{
  "url": "https://dantelabs.com/tr/genes/dnah8",
  "gene": {
    "slug": "dnah8",
    "symbol": "DNAH8",
    "name": "dynein axonemal heavy chain 8",
    "hgnc": "HGNC:2952",
    "summary": null,
    "location": "6p21.2",
    "locusType": "gene with protein product",
    "aliases": [
      "hdhc9"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000124721",
    "entrezId": 1769,
    "omim": [
      "603337"
    ],
    "uniprot": [
      "Q96JB1"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "6",
      "start": 38715311,
      "end": 39030792,
      "strand": "+",
      "ensemblTranscript": "ENST00000327475.11",
      "refseqTranscript": "NM_001206927.2",
      "ensemblProtein": "ENSP00000333363.7",
      "refseqProtein": "NP_001193856.1",
      "exons": [
        {
          "start": 38715311,
          "end": 38715415
        },
        {
          "start": 38722776,
          "end": 38723199
        },
        {
          "start": 38723337,
          "end": 38723471
        },
        {
          "start": 38729902,
          "end": 38729986
        },
        {
          "start": 38734474,
          "end": 38734625
        },
        {
          "start": 38737067,
          "end": 38737256
        },
        {
          "start": 38737809,
          "end": 38737972
        },
        {
          "start": 38741711,
          "end": 38741887
        },
        {
          "start": 38750476,
          "end": 38750589
        },
        {
          "start": 38755972,
          "end": 38756079
        },
        {
          "start": 38761702,
          "end": 38761803
        },
        {
          "start": 38770413,
          "end": 38770559
        },
        {
          "start": 38775754,
          "end": 38775951
        },
        {
          "start": 38778388,
          "end": 38778464
        },
        {
          "start": 38779966,
          "end": 38780065
        },
        {
          "start": 38781254,
          "end": 38781373
        },
        {
          "start": 38783004,
          "end": 38783139
        },
        {
          "start": 38786765,
          "end": 38786952
        },
        {
          "start": 38789803,
          "end": 38789883
        },
        {
          "start": 38790289,
          "end": 38790405
        },
        {
          "start": 38791555,
          "end": 38791674
        },
        {
          "start": 38803179,
          "end": 38803311
        },
        {
          "start": 38805481,
          "end": 38805596
        },
        {
          "start": 38807610,
          "end": 38807716
        },
        {
          "start": 38814054,
          "end": 38814129
        },
        {
          "start": 38815468,
          "end": 38815657
        },
        {
          "start": 38822838,
          "end": 38823034
        },
        {
          "start": 38823562,
          "end": 38823688
        },
        {
          "start": 38826156,
          "end": 38826391
        },
        {
          "start": 38828184,
          "end": 38828288
        },
        {
          "start": 38832322,
          "end": 38832435
        },
        {
          "start": 38834579,
          "end": 38834641
        },
        {
          "start": 38837942,
          "end": 38838042
        },
        {
          "start": 38842368,
          "end": 38842505
        },
        {
          "start": 38842663,
          "end": 38842903
        },
        {
          "start": 38845574,
          "end": 38845773
        },
        {
          "start": 38848648,
          "end": 38848801
        },
        {
          "start": 38850251,
          "end": 38850414
        },
        {
          "start": 38851572,
          "end": 38851674
        },
        {
          "start": 38852694,
          "end": 38852798
        },
        {
          "start": 38853186,
          "end": 38853347
        },
        {
          "start": 38857518,
          "end": 38857742
        },
        {
          "start": 38860457,
          "end": 38860629
        },
        {
          "start": 38862280,
          "end": 38862458
        },
        {
          "start": 38863873,
          "end": 38864060
        },
        {
          "start": 38866591,
          "end": 38866677
        },
        {
          "start": 38866769,
          "end": 38866876
        },
        {
          "start": 38868062,
          "end": 38868196
        },
        {
          "start": 38870401,
          "end": 38870562
        },
        {
          "start": 38872536,
          "end": 38872782
        },
        {
          "start": 38872906,
          "end": 38873147
        },
        {
          "start": 38873236,
          "end": 38873376
