{
  "url": "https://dantelabs.com/traits/hyperkinetic-movements",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hyperkinetic-movements",
    "id": "HP:0002487",
    "name": "Hyperactive movements",
    "label": "Hyperkinetic movements",
    "definition": "Motor hyperactivity with excessive movement of muscles of the body as a whole.",
    "synonyms": [
      "Hyperkinesia",
      "Hyperkinesis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-movement",
        "name": "Abnormality of movement",
        "url": "https://dantelabs.com/traits/abnormality-of-movement"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "fbxl4",
        "symbol": "FBXL4",
        "hgnc": "HGNC:13601",
        "name": "F-box and leucine rich repeat protein 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxl4"
      },
      {
        "slug": "neurog1",
        "symbol": "NEUROG1",
        "hgnc": "HGNC:7764",
        "name": "neurogenin 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/neurog1"
      },
      {
        "slug": "opa1",
        "symbol": "OPA1",
        "hgnc": "HGNC:8140",
        "name": "OPA1 mitochondrial dynamin like GTPase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/opa1"
      },
      {
        "slug": "psap",
        "symbol": "PSAP",
        "hgnc": "HGNC:9498",
        "name": "prosaposin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psap"
      },
      {
        "slug": "scn2a",
        "symbol": "SCN2A",
        "hgnc": "HGNC:10588",
        "name": "sodium voltage-gated channel alpha subunit 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn2a"
      },
      {
        "slug": "sucla2",
        "symbol": "SUCLA2",
        "hgnc": "HGNC:11448",
        "name": "succinate-CoA ligase ADP-forming subunit beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sucla2"
      },
      {
        "slug": "wars2",
        "symbol": "WARS2",
        "hgnc": "HGNC:12730",
        "name": "tryptophanyl tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wars2"
      },
      {
        "slug": "gne",
        "symbol": "GNE",
        "hgnc": "HGNC:23657",
        "name": "glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gne"
      },
      {
        "slug": "ngly1",
        "symbol": "NGLY1",
        "hgnc": "HGNC:17646",
        "name": "N-glycanase 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ngly1"
      },
      {
        "slug": "letm1",
        "symbol": "LETM1",
        "hgnc": "HGNC:6556",
        "name": "leucine zipper and EF-hand containing transmembrane protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/letm1"
      },
      {
        "slug": "mtrr",
        "symbol": "MTRR",
        "hgnc": "HGNC:7473",
        "name": "5-methyltetrahydrofolate-homocysteine methyltransferase reductase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtrr"
      },
      {
        "slug": "neurod2",
        "symbol": "NEUROD2",
        "hgnc": "HGNC:7763",
        "name": "neuronal differentiation 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/neurod2"
      },
      {
        "slug": "pnkd",
        "symbol": "PNKD",
        "hgnc": "HGNC:9153",
        "name": "PNKD metallo-beta-lactamase domain containing",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pnkd"
      },
      {
        "slug": "prrt2",
        "symbol": "PRRT2",
        "hgnc": "HGNC:30500",
        "name": "proline rich transmembrane protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prrt2"
      },
      {
        "slug": "rragd",
        "symbol": "RRAGD",
        "hgnc": "HGNC:19903",
        "name": "Ras related GTP binding D",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rragd"
      },
      {
        "slug": "scn1a",
        "symbol": "SCN1A",
        "hgnc": "HGNC:10585",
        "name": "sodium voltage-gated channel alpha subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn1a"
      },
      {
        "slug": "slc6a3",
        "symbol": "SLC6A3",
        "hgnc": "HGNC:11049",
        "name": "solute carrier family 6 member 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a3"
      },
      {
        "slug": "slc9a6",
        "symbol": "SLC9A6",
        "hgnc": "HGNC:11079",
        "name": "solute carrier family 9 member A6",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc9a6"
      },
      {
        "slug": "syt1",
        "symbol": "SYT1",
        "hgnc": "HGNC:11509",
        "name": "synaptotagmin 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/syt1"
      },
      {
        "slug": "trappc11",
        "symbol": "TRAPPC11",
        "hgnc": "HGNC:25751",
        "name": "trafficking protein particle complex subunit 11",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/trappc11"
      },
      {
        "slug": "bckdk",
        "symbol": "BCKDK",
        "hgnc": "HGNC:16902",
        "name": "branched chain keto acid dehydrogenase kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bckdk"
      },
      {
        "slug": "camk2b",
