{
  "url": "https://dantelabs.com/traits/acidosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "acidosis",
    "id": "HP:0001941",
    "name": "Acidosis",
    "definition": "Abnormal acid accumulation or depletion of base.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-acid-base-homeostasis",
        "name": "Abnormality of acid-base homeostasis",
        "url": "https://dantelabs.com/traits/abnormality-of-acid-base-homeostasis"
      }
    ],
    "narrower": [
      {
        "slug": "increased-circulating-lactate-concentration",
        "name": "Higher than normal levels of lactate in blood",
        "genes": 234,
        "url": "https://dantelabs.com/traits/increased-circulating-lactate-concentration"
      },
      {
        "slug": "lactic-acidosis",
        "name": "Increased lactate in body",
        "genes": 202,
        "url": "https://dantelabs.com/traits/lactic-acidosis"
      },
      {
        "slug": "metabolic-acidosis",
        "name": "Metabolic acidosis",
        "genes": 136,
        "url": "https://dantelabs.com/traits/metabolic-acidosis"
      },
      {
        "slug": "ketoacidosis",
        "name": "Ketoacidosis",
        "genes": 21,
        "url": "https://dantelabs.com/traits/ketoacidosis"
      },
      {
        "slug": "respiratory-acidosis",
        "name": "Respiratory acidosis",
        "genes": 2,
        "url": "https://dantelabs.com/traits/respiratory-acidosis"
      },
      {
        "slug": "chronic-acidosis",
        "name": "Chronic acidosis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/chronic-acidosis"
      },
      {
        "slug": "hyperchloremic-acidosis",
        "name": "Hyperchloremic acidosis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/hyperchloremic-acidosis"
      }
    ],
    "genes": [
      {
        "slug": "mrm2",
        "symbol": "MRM2",
        "hgnc": "HGNC:16352",
        "name": "mitochondrial rRNA methyltransferase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrm2"
      },
      {
        "slug": "ndufa2",
        "symbol": "NDUFA2",
        "hgnc": "HGNC:7685",
        "name": "NADH:ubiquinone oxidoreductase subunit A2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufa2"
      },
      {
        "slug": "nfu1",
        "symbol": "NFU1",
        "hgnc": "HGNC:16287",
        "name": "NFU1 iron-sulfur cluster scaffold",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfu1"
      },
      {
        "slug": "acat1",
        "symbol": "ACAT1",
        "hgnc": "HGNC:93",
        "name": "acetyl-CoA acetyltransferase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acat1"
      },
      {
        "slug": "ctns",
        "symbol": "CTNS",
        "hgnc": "HGNC:2518",
        "name": "cystinosin, lysosomal cystine transporter",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctns"
      },
      {
        "slug": "cyp11a1",
        "symbol": "CYP11A1",
        "hgnc": "HGNC:2590",
        "name": "cytochrome P450 family 11 subfamily A member 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cyp11a1"
      },
      {
        "slug": "kcnj16",
        "symbol": "KCNJ16",
        "hgnc": "HGNC:6262",
        "name": "potassium inwardly rectifying channel subfamily J member 16",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj16"
      },
      {
        "slug": "cldn16",
        "symbol": "CLDN16",
        "hgnc": "HGNC:2037",
        "name": "claudin 16",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cldn16"
      },
      {
        "slug": "acsf3",
        "symbol": "ACSF3",
        "hgnc": "HGNC:27288",
        "name": "acyl-CoA synthetase family member 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acsf3"
      },
      {
        "slug": "epg5",
        "symbol": "EPG5",
        "hgnc": "HGNC:29331",
        "name": "ectopic P-granules 5 autophagy tethering factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epg5"
      },
      {
        "slug": "etfa",
        "symbol": "ETFA",
        "hgnc": "HGNC:3481",
        "name": "electron transfer flavoprotein subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/etfa"
      },
      {
        "slug": "etfb",
        "symbol": "ETFB",
        "hgnc": "HGNC:3482",
        "name": "electron transfer flavoprotein subunit beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/etfb"
      },
      {
        "slug": "etfdh",
        "symbol": "ETFDH",
        "hgnc": "HGNC:3483",
        "name": "electron transfer flavoprotein dehydrogenase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/etfdh"
      },
      {
        "slug": "slc2a2",
        "symbol": "SLC2A2",
        "hgnc": "HGNC:11006",
        "name": "solute carrier family 2 member 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc2a2"
      }
    ]
  }
}