        },
        {
          "start": 38875591,
          "end": 38875828
        },
        {
          "start": 38882910,
          "end": 38883052
        },
        {
          "start": 38883322,
          "end": 38883456
        },
        {
          "start": 38883876,
          "end": 38883998
        },
        {
          "start": 38886791,
          "end": 38887004
        },
        {
          "start": 38890652,
          "end": 38890761
        },
        {
          "start": 38894701,
          "end": 38894864
        },
        {
          "start": 38896033,
          "end": 38896225
        },
        {
          "start": 38898258,
          "end": 38898380
        },
        {
          "start": 38899776,
          "end": 38899906
        },
        {
          "start": 38906254,
          "end": 38906407
        },
        {
          "start": 38907956,
          "end": 38908120
        },
        {
          "start": 38909518,
          "end": 38909744
        },
        {
          "start": 38911468,
          "end": 38911586
        },
        {
          "start": 38913849,
          "end": 38913952
        },
        {
          "start": 38915201,
          "end": 38915377
        },
        {
          "start": 38917239,
          "end": 38917406
        },
        {
          "start": 38917925,
          "end": 38918140
        },
        {
          "start": 38921369,
          "end": 38921506
        },
        {
          "start": 38923058,
          "end": 38923185
        },
        {
          "start": 38923991,
          "end": 38924162
        },
        {
          "start": 38926055,
          "end": 38926210
        },
        {
          "start": 38929511,
          "end": 38929666
        },
        {
          "start": 38931811,
          "end": 38931993
        },
        {
          "start": 38935592,
          "end": 38935697
        },
        {
          "start": 38937974,
          "end": 38938226
        },
        {
          "start": 38938798,
          "end": 38938988
        },
        {
          "start": 38945467,
          "end": 38945588
        },
        {
          "start": 38949452,
          "end": 38949570
        },
        {
          "start": 38951318,
          "end": 38951520
        },
        {
          "start": 38971592,
          "end": 38971665
        },
        {
          "start": 38973661,
          "end": 38973813
        },
        {
          "start": 38974374,
          "end": 38974529
        },
        {
          "start": 38982346,
          "end": 38982462
        },
        {
          "start": 38984206,
          "end": 38984307
        },
        {
          "start": 38990012,
          "end": 38990172
        },
        {
          "start": 39008814,
          "end": 39008970
        },
        {
          "start": 39012215,
          "end": 39012367
        },
        {
          "start": 39012448,
          "end": 39012637
        },
        {
          "start": 39026546,
          "end": 39026667
        },
        {
          "start": 39030105,
          "end": 39030792
        }
      ],
      "cds": {
        "start": 38722810,
        "end": 39030392
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "6",
      "start": 38683117,
      "end": 38998301,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 38373052,
      "end": 39373051,
      "genes": [
        {
          "symbol": "BTBD9",
          "ensemblId": "ENSG00000183826",
          "biotype": "protein_coding",
          "start": 38168451,
          "end": 38640172,
          "strand": "-",
          "slug": "btbd9"
        },
        {
          "symbol": "GLO1",
          "ensemblId": "ENSG00000124767",
          "biotype": "protein_coding",
          "start": 38675925,
          "end": 38703178,
          "strand": "-",
          "slug": "glo1"
        },
        {
          "symbol": "GLP1R",
          "ensemblId": "ENSG00000112164",
          "biotype": "protein_coding",
          "start": 39048562,
          "end": 39091303,
          "strand": "+",
          "slug": "glp1r"
        },
        {
          "symbol": "SAYSD1",
          "ensemblId": "ENSG00000112167",
          "biotype": "protein_coding",
          "start": 39104063,
          "end": 39115193,
          "strand": "-",
          "slug": "saysd1"
        },
        {
          "symbol": "KCNK5",
          "ensemblId": "ENSG00000164626",
          "biotype": "protein_coding",
          "start": 39183923,
          "end": 39229559,
          "strand": "-",
          "slug": "kcnk5"
        },
        {
          "symbol": "KCNK17",
          "ensemblId": "ENSG00000124780",
          "biotype": "protein_coding",