        "symbol": "CAMK2B",
        "hgnc": "HGNC:1461",
        "name": "calcium/calmodulin dependent protein kinase II beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/camk2b"
      },
      {
        "slug": "clpb",
        "symbol": "CLPB",
        "hgnc": "HGNC:30664",
        "name": "ClpB family mitochondrial disaggregase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clpb"
      },
      {
        "slug": "gad1",
        "symbol": "GAD1",
        "hgnc": "HGNC:4092",
        "name": "glutamate decarboxylase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gad1"
      },
      {
        "slug": "grin2a",
        "symbol": "GRIN2A",
        "hgnc": "HGNC:4585",
        "name": "glutamate ionotropic receptor NMDA type subunit 2A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grin2a"
      },
      {
        "slug": "hsd17b10",
        "symbol": "HSD17B10",
        "hgnc": "HGNC:4800",
        "name": "hydroxysteroid 17-beta dehydrogenase 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hsd17b10"
      },
      {
        "slug": "iars2",
        "symbol": "IARS2",
        "hgnc": "HGNC:29685",
        "name": "isoleucyl-tRNA synthetase 2, mitochondrial",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/iars2"
      },
      {
        "slug": "iqsec2",
        "symbol": "IQSEC2",
        "hgnc": "HGNC:29059",
        "name": "IQ motif and Sec7 domain ArfGEF 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/iqsec2"
      },
      {
        "slug": "pts",
        "symbol": "PTS",
        "hgnc": "HGNC:9689",
        "name": "6-pyruvoyltetrahydropterin synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pts"
      },
      {
        "slug": "rttn",
        "symbol": "RTTN",
        "hgnc": "HGNC:18654",
        "name": "rotatin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rttn"
      },
      {
        "slug": "suclg1",
        "symbol": "SUCLG1",
        "hgnc": "HGNC:11449",
        "name": "succinate-CoA ligase GDP/ADP-forming subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/suclg1"
      },
      {
        "slug": "thoc2",
        "symbol": "THOC2",
        "hgnc": "HGNC:19073",
        "name": "THO complex subunit 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/thoc2"
      },
      {
        "slug": "vps13a",
        "symbol": "VPS13A",
        "hgnc": "HGNC:1908",
        "name": "vacuolar protein sorting 13 homolog A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps13a"
      },
      {
        "slug": "yme1l1",
        "symbol": "YME1L1",
        "hgnc": "HGNC:12843",
        "name": "YME1 like 1 ATPase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yme1l1"
      },
      {
        "slug": "afg3l2",
        "symbol": "AFG3L2",
        "hgnc": "HGNC:315",
        "name": "AFG3 like matrix AAA peptidase subunit 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/afg3l2"
      },
      {
        "slug": "aldh5a1",
        "symbol": "ALDH5A1",
        "hgnc": "HGNC:408",
        "name": "aldehyde dehydrogenase 5 family member A1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh5a1"
      },
      {
        "slug": "cacna1b",
        "symbol": "CACNA1B",
        "hgnc": "HGNC:1389",
        "name": "calcium voltage-gated channel subunit alpha1 B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1b"
      },
      {
        "slug": "cacna1e",
        "symbol": "CACNA1E",
        "hgnc": "HGNC:1392",
        "name": "calcium voltage-gated channel subunit alpha1 E",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1e"
      },
      {
        "slug": "frrs1l",
        "symbol": "FRRS1L",
        "hgnc": "HGNC:1362",
        "name": "ferric chelate reductase 1 like",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/frrs1l"
      },
      {
        "slug": "gch1",
        "symbol": "GCH1",
        "hgnc": "HGNC:4193",
        "name": "GTP cyclohydrolase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gch1"
      },
      {
        "slug": "gnao1",
        "symbol": "GNAO1",
        "hgnc": "HGNC:4389",
        "name": "G protein subunit alpha o1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnao1"
      },
      {
        "slug": "grin1",
        "symbol": "GRIN1",
        "hgnc": "HGNC:4584",
        "name": "glutamate ionotropic receptor NMDA type subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grin1"
      },
      {
        "slug": "pde10a",
        "symbol": "PDE10A",
        "hgnc": "HGNC:8772",
        "name": "phosphodiesterase 10A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde10a"
      },
      {
        "slug": "pycr2",
        "symbol": "PYCR2",
        "hgnc": "HGNC:30262",
        "name": "pyrroline-5-carboxylate reductase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pycr2"
      },
      {
        "slug": "znf142",
        "symbol": "ZNF142",
        "hgnc": "HGNC:12927",
        "name": "zinc finger protein 142",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf142"
      }
    ]
  }
}