{
  "url": "https://dantelabs.com/traits/flared-metaphysis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "flared-metaphysis",
    "id": "HP:0003015",
    "name": "Flared wide portion of long bone",
    "label": "Flared metaphysis",
    "definition": "The presence of a splayed (i.e.,flared) metaphyseal segment of one or more long bones.",
    "synonyms": [
      "Flared, widened metaphyses",
      "marked metaphyseal flaring of long bones",
      "Metaphyseal flaring",
      "Metaphyseal flaring of long bones",
      "Metaphyseal splaying",
      "Metaphyses flared",
      "Splayed metaphyses"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "metaphyseal-widening",
        "name": "Broad wide portion of long bone",
        "url": "https://dantelabs.com/traits/metaphyseal-widening"
      }
    ],
    "narrower": [
      {
        "slug": "flared-lower-limb-metaphysis",
        "name": "Flared lower limb metaphysis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/flared-lower-limb-metaphysis"
      },
      {
        "slug": "flared-upper-limb-metaphysis",
        "name": "Flared wide portion of the upper limb bone",
        "genes": 0,
        "url": "https://dantelabs.com/traits/flared-upper-limb-metaphysis"
      }
    ],
    "genes": [
      {
        "slug": "ankh",
        "symbol": "ANKH",
        "hgnc": "HGNC:15492",
        "name": "ANKH inorganic pyrophosphate transport regulator",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ankh"
      },
      {
        "slug": "axin1",
        "symbol": "AXIN1",
        "hgnc": "HGNC:903",
        "name": "axin 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/axin1"
      },
      {
        "slug": "b3galt6",
        "symbol": "B3GALT6",
        "hgnc": "HGNC:17978",
        "name": "beta-1,3-galactosyltransferase 6",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/b3galt6"
      },
      {
        "slug": "cog4",
        "symbol": "COG4",
        "hgnc": "HGNC:18620",
        "name": "component of oligomeric golgi complex 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cog4"
      },
      {
        "slug": "cyp3a4",
        "symbol": "CYP3A4",
        "hgnc": "HGNC:2637",
        "name": "cytochrome P450 family 3 subfamily A member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp3a4"
      },
      {
        "slug": "dna2",
        "symbol": "DNA2",
        "hgnc": "HGNC:2939",
        "name": "DNA replication helicase/nuclease 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dna2"
      },
      {
        "slug": "eed",
        "symbol": "EED",
        "hgnc": "HGNC:3188",
        "name": "embryonic ectoderm development",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eed"
      },
      {
        "slug": "ercc1",
        "symbol": "ERCC1",
        "hgnc": "HGNC:3433",
        "name": "ERCC excision repair 1, endonuclease non-catalytic subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc1"
      },
      {
        "slug": "fgfr3",
        "symbol": "FGFR3",
        "hgnc": "HGNC:3690",
        "name": "fibroblast growth factor receptor 3",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/fgfr3"
      },
      {
        "slug": "iars2",
        "symbol": "IARS2",
        "hgnc": "HGNC:29685",
        "name": "isoleucyl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/iars2"
      },
      {
        "slug": "lbr",
        "symbol": "LBR",
        "hgnc": "HGNC:6518",
        "name": "lamin B receptor",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lbr"
      },
      {
        "slug": "pcyt1a",
        "symbol": "PCYT1A",
        "hgnc": "HGNC:8754",
        "name": "phosphate cytidylyltransferase 1A, choline",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pcyt1a"
      },
      {
        "slug": "rmrp",
        "symbol": "RMRP",
        "hgnc": "HGNC:10031",
        "name": "RNA component of mitochondrial RNA processing endoribonuclease",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rmrp"
      },
      {
        "slug": "trpv4",
        "symbol": "TRPV4",
        "hgnc": "HGNC:18083",
        "name": "transient receptor potential cation channel subfamily V member 4",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/trpv4"
      },
      {
        "slug": "col2a1",
        "symbol": "COL2A1",
        "hgnc": "HGNC:2200",
        "name": "collagen type II alpha 1 chain",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col2a1"
      },
      {
        "slug": "map3k7",
        "symbol": "MAP3K7",
        "hgnc": "HGNC:6859",
        "name": "mitogen-activated protein kinase kinase kinase 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map3k7"
      },
      {
        "slug": "pth1r",
        "symbol": "PTH1R",
        "hgnc": "HGNC:9608",
        "name": "parathyroid hormone 1 receptor",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pth1r"
      },
      {
        "slug": "b3gat3",
        "symbol": "B3GAT3",
        "hgnc": "HGNC:923",
        "name": "beta-1,3-glucuronyltransferase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b3gat3"
      },
      {
        "slug": "b4galt7",
        "symbol": "B4GALT7",
        "hgnc": "HGNC:930",
        "name": "beta-1,4-galactosyltransferase 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b4galt7"
      },
      {
        "slug": "chst3",
        "symbol": "CHST3",
        "hgnc": "HGNC:1971",
        "name": "carbohydrate sulfotransferase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chst3"
      },
      {
        "slug": "col10a1",
        "symbol": "COL10A1",
        "hgnc": "HGNC:2185",
        "name": "collagen type X alpha 1 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col10a1"
      },
      {
        "slug": "ddrgk1",
        "symbol": "DDRGK1",
        "hgnc": "HGNC:16110",
        "name": "DDRGK domain containing 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ddrgk1"
      },
      {