          "start": 39298998,
          "end": 39314461,
          "strand": "-",
          "slug": "kcnk17"
        },
        {
          "symbol": "KCNK16",
          "ensemblId": "ENSG00000095981",
          "biotype": "protein_coding",
          "start": 39314698,
          "end": 39322968,
          "strand": "-",
          "slug": "kcnk16"
        },
        {
          "symbol": "KIF6",
          "ensemblId": "ENSG00000164627",
          "biotype": "protein_coding",
          "start": 39329990,
          "end": 39725441,
          "strand": "-",
          "slug": "kif6"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "male-infertility",
        "name": "Erkek İnfertilitesi",
        "diseases": [
          {
            "mondoId": "MONDO:0005372",
            "name": "Erkek İnfertilitesi",
            "genes": 41,
            "inheritance": null,
            "description": "Belirli bir süre korunmasız cinsel ilişkiye rağmen erkeğin bir yumurta hücresini döllendirememesi. Erkek steriliteti kalıcı infertilitedir.",
            "management": null,
            "evidence": {
              "gencc": [
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Strong",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/tr/conditions/male-infertility"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "absent-sperm-flagella",
        "name": "Absent sperm flagella",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/absent-sperm-flagella"
      },
      {
        "slug": "coiled-sperm-flagella",
        "name": "Coiled sperm flagella",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/coiled-sperm-flagella"
      },
      {
        "slug": "irregularly-shaped-sperm-tail",
        "name": "Irregularly shaped sperm tail",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/irregularly-shaped-sperm-tail"
      },
      {
        "slug": "male-infertility",
        "name": "Male infertility",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/male-infertility"
      },
      {
        "slug": "reduced-sperm-motility",
        "name": "Reduced sperm motility",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/reduced-sperm-motility"
      },
      {
        "slug": "short-sperm-flagella",
        "name": "Short sperm flagella",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/short-sperm-flagella"
      }
    ],
    "related": [
      {
        "slug": "actl9",
        "symbol": "ACTL9",
        "name": "actin like 9",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/actl9"
      },
      {
        "slug": "armc2",
        "symbol": "ARMC2",
        "name": "armadillo repeat containing 2",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/armc2"
      },
      {
        "slug": "aurkc",
        "symbol": "AURKC",
        "name": "aurora kinase C",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/aurkc"
      },
      {
        "slug": "bcorl1",
        "symbol": "BCORL1",
        "name": "BCL6 corepressor like 1",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/bcorl1"
      },
      {
        "slug": "cfap251",
        "symbol": "CFAP251",
        "name": "cilia and flagella associated protein 251",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/cfap251"
      },
      {
        "slug": "cfap43",
        "symbol": "CFAP43",
        "name": "cilia and flagella associated protein 43",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/cfap43"
      },
      {
        "slug": "dmc1",
        "symbol": "DMC1",
        "name": "DNA meiotic recombinase 1",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/dmc1"
      },
      {
        "slug": "dmrt1",
        "symbol": "DMRT1",
        "name": "doublesex and mab-3 related transcription factor 1",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/dmrt1"
      },
      {
        "slug": "dnah1",
        "symbol": "DNAH1",
        "name": "dynein axonemal heavy chain 1",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/dnah1"
      },
      {
        "slug": "dnah10",
        "symbol": "DNAH10",
        "name": "dynein axonemal heavy chain 10",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/dnah10"
      },
      {
        "slug": "dnah12",
        "symbol": "DNAH12",
        "name": "dynein axonemal heavy chain 12",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/dnah12"
      },
      {
        "slug": "dnah17",
        "symbol": "DNAH17",
        "name": "dynein axonemal heavy chain 17",
        "shared": 1,
        "url": "https://dantelabs.com/tr/genes/dnah17"
      }
    ],
    "sources": {
      "bundleId": "2026.10.16-c6eea6bf",
      "panel": "2026-10-16",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}