{
  "url": "https://dantelabs.com/tr/genes/fbxo43",
  "gene": {
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    "symbol": "FBXO43",
    "name": "F-box protein 43",
    "hgnc": "HGNC:28521",
    "summary": null,
    "location": "8q22.2",
    "locusType": "gene with protein product",
    "aliases": [
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    "previousSymbols": [],
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    "entrezId": 286151,
    "omim": [
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    "uniprot": [
      "Q4G163"
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      "release": "v1.5",
      "chrom": "8",
      "start": 100133351,
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      "strand": "-",
      "ensemblTranscript": "ENST00000428847.3",
      "refseqTranscript": "NM_001029860.4",
      "ensemblProtein": "ENSP00000403293.2",
      "refseqProtein": "NP_001025031.2",
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    },
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      "strand": "-"
    },
    "neighbourhood": {
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        {
          "symbol": "VPS13B",
          "ensemblId": "ENSG00000132549",
          "biotype": "protein_coding",
          "start": 99013254,
          "end": 99877580,
          "strand": "+",
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        },
        {
          "symbol": "COX6C",
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          "biotype": "protein_coding",
          "start": 99870615,
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          "strand": "-",
          "slug": "cox6c"
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        {
          "symbol": "RGS22",
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          "biotype": "protein_coding",
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          "end": 100131268,
          "strand": "-",
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        },
        {
          "symbol": "POLR2K",
          "ensemblId": "ENSG00000147669",
          "biotype": "protein_coding",
          "start": 100150610,
          "end": 100154005,
          "strand": "+",
          "slug": "polr2k"
        },
        {
          "symbol": "SPAG1",
          "ensemblId": "ENSG00000104450",
          "biotype": "protein_coding",
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        },
        {
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          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "rnf19a"
        },
        {
          "symbol": "ANKRD46",
          "ensemblId": "ENSG00000186106",
          "biotype": "protein_coding",
          "start": 100509752,
          "end": 100559789,
          "strand": "-",
          "slug": "ankrd46"
        },
        {
          "symbol": "SNX31",
          "ensemblId": "ENSG00000174226",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "snx31"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abnormal-meiosis",
        "name": "Abnormal meiosis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/abnormal-meiosis"
      },
      {
        "slug": "abnormal-oocyte-morphology",
        "name": "Abnormal oocyte morphology",
        "systems": [
          "abnormal-cellular-phenotype"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abnormal-oocyte-morphology"
      },
      {
        "slug": "abnormal-preimplantation-embryonic-development",
        "name": "Abnormal preimplantation embryonic development",
        "systems": [
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        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/abnormal-preimplantation-embryonic-development"
      },
      {
        "slug": "abnormal-spermatogenesis",
        "name": "Abnormal sperm development",
        "systems": [
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        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/abnormal-spermatogenesis"
      },
      {
        "slug": "abnormal-sperm-head-morphology",
        "name": "Abnormal sperm head morphology",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/abnormal-sperm-head-morphology"
      },
      {
        "slug": "azoospermia",
        "name": "Absent sperm in semen",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/azoospermia"
      },
      {
        "slug": "decreased-testicular-size",
        "name": "Decreased testicular size",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/decreased-testicular-size"
      },
      {
        "slug": "female-infertility",
        "name": "Female infertility",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/female-infertility"
      },
      {
        "slug": "increased-circulating-gonadotropin-level",
        "name": "Increased circulating gonadotropin level",
        "systems": [
          "abnormality-of-the-endocrine-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/increased-circulating-gonadotropin-level"
      },
      {
        "slug": "oligozoospermia",
        "name": "Low sperm count",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/oligozoospermia"
      },
      {
        "slug": "male-infertility",
        "name": "Male infertility",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/male-infertility"
      },
      {
        "slug": "metaphase-i-oocyte-maturation-arrest",
        "name": "Metaphase I oocyte maturation arrest",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/metaphase-i-oocyte-maturation-arrest"
      },
      {
        "slug": "non-obstructive-azoospermia",
        "name": "Non-obstructive azoospermia",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/non-obstructive-azoospermia"
      },
      {
        "slug": "obstructive-azoospermia",
        "name": "Obstructive azoospermia",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/obstructive-azoospermia"
      },
      {
        "slug": "polycystic-ovaries",
        "name": "Polycystic ovaries",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/polycystic-ovaries"
      },
      {
        "slug": "reduced-progressive-sperm-motility",
        "name": "Reduced progressive sperm motility",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/reduced-progressive-sperm-motility"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}