{
  "url": "https://dantelabs.com/traits/abnormal-circulating-potassium-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-potassium-concentration",
    "id": "HP:0011042",
    "name": "Abnormal circulating potassium concentration",
    "definition": "Any deviation from the normal concentration of potassium(1+) in the blood circulation.",
    "synonyms": [
      "Abnormal blood K concentration",
      "Abnormal blood potassium concentration",
      "Abnormal potassium(1+) level",
      "Abnormality of potassium homeostasis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-monovalent-inorganic-cation-concentration",
        "name": "Abnormal circulating monovalent inorganic cation concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-monovalent-inorganic-cation-concentration"
      }
    ],
    "narrower": [
      {
        "slug": "hypokalemia",
        "name": "Low blood potassium levels",
        "genes": 62,
        "url": "https://dantelabs.com/traits/hypokalemia"
      },
      {
        "slug": "hyperkalemia",
        "name": "Increased circulating potassium concentration",
        "genes": 42,
        "url": "https://dantelabs.com/traits/hyperkalemia"
      },
      {
        "slug": "hyperkalemia-while-symptomatic",
        "name": "Hyperkalemia while symptomatic",
        "genes": 1,
        "url": "https://dantelabs.com/traits/hyperkalemia-while-symptomatic"
      },
      {
        "slug": "pseudohyperkalemia",
        "name": "Pseudohyperkalemia",
        "genes": 1,
        "url": "https://dantelabs.com/traits/pseudohyperkalemia"
      }
    ],
    "genes": [
      {
        "slug": "kcnn4",
        "symbol": "KCNN4",
        "hgnc": "HGNC:6293",
        "name": "potassium calcium-activated channel subfamily N member 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnn4"
      },
      {
        "slug": "piezo1",
        "symbol": "PIEZO1",
        "hgnc": "HGNC:28993",
        "name": "piezo type mechanosensitive ion channel component 1 (Er blood group)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piezo1"
      },
      {
        "slug": "slc4a1",
        "symbol": "SLC4A1",
        "hgnc": "HGNC:11027",
        "name": "solute carrier family 4 member 1 (Diego blood group)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc4a1"
      },
      {
        "slug": "scn4a",
        "symbol": "SCN4A",
        "hgnc": "HGNC:10591",
        "name": "sodium voltage-gated channel alpha subunit 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn4a"
      }
    ]
  }
}