{
  "url": "https://dantelabs.com/traits/colitis",
  "trait": {
    "bundleId": "2026.10.18-e609d43e",
    "release": "2026-09-01",
    "slug": "colitis",
    "id": "HP:0002583",
    "name": "Colitis",
    "definition": "Colitis refers to an inflammation of the colon and is often used to describe an inflammation of the large intestine (colon, cecum and rectum). Colitides may be acute and self-limited or chronic, and broadly fit into the category of digestive diseases.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "inflammation-of-the-large-intestine",
        "name": "Inflammation of the large intestine",
        "url": "https://dantelabs.com/traits/inflammation-of-the-large-intestine"
      }
    ],
    "narrower": [
      {
        "slug": "enterocolitis",
        "name": "Enterocolitis",
        "genes": 28,
        "url": "https://dantelabs.com/traits/enterocolitis"
      },
      {
        "slug": "pancolitis",
        "name": "Pancolitis",
        "genes": 5,
        "url": "https://dantelabs.com/traits/pancolitis"
      },
      {
        "slug": "focal-active-colitis",
        "name": "Focal active colitis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/focal-active-colitis"
      },
      {
        "slug": "chronic-colitis",
        "name": "Chronic colitis",
        "genes": 0,
        "url": "https://dantelabs.com/traits/chronic-colitis"
      },
      {
        "slug": "unusual-infectious-colitis",
        "name": "Unusual infectious colitis",
        "genes": 0,
        "url": "https://dantelabs.com/traits/unusual-infectious-colitis"
      }
    ],
    "genes": [
      {
        "slug": "bcl10",
        "symbol": "BCL10",
        "hgnc": "HGNC:989",
        "name": "BCL10 immune signaling adaptor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcl10"
      },
      {
        "slug": "il10ra",
        "symbol": "IL10RA",
        "hgnc": "HGNC:5964",
        "name": "interleukin 10 receptor subunit alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il10ra"
      },
      {
        "slug": "itgav",
        "symbol": "ITGAV",
        "hgnc": "HGNC:6150",
        "name": "integrin subunit alpha V",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgav"
      },
      {
        "slug": "lyn",
        "symbol": "LYN",
        "hgnc": "HGNC:6735",
        "name": "LYN proto-oncogene, Src family tyrosine kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lyn"
      },
      {
        "slug": "ncf4",
        "symbol": "NCF4",
        "hgnc": "HGNC:7662",
        "name": "neutrophil cytosolic factor 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ncf4"
      },
      {
        "slug": "pik3cd",
        "symbol": "PIK3CD",
        "hgnc": "HGNC:8977",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3cd"
      },
      {
        "slug": "pik3cg",
        "symbol": "PIK3CG",
        "hgnc": "HGNC:8978",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3cg"
      },
      {
        "slug": "pstpip1",
        "symbol": "PSTPIP1",
        "hgnc": "HGNC:9580",
        "name": "proline-serine-threonine phosphatase interacting protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pstpip1"
      },
      {
        "slug": "skic2",
        "symbol": "SKIC2",
        "hgnc": "HGNC:10898",
        "name": "SKI2 subunit of superkiller complex",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/skic2"
      },
      {
        "slug": "stxbp2",
        "symbol": "STXBP2",
        "hgnc": "HGNC:11445",
        "name": "syntaxin binding protein 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/stxbp2"
      },
      {
        "slug": "elf4",
        "symbol": "ELF4",
        "hgnc": "HGNC:3319",
        "name": "E74 like ETS transcription factor 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elf4"
      },
      {
        "slug": "fermt1",
        "symbol": "FERMT1",
        "hgnc": "HGNC:15889",
        "name": "FERM domain containing kindlin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fermt1"
      },
      {
        "slug": "pola1",
        "symbol": "POLA1",
        "hgnc": "HGNC:9173",
        "name": "DNA polymerase alpha 1, catalytic subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pola1"
      },
      {
        "slug": "sharpin",
        "symbol": "SHARPIN",
        "hgnc": "HGNC:25321",
        "name": "SHANK associated RH domain interactor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sharpin"
      },
      {
        "slug": "syk",
