CoA dehydrogenase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hadh"
      },
      {
        "slug": "pmpca",
        "symbol": "PMPCA",
        "hgnc": "HGNC:18667",
        "name": "peptidase, mitochondrial processing subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pmpca"
      },
      {
        "slug": "ryr1",
        "symbol": "RYR1",
        "hgnc": "HGNC:10483",
        "name": "ryanodine receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ryr1"
      },
      {
        "slug": "usp18",
        "symbol": "USP18",
        "hgnc": "HGNC:12616",
        "name": "ubiquitin specific peptidase 18",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/usp18"
      },
      {
        "slug": "aldh7a1",
        "symbol": "ALDH7A1",
        "hgnc": "HGNC:877",
        "name": "aldehyde dehydrogenase 7 family member A1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh7a1"
      },
      {
        "slug": "fh",
        "symbol": "FH",
        "hgnc": "HGNC:3700",
        "name": "fumarate hydratase",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fh"
      },
      {
        "slug": "mt-cyb",
        "symbol": "MT-CYB",
        "hgnc": "HGNC:7427",
        "name": "mitochondrially encoded cytochrome b",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mt-cyb"
      },
      {
        "slug": "phkb",
        "symbol": "PHKB",
        "hgnc": "HGNC:8927",
        "name": "phosphorylase kinase regulatory subunit beta",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phkb"
      },
      {
        "slug": "phkg2",
        "symbol": "PHKG2",
        "hgnc": "HGNC:8931",
        "name": "phosphorylase kinase catalytic subunit gamma 2",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/phkg2"
      },
      {
        "slug": "plpbp",
        "symbol": "PLPBP",
        "hgnc": "HGNC:9457",
        "name": "pyridoxal phosphate binding protein",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plpbp"
      },
      {
        "slug": "aldob",
        "symbol": "ALDOB",
        "hgnc": "HGNC:417",
        "name": "aldolase, fructose-bisphosphate B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldob"
      },
      {
        "slug": "aptx",
        "symbol": "APTX",
        "hgnc": "HGNC:15984",
        "name": "aprataxin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aptx"
      },
      {
        "slug": "bckdha",
        "symbol": "BCKDHA",
        "hgnc": "HGNC:986",
        "name": "branched chain keto acid dehydrogenase E1 subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bckdha"
      },
      {
        "slug": "ca5a",
        "symbol": "CA5A",
        "hgnc": "HGNC:1377",
        "name": "carbonic anhydrase 5A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ca5a"
      },
      {
        "slug": "coq2",
        "symbol": "COQ2",
        "hgnc": "HGNC:25223",
        "name": "coenzyme Q2, polyprenyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coq2"
      },
      {
        "slug": "dlat",
        "symbol": "DLAT",
        "hgnc": "HGNC:2896",
        "name": "dihydrolipoamide S-acetyltransferase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dlat"
      },
      {
        "slug": "iscu",
        "symbol": "ISCU",
        "hgnc": "HGNC:29882",
        "name": "iron-sulfur cluster assembly enzyme",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/iscu"
      },
      {
        "slug": "lars1",
        "symbol": "LARS1",
        "hgnc": "HGNC:6512",
        "name": "leucyl-tRNA synthetase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lars1"
      },
      {
        "slug": "lipt1",
        "symbol": "LIPT1",
        "hgnc": "HGNC:29569",
        "name": "lipoyltransferase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lipt1"
      },
      {
        "slug": "mlycd",
        "symbol": "MLYCD",
        "hgnc": "HGNC:7150",
        "name": "malonyl-CoA decarboxylase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mlycd"
      },
      {
        "slug": "mpc1",
        "symbol": "MPC1",
        "hgnc": "HGNC:21606",
        "name": "mitochondrial pyruvate carrier 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpc1"
      },
      {
        "slug": "mt-tc",
        "symbol": "MT-TC",
        "hgnc": "HGNC:7477",
        "name": "mitochondrially encoded tRNA-Cys (UGU/C)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tc"
      },
      {
        "slug": "mt-tk",
        "symbol": "MT-TK",
        "hgnc": "HGNC:7489",
        "name": "mitochondrially encoded tRNA-Lys (AAA/G)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tk"
      },
      {
        "slug": "mt-tl2",
        "symbol": "MT-TL2",
        "hgnc": "HGNC:7491",
        "name": "mitochondrially encoded tRNA-Leu (CUN) 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tl2"
      },
      {
        "slug": "mt-tt",
        "symbol": "MT-TT",
        "hgnc": "HGNC:7499",
        "name": "mitochondrially encoded tRNA-Thr (ACN)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tt"
      },
      {
        "slug": "mt-tv",
        "symbol": "MT-TV",
        "hgnc": "HGNC:7500",
        "name": "mitochondrially encoded tRNA-Val (GUN)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tv"
      },
      {
        "slug": "naxe",
        "symbol": "NAXE",
        "hgnc": "HGNC:18453",
        "name": "NAD(P)HX epimerase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/naxe"
      },
      {
        "slug": "pcca",
        "symbol": "PCCA",
        "hgnc": "HGNC:8653",
        "name": "propionyl-CoA carboxylase subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcca"
      },
      {
        "slug": "pccb",
        "symbol": "PCCB",
        "hgnc": "HGNC:8654",
        "name": "propionyl-CoA carboxylase subunit beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pccb"
      },
      {
        "slug": "sucla2",
        "symbol": "SUCLA2",
        "hgnc": "HGNC:11448",
        "name": "succinate-CoA ligase ADP-forming subunit beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sucla2"
      },
      {
        "slug": "tk2",
        "symbol": "TK2",
        "hgnc": "HGNC:11831",
        "name": "thymidine kinase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tk2"
      },
      {
        "slug": "trmu",
        "symbol": "TRMU",
        "hgnc": "HGNC:25481",
        "name": "tRNA mitochondrial 2-thiouridylase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trmu"
      },
      {
        "slug": "tsfm",
        "symbol": "TSFM",
        "hgnc": "HGNC:12367",
        "name": "Ts translation elongation factor, mitochondrial",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tsfm"
      },
      {
        "slug": "tufm",
        "symbol": "TUFM",
        "hgnc": "HGNC:12420",
        "name": "Tu translation elongation factor, mitochondrial",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tufm"
      }
    ]
  }
}