{
  "url": "https://dantelabs.com/traits/global-glomerulosclerosis",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "global-glomerulosclerosis",
    "id": "HP:0004737",
    "name": "Global glomerulosclerosis",
    "definition": "Obliteration of the glomerular capillary lumen by increased collagenous matrix, with or without hyalinosis or foam cells. Sclerosis involves 100% of the glomerular tuft. Relative to other patent glomeruli in the sample, glomerular size is preserved, or increased/decreased by no more than 50%.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "glomerular-sclerosis",
        "name": "Glomerular sclerosis",
        "url": "https://dantelabs.com/traits/glomerular-sclerosis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "pskh1",
        "symbol": "PSKH1",
        "hgnc": "HGNC:9529",
        "name": "protein serine kinase H1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pskh1"
      },
      {
        "slug": "wdr19",
        "symbol": "WDR19",
        "hgnc": "HGNC:18340",
        "name": "WD repeat domain 19",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/wdr19"
      },
      {
        "slug": "naa10",
        "symbol": "NAA10",
        "hgnc": "HGNC:18704",
        "name": "N-alpha-acetyltransferase 10, NatA catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/naa10"
      },
      {
        "slug": "bsnd",
        "symbol": "BSND",
        "hgnc": "HGNC:16512",
        "name": "barttin CLCNK type accessory subunit beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bsnd"
      }
    ]
  }
}