{
  "url": "https://dantelabs.com/traits/abnormal-atrioventricular-conduction",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-atrioventricular-conduction",
    "id": "HP:0005150",
    "name": "Abnormal atrioventricular conduction",
    "definition": "An impairment of the electrical continuity between the atria and ventricles.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "cardiac-conduction-abnormality",
        "name": "Cardiac conduction abnormality",
        "url": "https://dantelabs.com/traits/cardiac-conduction-abnormality"
      }
    ],
    "narrower": [
      {
        "slug": "atrioventricular-block",
        "name": "Interruption of electrical communication between upper and lower chambers of heart",
        "genes": 41,
        "url": "https://dantelabs.com/traits/atrioventricular-block"
      },
      {
        "slug": "atrioventricular-dissociation",
        "name": "Atrioventricular dissociation",
        "genes": 1,
        "url": "https://dantelabs.com/traits/atrioventricular-dissociation"
      }
    ],
    "genes": [
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "ttr",
        "symbol": "TTR",
        "hgnc": "HGNC:12405",
        "name": "transthyretin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttr"
      },
      {
        "slug": "rnaseh1",
        "symbol": "RNASEH1",
        "hgnc": "HGNC:18466",
        "name": "ribonuclease H1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnaseh1"
      },
      {
        "slug": "rrm2b",
        "symbol": "RRM2B",
        "hgnc": "HGNC:17296",
        "name": "ribonucleotide reductase regulatory TP53 inducible subunit M2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm2b"
      },
      {
        "slug": "sdha",
        "symbol": "SDHA",
        "hgnc": "HGNC:10680",
        "name": "succinate dehydrogenase complex flavoprotein subunit A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdha"
      },
      {
        "slug": "sdhaf1",
        "symbol": "SDHAF1",
        "hgnc": "HGNC:33867",
        "name": "succinate dehydrogenase complex assembly factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhaf1"
      },
      {
        "slug": "sdhb",
        "symbol": "SDHB",
        "hgnc": "HGNC:10681",
        "name": "succinate dehydrogenase complex iron sulfur subunit B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhb"
      },
      {
        "slug": "sdhd",
        "symbol": "SDHD",
        "hgnc": "HGNC:10683",
        "name": "succinate dehydrogenase complex subunit D",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhd"
      }
    ]
  }
}