{
  "url": "https://dantelabs.com/traits/increased-circulating-gonadotropin-level",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "increased-circulating-gonadotropin-level",
    "id": "HP:0000837",
    "name": "Increased circulating gonadotropin level",
    "definition": "Overproduction of gonadotropins (FSH, LH) by the anterior pituitary gland.",
    "synonyms": [
      "Elevated gonadotropins",
      "Elevated serum gonadotropins",
      "Gonadotropin excess"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      },
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-gonadotropin-concentration",
        "name": "Abnormal circulating gonadotropin concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-gonadotropin-concentration"
      },
      {
        "slug": "hyperpituitarism",
        "name": "Hyperpituitarism",
        "url": "https://dantelabs.com/traits/hyperpituitarism"
      }
    ],
    "narrower": [
      {
        "slug": "elevated-circulating-follicle-stimulating-hormone-level",
        "name": "Elevated circulating follicle stimulating hormone level",
        "genes": 62,
        "url": "https://dantelabs.com/traits/elevated-circulating-follicle-stimulating-hormone-level"
      },
      {
        "slug": "elevated-circulating-luteinizing-hormone-level",
        "name": "Elevated circulating luteinizing hormone level",
        "genes": 47,
        "url": "https://dantelabs.com/traits/elevated-circulating-luteinizing-hormone-level"
      }
    ],
    "genes": [
      {
        "slug": "bmp15",
        "symbol": "BMP15",
        "hgnc": "HGNC:1068",
        "name": "bone morphogenetic protein 15",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmp15"
      },
      {
        "slug": "bnc1",
        "symbol": "BNC1",
        "hgnc": "HGNC:1081",
        "name": "basonuclin zinc finger protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bnc1"
      },
      {
        "slug": "catip",
        "symbol": "CATIP",
        "hgnc": "HGNC:25062",
        "name": "ciliogenesis associated TTC17 interacting protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/catip"
      },
      {
        "slug": "ccdc34",
        "symbol": "CCDC34",
        "hgnc": "HGNC:25079",
        "name": "coiled-coil domain containing 34",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc34"
      },
      {
        "slug": "cftr",
        "symbol": "CFTR",
        "hgnc": "HGNC:1884",
        "name": "CF transmembrane conductance regulator",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cftr"
      },
      {
        "slug": "ct55",
        "symbol": "CT55",
        "hgnc": "HGNC:26047",
        "name": "cancer/testis antigen 55",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ct55"
      },
      {
        "slug": "cyp17a1",
        "symbol": "CYP17A1",
        "hgnc": "HGNC:2593",
        "name": "cytochrome P450 family 17 subfamily A member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp17a1"
      },
      {
        "slug": "dhh",
        "symbol": "DHH",
        "hgnc": "HGNC:2865",
        "name": "desert hedgehog signaling molecule",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhh"
      },
      {
        "slug": "dhx37",
        "symbol": "DHX37",
        "hgnc": "HGNC:17210",
        "name": "DEAH-box helicase 37",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhx37"
      },
      {
        "slug": "dnah10",
        "symbol": "DNAH10",
        "hgnc": "HGNC:2941",
        "name": "dynein axonemal heavy chain 10",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah10"
      },
      {
        "slug": "dnhd1",
        "symbol": "DNHD1",
        "hgnc": "HGNC:26532",
        "name": "dynein heavy chain domain 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnhd1"
      },
      {
        "slug": "esr1",
        "symbol": "ESR1",
        "hgnc": "HGNC:3467",
        "name": "estrogen receptor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/esr1"
      },
      {
        "slug": "fancm",
        "symbol": "FANCM",
        "hgnc": "HGNC:23168",
        "name": "FA complementation group M",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fancm"
      },
      {
        "slug": "fbxo43",
        "symbol": "FBXO43",
        "hgnc": "HGNC:28521",
        "name": "F-box protein 43",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo43"
      },
      {
        "slug": "figla",
        "symbol": "FIGLA",
        "hgnc": "HGNC:24669",
        "name": "folliculogenesis specific bHLH transcription factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/figla"
      },
      {
        "slug": "fshr",
        "symbol": "FSHR",
        "hgnc": "HGNC:3969",
        "name": "follicle stimulating hormone receptor",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/fshr"
      },
      {
        "slug": "gata4",
        "symbol": "GATA4",
        "hgnc": "HGNC:4173",
        "name": "GATA binding protein 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata4"
      },
      {
        "slug": "gcna",
        "symbol": "GCNA",
        "hgnc": "HGNC:15805",
        "name": "germ cell nuclear acidic peptidase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gcna"
