{
  "url": "https://dantelabs.com/traits/increased-total-b-cell-count",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "increased-total-b-cell-count",
    "id": "HP:0005404",
    "name": "Increased total B cell count",
    "definition": "The absolute number of B cells in the blood, per microlitre is above the upper limit of normal of the reference range for the appropriate sex and age-group.",
    "synonyms": [
      "B cell lymphocytosis",
      "Increase in B cell count",
      "Increase in B cell number",
      "Increased number of B cells"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-total-b-cell-count",
        "name": "Abnormal total B cell count",
        "url": "https://dantelabs.com/traits/abnormal-total-b-cell-count"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "card11",
        "symbol": "CARD11",
        "hgnc": "HGNC:16393",
        "name": "caspase recruitment domain family member 11",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/card11"
      },
      {
        "slug": "ikbkg",
        "symbol": "IKBKG",
        "hgnc": "HGNC:5961",
        "name": "inhibitor of nuclear factor kappa B kinase regulatory subunit gamma",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ikbkg"
      },
      {
        "slug": "il27ra",
        "symbol": "IL27RA",
        "hgnc": "HGNC:17290",
        "name": "interleukin 27 receptor subunit alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il27ra"
      },
      {
        "slug": "prkcd",
        "symbol": "PRKCD",
        "hgnc": "HGNC:9399",
        "name": "protein kinase C delta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkcd"
      },
      {
        "slug": "ptprc",
        "symbol": "PTPRC",
        "hgnc": "HGNC:9666",
        "name": "protein tyrosine phosphatase receptor type C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptprc"
      },
      {
        "slug": "casp10",
        "symbol": "CASP10",
        "hgnc": "HGNC:1500",
        "name": "caspase 10",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/casp10"
      },
      {
        "slug": "fas",
        "symbol": "FAS",
        "hgnc": "HGNC:11920",
        "name": "Fas cell surface death receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fas"
      },
      {
        "slug": "faslg",
        "symbol": "FASLG",
        "hgnc": "HGNC:11936",
        "name": "Fas ligand",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/faslg"
      },
      {
        "slug": "lyn",
        "symbol": "LYN",
        "hgnc": "HGNC:6735",
        "name": "LYN proto-oncogene, Src family tyrosine kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lyn"
      },
      {
        "slug": "map3k14",
        "symbol": "MAP3K14",
        "hgnc": "HGNC:6853",
        "name": "mitogen-activated protein kinase kinase kinase 14",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map3k14"
      },
      {
        "slug": "nckap1l",
        "symbol": "NCKAP1L",
        "hgnc": "HGNC:4862",
        "name": "NCK associated protein 1 like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nckap1l"
      },
      {
        "slug": "nfkbia",
        "symbol": "NFKBIA",
        "hgnc": "HGNC:7797",
        "name": "NFKB inhibitor alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfkbia"
      }
    ]
  }
}