        "slug": "gsc",
        "symbol": "GSC",
        "hgnc": "HGNC:4612",
        "name": "goosecoid homeobox",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gsc"
      },
      {
        "slug": "mmp13",
        "symbol": "MMP13",
        "hgnc": "HGNC:7159",
        "name": "matrix metallopeptidase 13",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mmp13"
      },
      {
        "slug": "nek1",
        "symbol": "NEK1",
        "hgnc": "HGNC:7744",
        "name": "NIMA related kinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek1"
      },
      {
        "slug": "prkg2",
        "symbol": "PRKG2",
        "hgnc": "HGNC:9416",
        "name": "protein kinase cGMP-dependent 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkg2"
      },
      {
        "slug": "slc39a13",
        "symbol": "SLC39A13",
        "hgnc": "HGNC:20859",
        "name": "solute carrier family 39 member 13",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc39a13"
      },
      {
        "slug": "xylt1",
        "symbol": "XYLT1",
        "hgnc": "HGNC:15516",
        "name": "xylosyltransferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xylt1"
      },
      {
        "slug": "alg9",
        "symbol": "ALG9",
        "hgnc": "HGNC:15672",
        "name": "ALG9 alpha-1,2-mannosyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg9"
      },
      {
        "slug": "comp",
        "symbol": "COMP",
        "hgnc": "HGNC:2227",
        "name": "cartilage oligomeric matrix protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/comp"
      },
      {
        "slug": "fig4",
        "symbol": "FIG4",
        "hgnc": "HGNC:16873",
        "name": "FIG4 phosphoinositide 5-phosphatase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fig4"
      },
      {
        "slug": "tonsl",
        "symbol": "TONSL",
        "hgnc": "HGNC:7801",
        "name": "tonsoku like, DNA repair protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tonsl"
      },
      {
        "slug": "vac14",
        "symbol": "VAC14",
        "hgnc": "HGNC:25507",
        "name": "VAC14 component of PIKFYVE complex",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vac14"
      },
      {
        "slug": "ccn2",
        "symbol": "CCN2",
        "hgnc": "HGNC:2500",
        "name": "cellular communication network factor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccn2"
      },
      {
        "slug": "col11a2",
        "symbol": "COL11A2",
        "hgnc": "HGNC:2187",
        "name": "collagen type XI alpha 2 chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col11a2"
      },
      {
        "slug": "ddr2",
        "symbol": "DDR2",
        "hgnc": "HGNC:2731",
        "name": "discoidin domain receptor tyrosine kinase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddr2"
      },
      {
        "slug": "fam111a",
        "symbol": "FAM111A",
        "hgnc": "HGNC:24725",
        "name": "FAM111 trypsin like peptidase A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fam111a"
      },
      {
        "slug": "flna",
        "symbol": "FLNA",
        "hgnc": "HGNC:3754",
        "name": "filamin A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flna"
      },
      {
        "slug": "gja1",
        "symbol": "GJA1",
        "hgnc": "HGNC:4274",
        "name": "gap junction protein alpha 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja1"
      },
      {
        "slug": "kif22",
        "symbol": "KIF22",
        "hgnc": "HGNC:6391",
        "name": "kinesin family member 22",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif22"
      },
      {
        "slug": "lifr",
        "symbol": "LIFR",
        "hgnc": "HGNC:6597",
        "name": "LIF receptor subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lifr"
      },
      {
        "slug": "nans",
        "symbol": "NANS",
        "hgnc": "HGNC:19237",
        "name": "N-acetylneuraminate synthase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nans"
      },
      {
        "slug": "npr2",
        "symbol": "NPR2",
        "hgnc": "HGNC:7944",
        "name": "natriuretic peptide receptor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npr2"
      },
      {
        "slug": "ostm1",
        "symbol": "OSTM1",
        "hgnc": "HGNC:21652",
        "name": "osteoclastogenesis associated transmembrane protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ostm1"
      },
      {
        "slug": "pcnt",
        "symbol": "PCNT",
        "hgnc": "HGNC:16068",
        "name": "pericentrin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcnt"
      },
      {
        "slug": "pex7",
        "symbol": "PEX7",
        "hgnc": "HGNC:8860",
        "name": "peroxisomal biogenesis factor 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex7"
      },
      {
        "slug": "ptdss1",
        "symbol": "PTDSS1",
        "hgnc": "HGNC:9587",
        "name": "phosphatidylserine synthase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptdss1"
      },
      {
        "slug": "runx2",
        "symbol": "RUNX2",
        "hgnc": "HGNC:10472",
        "name": "RUNX family transcription factor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/runx2"
      },
      {
        "slug": "sh3pxd2b",
        "symbol": "SH3PXD2B",
        "hgnc": "HGNC:29242",
        "name": "SH3 and PX domains 2B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sh3pxd2b"
      },
      {
        "slug": "tapt1",
        "symbol": "TAPT1",
        "hgnc": "HGNC:26887",
        "name": "transmembrane anterior posterior transformation 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tapt1"
      },
      {
        "slug": "tcirg1",
        "symbol": "TCIRG1",
        "hgnc": "HGNC:11647",
        "name": "T cell immune regulator 1, ATPase H+ transporting V0 subunit a3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcirg1"
      }
    ]
  }
}