{
  "url": "https://dantelabs.com/tr/genes/il21",
  "gene": {
    "slug": "il21",
    "symbol": "IL21",
    "name": "interleukin 21",
    "hgnc": "HGNC:6005",
    "summary": null,
    "location": "4q27",
    "locusType": "gene with protein product",
    "aliases": [
      "Za11",
      "IL-21"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000138684",
    "entrezId": 59067,
    "omim": [
      "605384"
    ],
    "uniprot": [
      "Q9HBE4"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "4",
      "start": 122610108,
      "end": 122621066,
      "strand": "-",
      "ensemblTranscript": "ENST00000648588.1",
      "refseqTranscript": "NM_021803.4",
      "ensemblProtein": "ENSP00000497915.1",
      "refseqProtein": "NP_068575.1",
      "exons": [
        {
          "start": 122610108,
          "end": 122612760
        },
        {
          "start": 122612851,
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        },
        {
          "start": 122615682,
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        },
        {
          "start": 122620701,
          "end": 122620736
        },
        {
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        }
      ],
      "cds": {
        "start": 122612710,
        "end": 122621011
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "4",
      "start": 123533783,
      "end": 123542224,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 122115587,
      "end": 123115586,
      "genes": [
        {
          "symbol": "BLTP1",
          "ensemblId": "ENSG00000138688",
          "biotype": "protein_coding",
          "start": 122152327,
          "end": 122364167,
          "strand": "+",
          "slug": "bltp1"
        },
        {
          "symbol": "ADAD1",
          "ensemblId": "ENSG00000164113",
          "biotype": "protein_coding",
          "start": 122378966,
          "end": 122429814,
          "strand": "+",
          "slug": "adad1"
        },
        {
          "symbol": "IL2",
          "ensemblId": "ENSG00000109471",
          "biotype": "protein_coding",
          "start": 122451470,
          "end": 122456725,
          "strand": "-",
          "slug": "il2"
        },
        {
          "symbol": "BBS12",
          "ensemblId": "ENSG00000181004",
          "biotype": "protein_coding",
          "start": 122732653,
          "end": 122746078,
          "strand": "+",
          "slug": "bbs12"
        },
        {
          "symbol": "FGF2",
          "ensemblId": "ENSG00000138685",
          "biotype": "protein_coding",
          "start": 122826680,
          "end": 122898236,
          "strand": "+",
          "slug": "fgf2"
        },
        {
          "symbol": "NUDT6",
          "ensemblId": "ENSG00000170917",
          "biotype": "protein_coding",
          "start": 122886565,
          "end": 122922968,
          "strand": "-",
          "slug": "nudt6"
        },
        {
          "symbol": "AFG2A",
          "ensemblId": "ENSG00000145375",
          "biotype": "protein_coding",
          "start": 122923070,
          "end": 123319433,
          "strand": "+",
          "slug": "afg2a"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "aphthous-ulcer",
        "name": "Canker sore",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/aphthous-ulcer"
      },
      {
        "slug": "clubbing-of-fingers",
        "name": "Clubbing of fingers",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/clubbing-of-fingers"
      },
      {
        "slug": "crohn-s-disease",
        "name": "Crohn's disease",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/crohn-s-disease"
      },
      {
        "slug": "decreased-circulating-igg-concentration",
        "name": "Decreased circulating IgG concentration",
        "systems": [
          "abnormal-cellular-phenotype",
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-circulating-igg-concentration"
      },
      {
        "slug": "decreased-class-switched-memory-b-cell-proportion",
        "name": "Decreased class-switched memory B cell proportion",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-class-switched-memory-b-cell-proportion"
      },
      {
        "slug": "failure-to-thrive",
        "name": "Faltering weight",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/failure-to-thrive"
      },
      {
        "slug": "fatigue",
        "name": "Fatigue",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/fatigue"
      },
      {
        "slug": "growth-delay",
        "name": "Growth delay",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/growth-delay"
      },
      {
        "slug": "increased-circulating-ige-concentration",
        "name": "Increased circulating IgE concentration",
        "systems": [
          "abnormal-cellular-phenotype",
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/increased-circulating-ige-concentration"
      },
      {
        "slug": "inflammation-of-the-large-intestine",
        "name": "Inflammation of the large intestine",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/inflammation-of-the-large-intestine"
      },
      {
        "slug": "mucoid-diarrhea",
        "name": "Mucoid diarrhea",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/mucoid-diarrhea"
      },
      {
        "slug": "recurrent-respiratory-infections",
        "name": "Recurrent respiratory infections",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/recurrent-respiratory-infections"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}