{
  "url": "https://dantelabs.com/tr/genes/klf4",
  "gene": {
    "slug": "klf4",
    "symbol": "KLF4",
    "name": "KLF transcription factor 4",
    "hgnc": "HGNC:6348",
    "summary": null,
    "location": "9q31.2",
    "locusType": "gene with protein product",
    "aliases": [
      "EZF",
      "GKLF"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000136826",
    "entrezId": 9314,
    "omim": [
      "602253"
    ],
    "uniprot": [
      "O43474"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "9",
      "start": 107484852,
      "end": 107489769,
      "strand": "-",
      "ensemblTranscript": "ENST00000374672.5",
      "refseqTranscript": "NM_004235.6",
      "ensemblProtein": "ENSP00000363804.4",
      "refseqProtein": "NP_004226.3",
      "exons": [
        {
          "start": 107484852,
          "end": 107485926
        },
        {
          "start": 107487028,
          "end": 107487192
        },
        {
          "start": 107487295,
          "end": 107488267
        },
        {
          "start": 107488930,
          "end": 107489050
        },
        {
          "start": 107489168,
          "end": 107489769
        }
      ],
      "cds": {
        "start": 107485751,
        "end": 107489172
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "9",
      "start": 110247133,
      "end": 110252763,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 106987311,
      "end": 107987310,
      "genes": [
        {
          "symbol": "ZNF462",
          "ensemblId": "ENSG00000148143",
          "biotype": "protein_coding",
          "start": 106862286,
          "end": 107013634,
          "strand": "+",
          "slug": "znf462"
        },
        {
          "symbol": "RAD23B",
          "ensemblId": "ENSG00000119318",
          "biotype": "protein_coding",
          "start": 107283137,
          "end": 107332192,
          "strand": "+",
          "slug": "rad23b"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "hereditary-palmoplantar-keratodermas",
        "name": "Kalıtsal Palmoplantar Keratodermler ve Pachyonychia Congenita",
        "diseases": [
          {
            "mondoId": "MONDO:0019272",
            "name": "Kalıtsal palmoplantar keratoderma",
            "genes": 35,
            "inheritance": null,
            "description": "Pachyonychia congenita, mal de Meleda, Nagashima tipi ve Bothnia keratodermaları, keratitis-ichthyosis-deafness sendromu ve CTSC ile ilişkili Papillon-Lefèvre ve Haim-Munk sendromları dahil olmak üzere, avuç içlerinin ve ayak tabanlarının kalıtsal kalınlaşması.",
            "management": "Tanı, ayak bakımına ve ağrı yönetimine yön verir; CTSC ile ilişkili formlarda erken diş tedavisi dişleri korur, GJB2 ile ilişkili formlarda ise işitme kontrolü önerilir.",
            "evidence": {
              "gencc": [
                "PanelApp Australia"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/tr/conditions/hereditary-palmoplantar-keratodermas"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [],
    "related": [
      {
        "slug": "aagab",
        "symbol": "AAGAB",
        "name": "alpha and gamma adaptin binding protein",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/aagab"
      },
      {
        "slug": "ap1b1",
        "symbol": "AP1B1",
        "name": "adaptor related protein complex 1 subunit beta 1",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/ap1b1"
      },
      {
        "slug": "aqp5",
        "symbol": "AQP5",
        "name": "aquaporin 5",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/aqp5"
      },
      {
        "slug": "ctsc",
        "symbol": "CTSC",
        "name": "cathepsin C",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/ctsc"
      },
      {
        "slug": "dsg1",
        "symbol": "DSG1",
        "name": "desmoglein 1",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/dsg1"
      },
      {
        "slug": "dsp",
        "symbol": "DSP",
        "name": "desmoplakin",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/dsp"
      },
      {
        "slug": "gja1",
        "symbol": "GJA1",
        "name": "gap junction protein alpha 1",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/gja1"
      },
      {
        "slug": "gjb2",
        "symbol": "GJB2",
        "name": "gap junction protein beta 2",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/gjb2"
      },
      {
        "slug": "gjb3",
        "symbol": "GJB3",
        "name": "gap junction protein beta 3",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/gjb3"
      },
      {
        "slug": "gjb4",
        "symbol": "GJB4",
        "name": "gap junction protein beta 4",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/gjb4"
      },
      {
        "slug": "gjb6",
        "symbol": "GJB6",
        "name": "gap junction protein beta 6",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/gjb6"
      },
      {
        "slug": "grhl2",
        "symbol": "GRHL2",
        "name": "grainyhead like transcription factor 2",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/grhl2"
      }
    ],
    "sources": {
      "bundleId": "2026.10.16-c6eea6bf",
      "panel": "2026-10-16",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}