{
  "url": "https://dantelabs.com/tr/genes/klk4",
  "gene": {
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    "symbol": "KLK4",
    "name": "kallikrein related peptidase 4",
    "hgnc": "HGNC:6365",
    "summary": null,
    "location": "19q13.41",
    "locusType": "gene with protein product",
    "aliases": [
      "EMSP",
      "EMSP1",
      "PSTS",
      "KLK-L1"
    ],
    "previousSymbols": [
      "PRSS17"
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    "entrezId": 9622,
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    "uniprot": [
      "Q9Y5K2"
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      "release": "v1.5",
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      "ensemblTranscript": "ENST00000324041.6",
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      "refseqProtein": "NP_004908.4",
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    },
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        {
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        {
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          "symbol": "SYT3",
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          "symbol": "C19orf81",
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        {
          "symbol": "SHANK1",
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        {
          "symbol": "CLEC11A",
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        {
          "symbol": "GPR32",
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        {
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        {
          "symbol": "ACP4",
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          "slug": "acp4"
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        {
          "symbol": "KLK1",
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        {
          "symbol": "KLK15",
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        {
          "symbol": "KLK3",
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        {
          "symbol": "KLK2",
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        {
          "symbol": "KLK5",
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          "slug": "klk5"
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        {
          "symbol": "KLK6",
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          "slug": "klk6"
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        {
          "symbol": "KLK7",
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          "slug": "klk7"
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        {
          "symbol": "KLK8",
          "ensemblId": "ENSG00000129455",
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          "slug": "klk8"
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        {
          "symbol": "",
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        {
          "symbol": "KLK9",
          "ensemblId": "ENSG00000213022",
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          "slug": "klk9"
        },
        {
          "symbol": "KLK10",
          "ensemblId": "ENSG00000129451",
          "biotype": "protein_coding",
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          "slug": "klk10"
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        {
          "symbol": "KLK11",
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        {
          "symbol": "KLK12",
          "ensemblId": "ENSG00000186474",
          "biotype": "protein_coding",
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        {
          "symbol": "KLK13",
          "ensemblId": "ENSG00000167759",
          "biotype": "protein_coding",
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          "slug": "klk13"
        },
        {
          "symbol": "KLK14",
          "ensemblId": "ENSG00000129437",
          "biotype": "protein_coding",
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        {
          "symbol": "CTU1",
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        {
          "symbol": "SIGLEC9",
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        },
        {
          "symbol": "SIGLEC7",
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          "biotype": "protein_coding",
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        },
        {
          "symbol": "CD33",
          "ensemblId": "ENSG00000105383",
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        },
        {
          "symbol": "SIGLECL1",
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          "biotype": "protein_coding",
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          "slug": "siglecl1"
        },
        {
          "symbol": "IGLON5",
          "ensemblId": "ENSG00000142549",
          "biotype": "protein_coding",
          "start": 51311639,
          "end": 51330891,
          "strand": "+",
          "slug": "iglon5"
        },
        {
          "symbol": "VSIG10L",
          "ensemblId": "ENSG00000186806",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "ETFB",
          "ensemblId": "ENSG00000105379",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "etfb"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000269403",
          "biotype": "protein_coding",
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        },
        {
          "symbol": "CLDND2",
          "ensemblId": "ENSG00000160318",
          "biotype": "protein_coding",
          "start": 51367098,
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          "strand": "-",
          "slug": "cldnd2"
        },
        {
          "symbol": "NKG7",
          "ensemblId": "ENSG00000105374",
          "biotype": "protein_coding",
          "start": 51371606,
          "end": 51375628,
          "strand": "-",
          "slug": "nkg7"
        },
        {
          "symbol": "LIM2",
          "ensemblId": "ENSG00000105370",
          "biotype": "protein_coding",
          "start": 51379909,
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          "strand": "-",
          "slug": "lim2"
        },
        {
          "symbol": "C19orf84",
          "ensemblId": "ENSG00000262874",
          "biotype": "protein_coding",
          "start": 51388289,
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          "strand": "-",
          "slug": "c19orf84"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "amelogenesis-imperfecta",
        "name": "Amelogenez İmperfekta",
        "diseases": [
          {
            "mondoId": "MONDO:0019507",
            "name": "amelogenez imperfekta",
            "genes": 17,
            "inheritance": "autosomal-dominant",
            "description": null,
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/tr/conditions/amelogenesis-imperfecta"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "anterior-open-bite-malocclusion",
        "name": "Absence of overlap of anterior upper and lower teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/anterior-open-bite-malocclusion"
      },
      {
        "slug": "amelogenesis-imperfecta",
        "name": "Amelogenesis imperfecta",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/amelogenesis-imperfecta"
      },
      {
        "slug": "carious-teeth",
        "name": "Dental cavities",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/carious-teeth"
      },
      {
        "slug": "enamel-hypomineralization",
        "name": "Poorly mineralized tooth enamel",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/enamel-hypomineralization"
      },
      {
        "slug": "yellow-brown-discoloration-of-the-teeth",
        "name": "Yellow-brown discoloration of the teeth",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/yellow-brown-discoloration-of-the-teeth"
      }
    ],
    "related": [
      {
        "slug": "acp4",
        "symbol": "ACP4",
        "name": "acid phosphatase 4",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/acp4"
      },
      {
        "slug": "ambn",
        "symbol": "AMBN",
        "name": "ameloblastin",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/ambn"
      },
      {
        "slug": "amelx",
        "symbol": "AMELX",
        "name": "amelogenin X-linked",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/amelx"
      },
      {
        "slug": "dlx3",
        "symbol": "DLX3",
        "name": "distal-less homeobox 3",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/dlx3"
      },
      {
        "slug": "enam",
        "symbol": "ENAM",
        "name": "enamelin",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/enam"
      },
      {
        "slug": "fam20a",
        "symbol": "FAM20A",
        "name": "FAM20A golgi associated secretory pathway pseudokinase",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/fam20a"
      },
      {
        "slug": "gpr68",
        "symbol": "GPR68",
        "name": "G protein-coupled receptor 68",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/gpr68"
      },
      {
        "slug": "itgb6",
        "symbol": "ITGB6",
        "name": "integrin subunit beta 6",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/itgb6"
      },
      {
        "slug": "lamb3",
        "symbol": "LAMB3",
        "name": "laminin subunit beta 3",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/lamb3"
      },
      {
        "slug": "mmp20",
        "symbol": "MMP20",
        "name": "matrix metallopeptidase 20",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/mmp20"
      },
      {
        "slug": "odaph",
        "symbol": "ODAPH",
        "name": "odontogenesis associated phosphoprotein",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/odaph"
      },
      {
        "slug": "relt",
        "symbol": "RELT",
        "name": "RELT TNF receptor",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/relt"
      }
    ],
    "sources": {
      "bundleId": "2026.10.16-c6eea6bf",
      "panel": "2026-10-16",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}