{
  "url": "https://dantelabs.com/traits/hypoplastic-philtrum",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypoplastic-philtrum",
    "id": "HP:0005326",
    "name": "Hypoplastic philtrum",
    "definition": "Underdevelopment of the philtrum.",
    "synonyms": [
      "Small philtrum"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-philtrum",
        "name": "Abnormality of the philtrum",
        "url": "https://dantelabs.com/traits/abnormality-of-the-philtrum"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "map1b",
        "symbol": "MAP1B",
        "hgnc": "HGNC:6836",
        "name": "microtubule associated protein 1B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map1b"
      },
      {
        "slug": "pdcd6ip",
        "symbol": "PDCD6IP",
        "hgnc": "HGNC:8766",
        "name": "programmed cell death 6 interacting protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdcd6ip"
      },
      {
        "slug": "bckdk",
        "symbol": "BCKDK",
        "hgnc": "HGNC:16902",
        "name": "branched chain keto acid dehydrogenase kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bckdk"
      },
      {
        "slug": "ctcf",
        "symbol": "CTCF",
        "hgnc": "HGNC:13723",
        "name": "CCCTC-binding factor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctcf"
      },
      {
        "slug": "atrx",
        "symbol": "ATRX",
        "hgnc": "HGNC:886",
        "name": "ATRX chromatin remodeler",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atrx"
      },
      {
        "slug": "ext2",
        "symbol": "EXT2",
        "hgnc": "HGNC:3513",
        "name": "exostosin glycosyltransferase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ext2"
      }
    ]
  }
}