{
  "url": "https://dantelabs.com/tr/genes/ptpn6",
  "gene": {
    "slug": "ptpn6",
    "symbol": "PTPN6",
    "name": "protein tyrosine phosphatase non-receptor type 6",
    "hgnc": "HGNC:9658",
    "summary": null,
    "location": "12p13.31",
    "locusType": "gene with protein product",
    "aliases": [
      "HCP",
      "HCPH",
      "PTP-1C",
      "SHP-1",
      "SHP1"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000111679",
    "entrezId": 5777,
    "omim": [
      "176883"
    ],
    "uniprot": [
      "P29350"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "12",
      "start": 6951356,
      "end": 6961316,
      "strand": "+",
      "ensemblTranscript": "ENST00000318974.14",
      "refseqTranscript": "NM_002831.6",
      "ensemblProtein": "ENSP00000326010.9",
      "refseqProtein": "NP_002822.2",
      "exons": [
        {
          "start": 6951356,
          "end": 6951520
        },
        {
          "start": 6951609,
          "end": 6951731
        },
        {
          "start": 6951983,
          "end": 6952177
        },
        {
          "start": 6954805,
          "end": 6954994
        },
        {
          "start": 6955151,
          "end": 6955267
        },
        {
          "start": 6955372,
          "end": 6955485
        },
        {
          "start": 6955660,
          "end": 6955756
        },
        {
          "start": 6956142,
          "end": 6956221
        },
        {
          "start": 6956419,
          "end": 6956568
        },
        {
          "start": 6957654,
          "end": 6957785
        },
        {
          "start": 6957919,
          "end": 6958073
        },
        {
          "start": 6959927,
          "end": 6959994
        },
        {
          "start": 6960088,
          "end": 6960239
        },
        {
          "start": 6960344,
          "end": 6960435
        },
        {
          "start": 6960806,
          "end": 6960945
        },
        {
          "start": 6961126,
          "end": 6961316
        }
      ],
      "cds": {
        "start": 6951513,
        "end": 6960920
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "12",
      "start": 7055631,
      "end": 7070479,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 6456336,
      "end": 7456335,
      "genes": [
        {
          "symbol": "TAPBPL",
          "ensemblId": "ENSG00000139192",
          "biotype": "protein_coding",
          "start": 6451690,
          "end": 6466517,
          "strand": "+",
          "slug": "tapbpl"
        },
        {
          "symbol": "VAMP1",
          "ensemblId": "ENSG00000139190",
          "biotype": "protein_coding",
          "start": 6462237,
          "end": 6470948,
          "strand": "-",
          "slug": "vamp1"
        },
        {
          "symbol": "MRPL51",
          "ensemblId": "ENSG00000111639",
          "biotype": "protein_coding",
          "start": 6490204,
          "end": 6493856,
          "strand": "-",
          "slug": "mrpl51"
        },
        {
          "symbol": "NCAPD2",
          "ensemblId": "ENSG00000010292",
          "biotype": "protein_coding",
          "start": 6493356,
          "end": 6531970,
          "strand": "+",
          "slug": "ncapd2"
        },
        {
          "symbol": "GAPDH",
          "ensemblId": "ENSG00000111640",
          "biotype": "protein_coding",
          "start": 6534012,
          "end": 6538930,
          "strand": "+",
          "slug": "gapdh"
        },
        {
          "symbol": "IFFO1",
          "ensemblId": "ENSG00000010295",
          "biotype": "protein_coding",
          "start": 6538961,
          "end": 6556102,
          "strand": "-",
          "slug": "iffo1"
        },
        {
          "symbol": "NOP2",
          "ensemblId": "ENSG00000111641",
          "biotype": "protein_coding",
          "start": 6556863,
          "end": 6568691,
          "strand": "-",
          "slug": "nop2"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000285238",
          "biotype": "protein_coding",
          "start": 6556886,
          "end": 6607367,
          "strand": "-"
        },
        {
          "symbol": "CHD4",
          "ensemblId": "ENSG00000111642",
          "biotype": "protein_coding",
          "start": 6570081,
          "end": 6614982,
          "strand": "-",
          "slug": "chd4"
        },
        {
          "symbol": "LPAR5",
          "ensemblId": "ENSG00000184574",
          "biotype": "protein_coding",
          "start": 6618835,
          "end": 6636444,
          "strand": "-",
          "slug": "lpar5"
        },
        {
          "symbol": "ACRBP",
          "ensemblId": "ENSG00000111644",
          "biotype": "protein_coding",
          "start": 6638075,
          "end": 6647441,
          "strand": "-",
          "slug": "acrbp"
        },
        {