      },
      {
        "slug": "klhl10",
        "symbol": "KLHL10",
        "hgnc": "HGNC:18829",
        "name": "kelch like family member 10",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klhl10"
      },
      {
        "slug": "lars2",
        "symbol": "LARS2",
        "hgnc": "HGNC:17095",
        "name": "leucyl-tRNA synthetase 2, mitochondrial",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lars2"
      },
      {
        "slug": "map3k1",
        "symbol": "MAP3K1",
        "hgnc": "HGNC:6848",
        "name": "mitogen-activated protein kinase kinase kinase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map3k1"
      },
      {
        "slug": "meiob",
        "symbol": "MEIOB",
        "hgnc": "HGNC:28569",
        "name": "meiosis specific with OB-fold",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/meiob"
      },
      {
        "slug": "mov10l1",
        "symbol": "MOV10L1",
        "hgnc": "HGNC:7201",
        "name": "Mov10 like RNA helicase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mov10l1"
      },
      {
        "slug": "mrps22",
        "symbol": "MRPS22",
        "hgnc": "HGNC:14508",
        "name": "mitochondrial ribosomal protein S22",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps22"
      },
      {
        "slug": "msh4",
        "symbol": "MSH4",
        "hgnc": "HGNC:7327",
        "name": "mutS homolog 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msh4"
      },
      {
        "slug": "msh5",
        "symbol": "MSH5",
        "hgnc": "HGNC:7328",
        "name": "mutS homolog 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msh5"
      },
      {
        "slug": "nanos1",
        "symbol": "NANOS1",
        "hgnc": "HGNC:23044",
        "name": "nanos C2HC-type zinc finger 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nanos1"
      },
      {
        "slug": "nr0b1",
        "symbol": "NR0B1",
        "hgnc": "HGNC:7960",
        "name": "nuclear receptor subfamily 0 group B member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr0b1"
      },
      {
        "slug": "nr5a1",
        "symbol": "NR5A1",
        "hgnc": "HGNC:7983",
        "name": "nuclear receptor subfamily 5 group A member 1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/nr5a1"
      },
      {
        "slug": "nup107",
        "symbol": "NUP107",
        "hgnc": "HGNC:29914",
        "name": "nucleoporin 107",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nup107"
      },
      {
        "slug": "pdha2",
        "symbol": "PDHA2",
        "hgnc": "HGNC:8807",
        "name": "pyruvate dehydrogenase E1 subunit alpha 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdha2"
      },
      {
        "slug": "pnldc1",
        "symbol": "PNLDC1",
        "hgnc": "HGNC:21185",
        "name": "PARN like ribonuclease domain containing exonuclease 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pnldc1"
      },
      {
        "slug": "polr3h",
        "symbol": "POLR3H",
        "hgnc": "HGNC:30349",
        "name": "RNA polymerase III subunit H",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr3h"
      },
      {
        "slug": "psmc3ip",
        "symbol": "PSMC3IP",
        "hgnc": "HGNC:17928",
        "name": "PSMC3 interacting protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmc3ip"
      },
      {
        "slug": "rbbp7",
        "symbol": "RBBP7",
        "hgnc": "HGNC:9890",
        "name": "RB binding protein 7, chromatin remodeling factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbbp7"
      },
      {
        "slug": "rnf212",
        "symbol": "RNF212",
        "hgnc": "HGNC:27729",
        "name": "ring finger protein 212",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf212"
      },
      {
        "slug": "rpl10l",
        "symbol": "RPL10L",
        "hgnc": "HGNC:17976",
        "name": "ribosomal protein L10 like",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpl10l"
      },
      {
        "slug": "shoc1",
        "symbol": "SHOC1",
        "hgnc": "HGNC:26535",
        "name": "shortage in chiasmata 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/shoc1"
      },
      {
        "slug": "sohlh1",
        "symbol": "SOHLH1",
        "hgnc": "HGNC:27845",
        "name": "spermatogenesis and oogenesis specific basic helix-loop-helix 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sohlh1"
      },
      {
        "slug": "sox9",
        "symbol": "SOX9",
        "hgnc": "HGNC:11204",
        "name": "SRY-box transcription factor 9",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox9"
      },
      {
        "slug": "spag17",
        "symbol": "SPAG17",
        "hgnc": "HGNC:26620",
        "name": "sperm associated antigen 17",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spag17"
      },
      {
        "slug": "spidr",
        "symbol": "SPIDR",
        "hgnc": "HGNC:28971",
        "name": "scaffold protein involved in DNA repair",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spidr"
      },
      {
        "slug": "spink2",
        "symbol": "SPINK2",
        "hgnc": "HGNC:11245",
