{
  "url": "https://dantelabs.com/traits/angioedema",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "angioedema",
    "id": "HP:0100665",
    "name": "Angioedema",
    "definition": "Rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues of the skin of the face, normally around the mouth, and the mucosa of the mouth and/or throat, as well as the tongue during a period of minutes to several hours. The swelling can also occur elsewhere, typically in the hands. Angioedema is similar to urticaria, but the swelling is subcutaneous rather than on the epidermis.",
    "synonyms": [
      "Angioneurotic edema",
      "Angioneurotic oedema",
      "Angiooedema",
      "Quincke edema",
      "Quincke oedema"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      },
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "edema",
        "name": "Fluid retention",
        "url": "https://dantelabs.com/traits/edema"
      },
      {
        "slug": "vascular-skin-abnormality",
        "name": "Vascular skin abnormality",
        "url": "https://dantelabs.com/traits/vascular-skin-abnormality"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "angpt1",
        "symbol": "ANGPT1",
        "hgnc": "HGNC:484",
        "name": "angiopoietin 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/angpt1"
      },
      {
        "slug": "kng1",
        "symbol": "KNG1",
        "hgnc": "HGNC:6383",
        "name": "kininogen 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kng1"
      },
      {
        "slug": "myof",
        "symbol": "MYOF",
        "hgnc": "HGNC:3656",
        "name": "myoferlin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myof"
      },
      {
        "slug": "xpnpep2",
        "symbol": "XPNPEP2",
        "hgnc": "HGNC:12823",
        "name": "X-prolyl aminopeptidase 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/xpnpep2"
      },
      {
        "slug": "dnase1l3",
        "symbol": "DNASE1L3",
        "hgnc": "HGNC:2959",
        "name": "deoxyribonuclease 1L3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnase1l3"
      },
      {
        "slug": "plcg2",
        "symbol": "PLCG2",
        "hgnc": "HGNC:9066",
        "name": "phospholipase C gamma 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plcg2"
      },
      {
        "slug": "spink5",
        "symbol": "SPINK5",
        "hgnc": "HGNC:15464",
        "name": "serine peptidase inhibitor Kazal type 5",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/spink5"
      },
      {
        "slug": "kit",
        "symbol": "KIT",
        "hgnc": "HGNC:6342",
        "name": "KIT proto-oncogene, receptor tyrosine kinase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kit"
      },
      {
        "slug": "cpn1",
        "symbol": "CPN1",
        "hgnc": "HGNC:2312",
        "name": "carboxypeptidase N subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cpn1"
      },
      {
        "slug": "f12",
        "symbol": "F12",
        "hgnc": "HGNC:3530",
        "name": "coagulation factor XII",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f12"
      },
      {
        "slug": "hs3st6",
        "symbol": "HS3ST6",
        "hgnc": "HGNC:14178",
        "name": "heparan sulfate-glucosamine 3-sulfotransferase 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hs3st6"
      },
      {
        "slug": "plg",
        "symbol": "PLG",
        "hgnc": "HGNC:9071",
        "name": "plasminogen",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plg"
      },
      {
        "slug": "serping1",
        "symbol": "SERPING1",
        "hgnc": "HGNC:1228",
        "name": "serpin family G member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serping1"
      }
    ]
  }
}