          "symbol": "ING4",
          "ensemblId": "ENSG00000111653",
          "biotype": "protein_coding",
          "start": 6650282,
          "end": 6663180,
          "strand": "-",
          "slug": "ing4"
        },
        {
          "symbol": "ZNF384",
          "ensemblId": "ENSG00000126746",
          "biotype": "protein_coding",
          "start": 6665037,
          "end": 6689572,
          "strand": "-",
          "slug": "znf384"
        },
        {
          "symbol": "PIANP",
          "ensemblId": "ENSG00000139200",
          "biotype": "protein_coding",
          "start": 6693791,
          "end": 6700859,
          "strand": "-",
          "slug": "pianp"
        },
        {
          "symbol": "COPS7A",
          "ensemblId": "ENSG00000111652",
          "biotype": "protein_coding",
          "start": 6724014,
          "end": 6732462,
          "strand": "+",
          "slug": "cops7a"
        },
        {
          "symbol": "MLF2",
          "ensemblId": "ENSG00000089693",
          "biotype": "protein_coding",
          "start": 6747986,
          "end": 6768932,
          "strand": "-",
          "slug": "mlf2"
        },
        {
          "symbol": "PTMS",
          "ensemblId": "ENSG00000159335",
          "biotype": "protein_coding",
          "start": 6765516,
          "end": 6770952,
          "strand": "+",
          "slug": "ptms"
        },
        {
          "symbol": "LAG3",
          "ensemblId": "ENSG00000089692",
          "biotype": "protein_coding",
          "start": 6772360,
          "end": 6778455,
          "strand": "+",
          "slug": "lag3"
        },
        {
          "symbol": "CD4",
          "ensemblId": "ENSG00000010610",
          "biotype": "protein_coding",
          "start": 6786858,
          "end": 6820807,
          "strand": "+",
          "slug": "cd4"
        },
        {
          "symbol": "GPR162",
          "ensemblId": "ENSG00000250510",
          "biotype": "protein_coding",
          "start": 6821624,
          "end": 6829972,
          "strand": "+",
          "slug": "gpr162"
        },
        {
          "symbol": "P3H3",
          "ensemblId": "ENSG00000110811",
          "biotype": "protein_coding",
          "start": 6828220,
          "end": 6839867,
          "strand": "+",
          "slug": "p3h3"
        },
        {
          "symbol": "GNB3",
          "ensemblId": "ENSG00000111664",
          "biotype": "protein_coding",
          "start": 6839954,
          "end": 6847393,
          "strand": "+",
          "slug": "gnb3"
        },
        {
          "symbol": "CDCA3",
          "ensemblId": "ENSG00000111665",
          "biotype": "protein_coding",
          "start": 6844723,
          "end": 6852353,
          "strand": "-",
          "slug": "cdca3"
        },
        {
          "symbol": "USP5",
          "ensemblId": "ENSG00000111667",
          "biotype": "protein_coding",
          "start": 6852098,
          "end": 6866632,
          "strand": "+",
          "slug": "usp5"
        },
        {
          "symbol": "TPI1",
          "ensemblId": "ENSG00000111669",
          "biotype": "protein_coding",
          "start": 6867119,
          "end": 6878513,
          "strand": "+",
          "slug": "tpi1"
        },
        {
          "symbol": "SPSB2",
          "ensemblId": "ENSG00000111671",
          "biotype": "protein_coding",
          "start": 6870934,
          "end": 6889358,
          "strand": "-",
          "slug": "spsb2"
        },
        {
          "symbol": "LRRC23",
          "ensemblId": "ENSG00000010626",
          "biotype": "protein_coding",
          "start": 6873455,
          "end": 6914243,
          "strand": "+",
          "slug": "lrrc23"
        },
        {
          "symbol": "ENO2",
          "ensemblId": "ENSG00000111674",
          "biotype": "protein_coding",
          "start": 6913745,
          "end": 6923970,
          "strand": "+",
          "slug": "eno2"
        },
        {
          "symbol": "ATN1",
          "ensemblId": "ENSG00000111676",
          "biotype": "protein_coding",
          "start": 6924454,
          "end": 6942322,
          "strand": "+",
          "slug": "atn1"
        },
        {
          "symbol": "C12orf57",
          "ensemblId": "ENSG00000111678",
          "biotype": "protein_coding",
          "start": 6942919,
          "end": 6946009,
          "strand": "+",
          "slug": "c12orf57"
        },
        {
          "symbol": "RNU7-1",
          "ensemblId": "ENSG00000238923",
          "biotype": "other",
          "start": 6943816,
          "end": 6943878,
          "strand": "+",
          "slug": "rnu7-1"
        },
        {
          "symbol": "PHB2",
          "ensemblId": "ENSG00000215021",
          "biotype": "protein_coding",
          "start": 6965327,
          "end": 6970841,
          "strand": "-",
