{
  "url": "https://dantelabs.com/traits/elevated-circulating-d-dimer-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "elevated-circulating-d-dimer-concentration",
    "id": "HP:0033106",
    "name": "Elevated circulating D-dimer concentration",
    "definition": "An increased concentration of D-dimers, a marker of fibrin degradation, in the blood circulation.",
    "synonyms": [
      "Elevated D-dimers",
      "Elevated fibrin degradation fragment concentration"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-fibrinolysis",
        "name": "Abnormality of fibrinolysis",
        "url": "https://dantelabs.com/traits/abnormality-of-fibrinolysis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "psmb9",
        "symbol": "PSMB9",
        "hgnc": "HGNC:9546",
        "name": "proteasome 20S subunit beta 9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmb9"
      },
      {
        "slug": "stat2",
        "symbol": "STAT2",
        "hgnc": "HGNC:11363",
        "name": "signal transducer and activator of transcription 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat2"
      },
      {
        "slug": "gna14",
        "symbol": "GNA14",
        "hgnc": "HGNC:4382",
        "name": "G protein subunit alpha 14",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gna14"
      },
      {
        "slug": "hla-dqb1",
        "symbol": "HLA-DQB1",
        "hgnc": "HGNC:4944",
        "name": "major histocompatibility complex, class II, DQ beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-dqb1"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "hmox1",
        "symbol": "HMOX1",
        "hgnc": "HGNC:5013",
        "name": "heme oxygenase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmox1"
      }
    ]
  }
}