{
  "url": "https://dantelabs.com/tr/genes/tceal1",
  "gene": {
    "slug": "tceal1",
    "symbol": "TCEAL1",
    "name": "transcription elongation factor A like 1",
    "hgnc": "HGNC:11616",
    "summary": null,
    "location": "Xq22.2",
    "locusType": "gene with protein product",
    "aliases": [
      "p21",
      "pp21",
      "SIIR",
      "P21",
      "WEX9"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000172465",
    "entrezId": 9338,
    "omim": [
      "300237"
    ],
    "uniprot": [
      "Q15170"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "X",
      "start": 103628975,
      "end": 103630953,
      "strand": "+",
      "ensemblTranscript": "ENST00000372625.8",
      "refseqTranscript": "NM_004780.3",
      "ensemblProtein": "ENSP00000361708.3",
      "refseqProtein": "NP_004771.2",
      "exons": [
        {
          "start": 103628975,
          "end": 103629025
        },
        {
          "start": 103629494,
          "end": 103629573
        },
        {
          "start": 103629885,
          "end": 103630953
        }
      ],
      "cds": {
        "start": 103629917,
        "end": 103630396
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "X",
      "start": 102883632,
      "end": 102885881,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 103129964,
      "end": 104129963,
      "genes": [
        {
          "symbol": "BEX4",
          "ensemblId": "ENSG00000102409",
          "biotype": "protein_coding",
          "start": 103215068,
          "end": 103217931,
          "strand": "+",
          "slug": "bex4"
        },
        {
          "symbol": "TCEAL8",
          "ensemblId": "ENSG00000180964",
          "biotype": "protein_coding",
          "start": 103249397,
          "end": 103255207,
          "strand": "-",
          "slug": "tceal8"
        },
        {
          "symbol": "TCEAL5",
          "ensemblId": "ENSG00000204065",
          "biotype": "protein_coding",
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          "end": 103277004,
          "strand": "-",
          "slug": "tceal5"
        },
        {
          "symbol": "BEX2",
          "ensemblId": "ENSG00000133134",
          "biotype": "protein_coding",
          "start": 103309345,
          "end": 103311298,
          "strand": "-",
          "slug": "bex2"
        },
        {
          "symbol": "TCEAL7",
          "ensemblId": "ENSG00000182916",
          "biotype": "protein_coding",
          "start": 103310446,
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          "strand": "+",
          "slug": "tceal7"
        },
        {
          "symbol": "TCEAL9",
          "ensemblId": "ENSG00000185222",
          "biotype": "protein_coding",
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          "end": 103358696,
          "strand": "+",
          "slug": "tceal9"
        },
        {
          "symbol": "BEX3",
          "ensemblId": "ENSG00000166681",
          "biotype": "protein_coding",
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          "end": 103380937,
          "strand": "+",
          "slug": "bex3"
        },
        {
          "symbol": "RAB40A",
          "ensemblId": "ENSG00000172476",
          "biotype": "protein_coding",
          "start": 103496510,
          "end": 103526752,
          "strand": "-",
          "slug": "rab40a"
        },
        {
          "symbol": "TCEAL4",
          "ensemblId": "ENSG00000133142",
          "biotype": "protein_coding",
          "start": 103576231,
          "end": 103590355,
          "strand": "+",
          "slug": "tceal4"
        },
        {
          "symbol": "TCEAL3",
          "ensemblId": "ENSG00000196507",
          "biotype": "protein_coding",
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          "end": 103629690,
          "strand": "+",
          "slug": "tceal3"
        },
        {
          "symbol": "MORF4L2",
          "ensemblId": "ENSG00000123562",
          "biotype": "protein_coding",
          "start": 103675316,
          "end": 103688158,
          "strand": "-",
          "slug": "morf4l2"
        },
        {
          "symbol": "TMEM31",
          "ensemblId": "ENSG00000179363",
          "biotype": "protein_coding",
          "start": 103710909,
          "end": 103714036,
          "strand": "+",
          "slug": "tmem31"
        },
        {
          "symbol": "PLP1",
          "ensemblId": "ENSG00000123560",
          "biotype": "protein_coding",
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          "end": 103792678,
          "strand": "+",
          "slug": "plp1"
        },
        {
          "symbol": "RAB9B",
          "ensemblId": "ENSG00000123570",
          "biotype": "protein_coding",
          "start": 103822327,
          "end": 103835153,
          "strand": "-",
          "slug": "rab9b"
        },
        {
          "symbol": "TMSB15B",
          "ensemblId": "ENSG00000158427",
          "biotype": "protein_coding",
          "start": 103918815,