          "slug": "phb2"
        },
        {
          "symbol": "EMG1",
          "ensemblId": "ENSG00000126749",
          "biotype": "protein_coding",
          "start": 6970765,
          "end": 6979939,
          "strand": "+",
          "slug": "emg1"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000290146",
          "biotype": "protein_coding",
          "start": 6970921,
          "end": 6997428,
          "strand": "+"
        },
        {
          "symbol": "LPCAT3",
          "ensemblId": "ENSG00000111684",
          "biotype": "protein_coding",
          "start": 6972027,
          "end": 7018779,
          "strand": "-",
          "slug": "lpcat3"
        },
        {
          "symbol": "C1S",
          "ensemblId": "ENSG00000182326",
          "biotype": "protein_coding",
          "start": 6988259,
          "end": 7071281,
          "strand": "+",
          "slug": "c1s"
        },
        {
          "symbol": "C1R",
          "ensemblId": "ENSG00000159403",
          "biotype": "protein_coding",
          "start": 7080213,
          "end": 7092873,
          "strand": "-",
          "slug": "c1r"
        },
        {
          "symbol": "C1RL",
          "ensemblId": "ENSG00000139178",
          "biotype": "protein_coding",
          "start": 7089587,
          "end": 7109245,
          "strand": "-",
          "slug": "c1rl"
        },
        {
          "symbol": "RBP5",
          "ensemblId": "ENSG00000139194",
          "biotype": "protein_coding",
          "start": 7115736,
          "end": 7128891,
          "strand": "-",
          "slug": "rbp5"
        },
        {
          "symbol": "CLSTN3",
          "ensemblId": "ENSG00000139182",
          "biotype": "protein_coding",
          "start": 7128077,
          "end": 7158945,
          "strand": "+",
          "slug": "clstn3"
        },
        {
          "symbol": "PEX5",
          "ensemblId": "ENSG00000139197",
          "biotype": "protein_coding",
          "start": 7188653,
          "end": 7218574,
          "strand": "+",
          "slug": "pex5"
        },
        {
          "symbol": "ACSM4",
          "ensemblId": "ENSG00000215009",
          "biotype": "protein_coding",
          "start": 7304072,
          "end": 7328719,
          "strand": "+",
          "slug": "acsm4"
        },
        {
          "symbol": "CD163L1",
          "ensemblId": "ENSG00000177675",
          "biotype": "protein_coding",
          "start": 7346685,
          "end": 7479897,
          "strand": "-",
          "slug": "cd163l1"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-blistering-of-the-skin",
        "name": "Abnormal blistering of the skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-blistering-of-the-skin"
      },
      {
        "slug": "abnormal-circulating-interleukin-concentration",
        "name": "Abnormal circulating interleukin concentration",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-circulating-interleukin-concentration"
      },
      {
        "slug": "abnormal-drug-response",
        "name": "Abnormal drug response",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-drug-response"
      },
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "systems": [],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/neoplasm"
      },
      {
        "slug": "abnormality-of-the-face",
        "name": "Abnormality of the face",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-face"
      },
      {
        "slug": "abnormality-of-the-hand",
        "name": "Abnormality of the hand",
        "systems": [
          "abnormality-of-limbs"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-hand"
      },
      {
        "slug": "abnormality-of-the-neck",
        "name": "Abnormality of the neck",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-the-neck"
      },
      {
        "slug": "abnormality-of-tumor-necrosis-factor-secretion",
        "name": "Abnormality of tumor necrosis factor secretion",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abnormality-of-tumor-necrosis-factor-secretion"
      },
      {
        "slug": "acne",
        "name": "Acne",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/acne"
      },
      {
        "slug": "acne-inversa",
        "name": "Acne inversa",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/acne-inversa"
      },
      {
        "slug": "acute-myeloid-leukemia",
        "name": "Acute myeloid leukemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/acute-myeloid-leukemia"
      },
      {
        "slug": "hematological-neoplasm",
        "name": "Blood tumor",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "neoplasm"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hematological-neoplasm"
      },
      {
        "slug": "breast-carcinoma",
        "name": "Breast cancer",