        "symbol": "SYK",
        "hgnc": "HGNC:11491",
        "name": "spleen associated tyrosine kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/syk"
      },
      {
        "slug": "zap70",
        "symbol": "ZAP70",
        "hgnc": "HGNC:12858",
        "name": "zeta chain of T cell receptor associated protein kinase 70",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/zap70"
      },
      {
        "slug": "carmil2",
        "symbol": "CARMIL2",
        "hgnc": "HGNC:27089",
        "name": "capping protein regulator and myosin 1 linker 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/carmil2"
      },
      {
        "slug": "fcho1",
        "symbol": "FCHO1",
        "hgnc": "HGNC:29002",
        "name": "FCH and mu domain containing endocytic adaptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fcho1"
      },
      {
        "slug": "gpihbp1",
        "symbol": "GPIHBP1",
        "hgnc": "HGNC:24945",
        "name": "glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpihbp1"
      },
      {
        "slug": "irf4",
        "symbol": "IRF4",
        "hgnc": "HGNC:6119",
        "name": "interferon regulatory factor 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf4"
      },
      {
        "slug": "lrba",
        "symbol": "LRBA",
        "hgnc": "HGNC:1742",
        "name": "LPS responsive beige-like anchor protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrba"
      },
      {
        "slug": "prf1",
        "symbol": "PRF1",
        "hgnc": "HGNC:9360",
        "name": "perforin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prf1"
      },
      {
        "slug": "rtel1",
        "symbol": "RTEL1",
        "hgnc": "HGNC:15888",
        "name": "regulator of telomere elongation helicase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rtel1"
      },
      {
        "slug": "skic3",
        "symbol": "SKIC3",
        "hgnc": "HGNC:23639",
        "name": "SKI3 subunit of superkiller complex",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/skic3"
      },
      {
        "slug": "stx11",
        "symbol": "STX11",
        "hgnc": "HGNC:11429",
        "name": "syntaxin 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stx11"
      },
      {
        "slug": "tnfaip3",
        "symbol": "TNFAIP3",
        "hgnc": "HGNC:11896",
        "name": "TNF alpha induced protein 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfaip3"
      },
      {
        "slug": "unc13d",
        "symbol": "UNC13D",
        "hgnc": "HGNC:23147",
        "name": "unc-13 homolog D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc13d"
      },
      {
        "slug": "xiap",
        "symbol": "XIAP",
        "hgnc": "HGNC:592",
        "name": "X-linked inhibitor of apoptosis",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/xiap"
      },
      {
        "slug": "casp10",
        "symbol": "CASP10",
        "hgnc": "HGNC:1500",
        "name": "caspase 10",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/casp10"
      },
      {
        "slug": "fas",
        "symbol": "FAS",
        "hgnc": "HGNC:11920",
        "name": "Fas cell surface death receptor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fas"
      },
      {
        "slug": "faslg",
        "symbol": "FASLG",
        "hgnc": "HGNC:11936",
        "name": "Fas ligand",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/faslg"
      },
      {
        "slug": "foxp3",
        "symbol": "FOXP3",
        "hgnc": "HGNC:6106",
        "name": "forkhead box P3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxp3"
      },
      {
        "slug": "bach2",
        "symbol": "BACH2",
        "hgnc": "HGNC:14078",
        "name": "BACH transcriptional regulator 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bach2"
      },
      {
        "slug": "ciita",
        "symbol": "CIITA",
        "hgnc": "HGNC:7067",
        "name": "class II major histocompatibility complex transactivator",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ciita"
      },
      {
        "slug": "hps1",
        "symbol": "HPS1",
        "hgnc": "HGNC:5163",
        "name": "HPS1 biogenesis of lysosomal organelles complex 3 subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hps1"
      },
      {
        "slug": "ivns1abp",
        "symbol": "IVNS1ABP",
        "hgnc": "HGNC:16951",
        "name": "influenza virus NS1A binding protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ivns1abp"
      }
    ]
  }
}