{
  "url": "https://dantelabs.com/tr/genes/mns1",
  "gene": {
    "slug": "mns1",
    "symbol": "MNS1",
    "name": "meiosis specific nuclear structural 1",
    "hgnc": "HGNC:29636",
    "summary": null,
    "location": "15q21.3",
    "locusType": "gene with protein product",
    "aliases": [
      "CFAP127",
      "FLJ11222",
      "SPATA40"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000138587",
    "entrezId": 55329,
    "omim": [
      "610766"
    ],
    "uniprot": [
      "Q8NEH6"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "15",
      "start": 56428724,
      "end": 56465137,
      "strand": "-",
      "ensemblTranscript": "ENST00000260453.4",
      "refseqTranscript": "NM_018365.4",
      "ensemblProtein": "ENSP00000260453.3",
      "refseqProtein": "NP_060835.1",
      "exons": [
        {
          "start": 56428724,
          "end": 56429193
        },
        {
          "start": 56431373,
          "end": 56431498
        },
        {
          "start": 56434138,
          "end": 56434395
        },
        {
          "start": 56443430,
          "end": 56443537
        },
        {
          "start": 56443638,
          "end": 56443854
        },
        {
          "start": 56444444,
          "end": 56444673
        },
        {
          "start": 56446841,
          "end": 56446943
        },
        {
          "start": 56456394,
          "end": 56456521
        },
        {
          "start": 56464026,
          "end": 56464247
        },
        {
          "start": 56464970,
          "end": 56465137
        }
      ],
      "cds": {
        "start": 56429101,
        "end": 56464972
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "15",
      "start": 56713742,
      "end": 56757335,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 55946931,
      "end": 56946930,
      "genes": [
        {
          "symbol": "NEDD4",
          "ensemblId": "ENSG00000069869",
          "biotype": "protein_coding",
          "start": 55826917,
          "end": 55993660,
          "strand": "-",
          "slug": "nedd4"
        },
        {
          "symbol": "RFX7",
          "ensemblId": "ENSG00000181827",
          "biotype": "protein_coding",
          "start": 56087280,
          "end": 56245103,
          "strand": "-",
          "slug": "rfx7"
        },
        {
          "symbol": "TEX9",
          "ensemblId": "ENSG00000151575",
          "biotype": "protein_coding",
          "start": 56243971,
          "end": 56445997,
          "strand": "+",
          "slug": "tex9"
        },
        {
          "symbol": "ZNF280D",
          "ensemblId": "ENSG00000137871",
          "biotype": "protein_coding",
          "start": 56630164,
          "end": 56734086,
          "strand": "-",
          "slug": "znf280d"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000285253",
          "biotype": "protein_coding",
          "start": 56652488,
          "end": 56918571,
          "strand": "-"
        },
        {
          "symbol": "TCF12",
          "ensemblId": "ENSG00000140262",
          "biotype": "protein_coding",
          "start": 56918099,
          "end": 57299707,
          "strand": "+",
          "slug": "tcf12"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "heterotaxy-laterality-defects",
        "name": "Heterotaksi ve Laterilite Bozuklukları",
        "diseases": [
          {
            "mondoId": "MONDO:0018677",
            "name": "Viseral Heterotaksi",
            "genes": 11,
            "inheritance": null,
            "description": "ZIC3 (X'e bağlı), NODAL, CFC1, MMP21 ve PKD1L1 gibi genlerdeki değişikliklerin neden olduğu, iç organların anormal sağ-sol düzenlenmesi; genellikle karmaşık kalp defektleri ve dalak anormallikleriyle birlikte görülür.",
            "management": "Bu durumu bilmek kalp ve karın görüntülemesini, dalak yoksa enfeksiyon önlemlerini ve üreme danışmanlığını destekler.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/tr/conditions/heterotaxy-laterality-defects"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "asplenia",
        "name": "Absent spleen",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/asplenia"
      },
      {
        "slug": "situs-inversus-totalis",
        "name": "All organs on wrong side of body",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/situs-inversus-totalis"
      },
      {
        "slug": "dextrocardia",
        "name": "Heart tip and four chambers point towards right side of body",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/dextrocardia"
      },
      {
        "slug": "male-infertility",
        "name": "Male infertility",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/male-infertility"
      },
      {
        "slug": "recurrent-otitis-media",
        "name": "Recurrent middle ear infection",
        "systems": [
          "abnormality-of-the-ear",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/recurrent-otitis-media"
      }
    ],
    "related": [
      {
        "slug": "acvr2b",
        "symbol": "ACVR2B",
        "name": "activin A receptor type 2B",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/acvr2b"
      },
      {
        "slug": "cfap53",
        "symbol": "CFAP53",
        "name": "cilia and flagella associated protein 53",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/cfap53"
      },
      {
        "slug": "cfc1",
        "symbol": "CFC1",
        "name": "cryptic, EGF-CFC family member 1",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/cfc1"
      },
      {
        "slug": "cirop",
        "symbol": "CIROP",
        "name": "ciliated left-right organizer metallopeptidase",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/cirop"
      },
      {
        "slug": "daw1",
        "symbol": "DAW1",
        "name": "dynein assembly factor with WD repeats 1",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/daw1"
      },
      {
        "slug": "gdf1",
        "symbol": "GDF1",
        "name": "growth differentiation factor 1",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/gdf1"
      },
      {
        "slug": "mmp21",
        "symbol": "MMP21",
        "name": "matrix metallopeptidase 21",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/mmp21"
      },
      {
        "slug": "nodal",
        "symbol": "NODAL",
        "name": "nodal growth differentiation factor",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/nodal"
      },
      {
        "slug": "pkd1l1",
        "symbol": "PKD1L1",
        "name": "polycystin 1 like 1, transient receptor potential channel interacting",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/pkd1l1"
      },
      {
        "slug": "zic3",
        "symbol": "ZIC3",
        "name": "Zic family zinc finger 3",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/zic3"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}