{
  "url": "https://dantelabs.com/traits/ectopic-ossification",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "ectopic-ossification",
    "id": "HP:0011986",
    "name": "Ectopic ossification",
    "definition": "Formation of abnormal, extraskeletal bony tissue, i.e., the presence of bone in soft tissue where bone normally does not exist.",
    "synonyms": [
      "Ectopic bone formation",
      "Heterotopic ossification"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-bone-ossification",
        "name": "Abnormal bone maturation",
        "url": "https://dantelabs.com/traits/abnormal-bone-ossification"
      }
    ],
    "narrower": [
      {
        "slug": "ectopic-ossification-in-muscle-tissue",
        "name": "Calcification of muscle tissue",
        "genes": 2,
        "url": "https://dantelabs.com/traits/ectopic-ossification-in-muscle-tissue"
      },
      {
        "slug": "ectopic-ossification-in-ligament-tissue",
        "name": "Ectopic ossification in ligament tissue",
        "genes": 1,
        "url": "https://dantelabs.com/traits/ectopic-ossification-in-ligament-tissue"
      },
      {
        "slug": "ectopic-ossification-in-tendon-tissue",
        "name": "Ectopic ossification in tendon tissue",
        "genes": 1,
        "url": "https://dantelabs.com/traits/ectopic-ossification-in-tendon-tissue"
      },
      {
        "slug": "subcutaneous-ossification",
        "name": "Subcutaneous ossification",
        "genes": 1,
        "url": "https://dantelabs.com/traits/subcutaneous-ossification"
      }
    ],
    "genes": [
      {
        "slug": "acvr1",
        "symbol": "ACVR1",
        "hgnc": "HGNC:171",
        "name": "activin A receptor type 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acvr1"
      },
      {
        "slug": "gnas",
        "symbol": "GNAS",
        "hgnc": "HGNC:4392",
        "name": "GNAS complex locus",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/gnas"
      },
      {
        "slug": "lbr",
        "symbol": "LBR",
        "hgnc": "HGNC:6518",
        "name": "lamin B receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lbr"
      },
      {
        "slug": "nt5e",
        "symbol": "NT5E",
        "hgnc": "HGNC:8021",
        "name": "5'-nucleotidase ecto",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nt5e"
      }
    ]
  }
}