        "systems": [
          "abnormality-of-the-breast",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/breast-carcinoma"
      },
      {
        "slug": "chronic-lymphatic-leukemia",
        "name": "Chronic lymphatic leukemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system",
          "neoplasm"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/chronic-lymphatic-leukemia"
      },
      {
        "slug": "elevated-circulating-c-reactive-protein-concentration",
        "name": "Elevated circulating C-reactive protein concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/elevated-circulating-c-reactive-protein-concentration"
      },
      {
        "slug": "increased-total-leukocyte-count",
        "name": "Elevated white blood count",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/increased-total-leukocyte-count"
      },
      {
        "slug": "erythematous-papule",
        "name": "Erythematous papule",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/erythematous-papule"
      },
      {
        "slug": "erythematous-plaque",
        "name": "Erythematous plaque",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/erythematous-plaque"
      },
      {
        "slug": "elevated-erythrocyte-sedimentation-rate",
        "name": "High ESR",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/elevated-erythrocyte-sedimentation-rate"
      },
      {
        "slug": "increased-total-neutrophil-count",
        "name": "Increased blood neutrophil counts",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/increased-total-neutrophil-count"
      },
      {
        "slug": "increased-circulating-interleukin-6-concentration",
        "name": "Increased circulating interleukin 6 concentration",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/increased-circulating-interleukin-6-concentration"
      },
      {
        "slug": "panniculitis",
        "name": "Inflammation of fat tissue",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/panniculitis"
      },
      {
        "slug": "inflammation-of-the-large-intestine",
        "name": "Inflammation of the large intestine",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/inflammation-of-the-large-intestine"
      },
      {
        "slug": "arthralgia",
        "name": "Joint pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/arthralgia"
      },
      {
        "slug": "anemia",
        "name": "Low number of red blood cells or hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/anemia"
      },
      {
        "slug": "myalgia",
        "name": "Muscle ache",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/myalgia"
      },
      {
        "slug": "myositis",
        "name": "Muscle inflammation",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/myositis"
      },
      {
        "slug": "non-periodic-recurrent-fever",
        "name": "Non-periodic recurrent fever",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/non-periodic-recurrent-fever"
      },
      {
        "slug": "oligoarthritis",
        "name": "Oligoarthritis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/oligoarthritis"
      },
      {
        "slug": "pain",
        "name": "Pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/pain"
      },
      {
        "slug": "pustule",
        "name": "Pimple",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pustule"
      },
      {
        "slug": "predominantly-dermal-neutrophilic-infiltrate",
        "name": "Predominantly dermal neutrophilic infiltrate",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/predominantly-dermal-neutrophilic-infiltrate"
      },
      {
        "slug": "pyoderma-gangrenosum",
        "name": "Pyoderma gangrenosum",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pyoderma-gangrenosum"
      },
      {
        "slug": "recurrent-infections",
        "name": "Recurrent infections",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/recurrent-infections"
      },
      {
        "slug": "skin-nodule",
        "name": "Skin nodule",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/skin-nodule"
      },
      {
        "slug": "skin-vesicle",
        "name": "Skin vesicle",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/skin-vesicle"
      },
      {
        "slug": "small-vessel-vasculitis",
        "name": "Small vessel vasculitis",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/small-vessel-vasculitis"
      },
      {
        "slug": "sterile-abscess",
        "name": "Sterile abscess",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/sterile-abscess"
      },
      {
        "slug": "dilated-cardiomyopathy",
        "name": "Stretched and thinned heart muscle",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/dilated-cardiomyopathy"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}