{
  "url": "https://dantelabs.com/tr/genes/hal",
  "gene": {
    "slug": "hal",
    "symbol": "HAL",
    "name": "histidine ammonia-lyase",
    "hgnc": "HGNC:4806",
    "summary": null,
    "location": "12q23.1",
    "locusType": "gene with protein product",
    "aliases": [],
    "previousSymbols": [
      "HIS"
    ],
    "ensemblId": "ENSG00000084110",
    "entrezId": 3034,
    "omim": [
      "609457"
    ],
    "uniprot": [
      "P42357"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "12",
      "start": 95972662,
      "end": 95996344,
      "strand": "-",
      "ensemblTranscript": "ENST00000261208.8",
      "refseqTranscript": "NM_002108.4",
      "ensemblProtein": "ENSP00000261208.3",
      "refseqProtein": "NP_002099.1",
      "exons": [
        {
          "start": 95972662,
          "end": 95974372
        },
        {
          "start": 95976429,
          "end": 95976498
        },
        {
          "start": 95976598,
          "end": 95976706
        },
        {
          "start": 95977944,
          "end": 95978078
        },
        {
          "start": 95980556,
          "end": 95980721
        },
        {
          "start": 95980798,
          "end": 95980863
        },
        {
          "start": 95983911,
          "end": 95983991
        },
        {
          "start": 95985908,
          "end": 95985966
        },
        {
          "start": 95986065,
          "end": 95986160
        },
        {
          "start": 95987067,
          "end": 95987214
        },
        {
          "start": 95988193,
          "end": 95988240
        },
        {
          "start": 95990393,
          "end": 95990532
        },
        {
          "start": 95992680,
          "end": 95992805
        },
        {
          "start": 95993451,
          "end": 95993488
        },
        {
          "start": 95993772,
          "end": 95993838
        },
        {
          "start": 95993926,
          "end": 95993998
        },
        {
          "start": 95994090,
          "end": 95994164
        },
        {
          "start": 95994798,
          "end": 95994825
        },
        {
          "start": 95994933,
          "end": 95994993
        },
        {
          "start": 95995664,
          "end": 95995991
        },
        {
          "start": 95996078,
          "end": 95996344
        }
      ],
      "cds": {
        "start": 95974232,
        "end": 95995910
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "12",
      "start": 96366440,
      "end": 96390143,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 95484503,
      "end": 96484502,
      "genes": [
        {
          "symbol": "METAP2",
          "ensemblId": "ENSG00000111142",
          "biotype": "protein_coding",
          "start": 95473520,
          "end": 95515935,
          "strand": "+",
          "slug": "metap2"
        },
        {
          "symbol": "USP44",
          "ensemblId": "ENSG00000136014",
          "biotype": "protein_coding",
          "start": 95515926,
          "end": 95553341,
          "strand": "-",
          "slug": "usp44"
        },
        {
          "symbol": "NTN4",
          "ensemblId": "ENSG00000074527",
          "biotype": "protein_coding",
          "start": 95657529,
          "end": 95791373,
          "strand": "-",
          "slug": "ntn4"
        },
        {
          "symbol": "SNRPF",
          "ensemblId": "ENSG00000139343",
          "biotype": "protein_coding",
          "start": 95858762,
          "end": 95903828,
          "strand": "+",
          "slug": "snrpf"
        },
        {
          "symbol": "CCDC38",
          "ensemblId": "ENSG00000165972",
          "biotype": "protein_coding",
          "start": 95867048,
          "end": 95942680,
          "strand": "-",
          "slug": "ccdc38"
        },
        {
          "symbol": "AMDHD1",
          "ensemblId": "ENSG00000139344",
          "biotype": "protein_coding",
          "start": 95943046,
          "end": 95968830,
          "strand": "+",
          "slug": "amdhd1"
        },
        {
          "symbol": "LTA4H",
          "ensemblId": "ENSG00000111144",
          "biotype": "protein_coding",
          "start": 96000298,
          "end": 96043523,
          "strand": "-",
          "slug": "lta4h"
        },
        {
          "symbol": "ELK3",
          "ensemblId": "ENSG00000111145",
          "biotype": "protein_coding",
          "start": 96193978,
          "end": 96269835,
          "strand": "+",
          "slug": "elk3"
        },
        {
          "symbol": "CDK17",
          "ensemblId": "ENSG00000059758",
          "biotype": "protein_coding",
          "start": 96278227,
          "end": 96400597,
          "strand": "-",
          "slug": "cdk17"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-speech-pattern",
        "name": "Abnormal speech pattern",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/abnormal-speech-pattern"
      },
      {
        "slug": "atypical-behavior",
        "name": "Behavioral abnormality",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/atypical-behavior"
      },
      {
        "slug": "elevated-urinary-n-tau-ribosylhistidine-level",
        "name": "Elevated urinary N-tau-ribosylhistidine level",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/elevated-urinary-n-tau-ribosylhistidine-level"
      },
      {
        "slug": "hyperhistidinemia",
        "name": "High blood histidine level",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hyperhistidinemia"
      },
      {
        "slug": "histidinuria",
        "name": "High urine histidine levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/histidinuria"
      },
      {
        "slug": "moderate-global-developmental-delay",
        "name": "Moderate global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/moderate-global-developmental-delay"
      },
      {
        "slug": "hyperactivity",
        "name": "More active than typical",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/hyperactivity"
      },
      {
        "slug": "specific-learning-disability",
        "name": "Specific learning disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/specific-learning-disability"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}