          "end": 103966712,
          "strand": "+",
          "slug": "tmsb15b"
        },
        {
          "symbol": "H2BW1",
          "ensemblId": "ENSG00000123569",
          "biotype": "protein_coding",
          "start": 104011147,
          "end": 104013708,
          "strand": "-",
          "slug": "h2bw1"
        },
        {
          "symbol": "H2BW2",
          "ensemblId": "ENSG00000101812",
          "biotype": "protein_coding",
          "start": 104039956,
          "end": 104042454,
          "strand": "+",
          "slug": "h2bw2"
        },
        {
          "symbol": "TMSB15C",
          "ensemblId": "ENSG00000269226",
          "biotype": "protein_coding",
          "start": 104063871,
          "end": 104076236,
          "strand": "-",
          "slug": "tmsb15c"
        },
        {
          "symbol": "SLC25A53",
          "ensemblId": "ENSG00000269743",
          "biotype": "protein_coding",
          "start": 104099214,
          "end": 104157016,
          "strand": "-",
          "slug": "slc25a53"
        },
        {
          "symbol": "ZCCHC18",
          "ensemblId": "ENSG00000166707",
          "biotype": "protein_coding",
          "start": 104112060,
          "end": 104115851,
          "strand": "+",
          "slug": "zcchc18"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "gait-disturbance",
        "name": "Abnormal gait",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/gait-disturbance"
      },
      {
        "slug": "ankle-clonus",
        "name": "Abnormal rhythmic movements of ankle",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ankle-clonus"
      },
      {
        "slug": "gastroesophageal-reflux",
        "name": "Acid reflux",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/gastroesophageal-reflux"
      },
      {
        "slug": "astigmatism",
        "name": "Astigmatism",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/astigmatism"
      },
      {
        "slug": "autistic-behavior",
        "name": "Autism spectrum disorder",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/autistic-behavior"
      },
      {
        "slug": "broad-forehead",
        "name": "Broad forehead",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/broad-forehead"
      },
      {
        "slug": "iris-coloboma",
        "name": "Cat eye",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/iris-coloboma"
      },
      {
        "slug": "chronic-constipation",
        "name": "Chronic constipation",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/chronic-constipation"
      },
      {
        "slug": "strabismus",
        "name": "Cross-eyed",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/strabismus"
      },
      {
        "slug": "delayed-speech-and-language-development",
        "name": "Delayed speech and language development",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/delayed-speech-and-language-development"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "hypermetropia",
        "name": "Farsightedness",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypermetropia"
      },
      {
        "slug": "gastrostomy-tube-feeding-in-infancy",
        "name": "Gastrostomy tube feeding in infancy",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/gastrostomy-tube-feeding-in-infancy"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "postnatal-growth-retardation",
        "name": "Growth delay as children",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/postnatal-growth-retardation"
      },
      {
        "slug": "hyperbilirubinemia",
        "name": "High blood bilirubin levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hyperbilirubinemia"
      },
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "nystagmus",
        "name": "Involuntary, rapid, rhythmic eye movements",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/nystagmus"
      },
      {
        "slug": "developmental-regression",
        "name": "Loss of developmental milestones",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/developmental-regression"
      },
      {
        "slug": "hypotonia",
        "name": "Low muscle tone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypotonia"
      },
      {
        "slug": "lower-limb-spasticity",
        "name": "Lower limb spasticity",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/lower-limb-spasticity"
      },
      {
        "slug": "recurrent-ear-infections",
        "name": "Recurrent ear infections",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/recurrent-ear-infections"
      },
      {
        "slug": "recurrent-respiratory-infections",
        "name": "Recurrent respiratory infections",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/recurrent-respiratory-infections"
      },
      {
        "slug": "motor-stereotypy",
        "name": "Repetitive movements",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/motor-stereotypy"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}