{
  "url": "https://dantelabs.com/traits/hydrocele-testis",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "hydrocele-testis",
    "id": "HP:0000034",
    "name": "Hydrocele testis",
    "definition": "Accumulation of clear fluid in the between the layers of membrane (tunica vaginalis) surrounding the testis.",
    "synonyms": [
      "Testicular hydrocele"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-testis-morphology",
        "name": "Abnormality of the testis",
        "url": "https://dantelabs.com/traits/abnormal-testis-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "congenital-hydrocele",
        "name": "Congenital hydrocele",
        "genes": 1,
        "url": "https://dantelabs.com/traits/congenital-hydrocele"
      }
    ],
    "genes": [
      {
        "slug": "adamts3",
        "symbol": "ADAMTS3",
        "hgnc": "HGNC:219",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamts3"
      },
      {
        "slug": "ciroz",
        "symbol": "CIROZ",
        "hgnc": "HGNC:26730",
        "name": "ciliated left-right organizer protein containing ZP-N domains",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ciroz"
      },
      {
        "slug": "fryl",
        "symbol": "FRYL",
        "hgnc": "HGNC:29127",
        "name": "FRY like transcription coactivator",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fryl"
      },
      {
        "slug": "mecom",
        "symbol": "MECOM",
        "hgnc": "HGNC:3498",
        "name": "MDS1 and EVI1 complex locus",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mecom"
      },
      {
        "slug": "slc25a10",
        "symbol": "SLC25A10",
        "hgnc": "HGNC:10980",
        "name": "solute carrier family 25 member 10",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a10"
      },
      {
        "slug": "sox18",
        "symbol": "SOX18",
        "hgnc": "HGNC:11194",
        "name": "SRY-box transcription factor 18",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/sox18"
      },
      {
        "slug": "angpt2",
        "symbol": "ANGPT2",
        "hgnc": "HGNC:485",
        "name": "angiopoietin 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/angpt2"
      },
      {
        "slug": "dph2",
        "symbol": "DPH2",
        "hgnc": "HGNC:3004",
        "name": "diphthamide biosynthesis 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dph2"
      },
      {
        "slug": "flt4",
        "symbol": "FLT4",
        "hgnc": "HGNC:3767",
        "name": "fms related receptor tyrosine kinase 4",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/flt4"
      },
      {
        "slug": "mdfic",
        "symbol": "MDFIC",
        "hgnc": "HGNC:28870",
        "name": "MyoD family inhibitor domain containing",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mdfic"
      },
      {
        "slug": "pigl",
        "symbol": "PIGL",
        "hgnc": "HGNC:8966",
        "name": "phosphatidylinositol glycan anchor biosynthesis class L",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigl"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "setd1a",
        "symbol": "SETD1A",
        "hgnc": "HGNC:29010",
        "name": "SET domain containing 1A, histone lysine methyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/setd1a"
      },
      {
        "slug": "specc1l",
        "symbol": "SPECC1L",
        "hgnc": "HGNC:29022",
        "name": "sperm antigen with calponin homology and coiled-coil domains 1 like",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/specc1l"
      },
      {
        "slug": "thsd1",
        "symbol": "THSD1",
        "hgnc": "HGNC:17754",
        "name": "thrombospondin type 1 domain containing 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/thsd1"
      },
      {
        "slug": "vegfc",
        "symbol": "VEGFC",
        "hgnc": "HGNC:12682",
        "name": "vascular endothelial growth factor C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vegfc"
      },
      {
        "slug": "adamts15",
        "symbol": "ADAMTS15",
        "hgnc": "HGNC:16305",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 15",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamts15"
      },
      {
        "slug": "crebbp",
        "symbol": "CREBBP",
        "hgnc": "HGNC:2348",
        "name": "CREB binding lysine acetyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crebbp"
      },
      {
        "slug": "edem3",
        "symbol": "EDEM3",
        "hgnc": "HGNC:16787",
        "name": "ER degradation enhancing alpha-mannosidase like protein 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/edem3"
      },
      {
        "slug": "ep300",
        "symbol": "EP300",
        "hgnc": "HGNC:3373",
        "name": "EP300 lysine acetyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ep300"
      },
      {
        "slug": "focad",
        "symbol": "FOCAD",
        "hgnc": "HGNC:23377",
        "name": "focadhesin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/focad"
      },
      {
        "slug": "kmt2d",
        "symbol": "KMT2D",
        "hgnc": "HGNC:7133",
        "name": "lysine methyltransferase 2D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kmt2d"
      },
      {
        "slug": "mogs",
        "symbol": "MOGS",
        "hgnc": "HGNC:24862",
        "name": "mannosyl-oligosaccharide glucosidase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mogs"
      },
      {
        "slug": "naa10",
        "symbol": "NAA10",
        "hgnc": "HGNC:18704",
        "name": "N-alpha-acetyltransferase 10, NatA catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/naa10"
      },
      {
        "slug": "pign",
        "symbol": "PIGN",
        "hgnc": "HGNC:8967",
        "name": "phosphatidylinositol glycan anchor biosynthesis class N",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pign"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "tbx1",
        "symbol": "TBX1",
        "hgnc": "HGNC:11592",
        "name": "T-box transcription factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx1"
      },
      {
        "slug": "zmym2",
        "symbol": "ZMYM2",
        "hgnc": "HGNC:12989",
        "name": "zinc finger MYM-type containing 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmym2"
      },
      {
        "slug": "apc2",
        "symbol": "APC2",
        "hgnc": "HGNC:24036",
        "name": "APC regulator of Wnt signaling pathway 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apc2"
      },
      {
        "slug": "nsd1",
        "symbol": "NSD1",
        "hgnc": "HGNC:14234",
        "name": "nuclear receptor binding SET domain protein 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsd1"
      },
      {
        "slug": "zeb2",
        "symbol": "ZEB2",
        "hgnc": "HGNC:14881",
        "name": "zinc finger E-box binding homeobox 2",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/zeb2"
      },
      {
        "slug": "atad3a",
        "symbol": "ATAD3A",
        "hgnc": "HGNC:25567",
        "name": "ATPase family AAA domain containing 3A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atad3a"
      },
      {
        "slug": "ezh2",
        "symbol": "EZH2",
        "hgnc": "HGNC:3527",
        "name": "enhancer of zeste 2 polycomb repressive complex 2 subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ezh2"
      },
      {
        "slug": "pex11b",
        "symbol": "PEX11B",
        "hgnc": "HGNC:8853",
        "name": "peroxisomal biogenesis factor 11 beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex11b"
      },
      {
        "slug": "piezo1",
        "symbol": "PIEZO1",
        "hgnc": "HGNC:28993",
        "name": "piezo type mechanosensitive ion channel component 1 (Er blood group)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piezo1"
      }
    ]
  }
}