        "name": "serine peptidase inhibitor Kazal type 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spink2"
      },
      {
        "slug": "sry",
        "symbol": "SRY",
        "hgnc": "HGNC:11311",
        "name": "sex determining region Y",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sry"
      },
      {
        "slug": "stag3",
        "symbol": "STAG3",
        "hgnc": "HGNC:11356",
        "name": "STAG3 cohesin complex component",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stag3"
      },
      {
        "slug": "syce1",
        "symbol": "SYCE1",
        "hgnc": "HGNC:28852",
        "name": "synaptonemal complex central element protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/syce1"
      },
      {
        "slug": "sycp3",
        "symbol": "SYCP3",
        "hgnc": "HGNC:18130",
        "name": "synaptonemal complex protein 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sycp3"
      },
      {
        "slug": "taf4b",
        "symbol": "TAF4B",
        "hgnc": "HGNC:11538",
        "name": "TATA-box binding protein associated factor 4b",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taf4b"
      },
      {
        "slug": "tdrd9",
        "symbol": "TDRD9",
        "hgnc": "HGNC:20122",
        "name": "tudor domain containing 9",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tdrd9"
      },
      {
        "slug": "terb1",
        "symbol": "TERB1",
        "hgnc": "HGNC:26675",
        "name": "telomere repeat binding bouquet formation protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/terb1"
      },
      {
        "slug": "terb2",
        "symbol": "TERB2",
        "hgnc": "HGNC:28520",
        "name": "telomere repeat binding bouquet formation protein 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/terb2"
      },
      {
        "slug": "tex11",
        "symbol": "TEX11",
        "hgnc": "HGNC:11733",
        "name": "testis expressed 11",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tex11"
      },
      {
        "slug": "tex14",
        "symbol": "TEX14",
        "hgnc": "HGNC:11737",
        "name": "testis expressed 14, intercellular bridge forming factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tex14"
      },
      {
        "slug": "tex15",
        "symbol": "TEX15",
        "hgnc": "HGNC:11738",
        "name": "testis expressed 15, meiosis and synapsis associated",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tex15"
      },
      {
        "slug": "vamp7",
        "symbol": "VAMP7",
        "hgnc": "HGNC:11486",
        "name": "vesicle associated membrane protein 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vamp7"
      },
      {
        "slug": "wt1",
        "symbol": "WT1",
        "hgnc": "HGNC:12796",
        "name": "WT1 transcription factor",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/wt1"
      },
      {
        "slug": "wwox",
        "symbol": "WWOX",
        "hgnc": "HGNC:12799",
        "name": "WW domain containing oxidoreductase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wwox"
      },
      {
        "slug": "xrcc2",
        "symbol": "XRCC2",
        "hgnc": "HGNC:12829",
        "name": "X-ray repair cross complementing 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xrcc2"
      },
      {
        "slug": "zfpm2",
        "symbol": "ZFPM2",
        "hgnc": "HGNC:16700",
        "name": "zinc finger protein, FOG family member 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zfpm2"
      },
      {
        "slug": "zmynd15",
        "symbol": "ZMYND15",
        "hgnc": "HGNC:20997",
        "name": "zinc finger MYND-type containing 15",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmynd15"
      },
      {
        "slug": "zswim7",
        "symbol": "ZSWIM7",
        "hgnc": "HGNC:26993",
        "name": "zinc finger SWIM-type containing 7",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/zswim7"
      },
      {
        "slug": "pola1",
        "symbol": "POLA1",
        "hgnc": "HGNC:9173",
        "name": "DNA polymerase alpha 1, catalytic subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pola1"
      },
      {
        "slug": "cdh23",
        "symbol": "CDH23",
        "hgnc": "HGNC:13733",
        "name": "cadherin related 23",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdh23"
      },
      {
        "slug": "fmr1",
        "symbol": "FMR1",
        "hgnc": "HGNC:3775",
        "name": "fragile X messenger ribonucleoprotein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fmr1"
      },
      {
        "slug": "foxl2",
        "symbol": "FOXL2",
        "hgnc": "HGNC:1092",
        "name": "forkhead box L2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxl2"
      },
      {
        "slug": "hsd17b4",
        "symbol": "HSD17B4",
        "hgnc": "HGNC:5213",
        "name": "hydroxysteroid 17-beta dehydrogenase 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hsd17b4"
      },
      {
        "slug": "lhcgr",
        "symbol": "LHCGR",
        "hgnc": "HGNC:6585",
        "name": "luteinizing hormone/choriogonadotropin receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lhcgr"
      }
    ]
  }
}