{
  "url": "https://dantelabs.com/traits/polyuria",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "polyuria",
    "id": "HP:0000103",
    "name": "Increased urine output",
    "label": "Polyuria",
    "definition": "An increased rate of urine production.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-urine-output",
        "name": "Abnormal urine output",
        "url": "https://dantelabs.com/traits/abnormal-urine-output"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "aqp2",
        "symbol": "AQP2",
        "hgnc": "HGNC:634",
        "name": "aquaporin 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aqp2"
      },
      {
        "slug": "avpr2",
        "symbol": "AVPR2",
        "hgnc": "HGNC:897",
        "name": "arginine vasopressin receptor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/avpr2"
      },
      {
        "slug": "bbs2",
        "symbol": "BBS2",
        "hgnc": "HGNC:967",
        "name": "Bardet-Biedl syndrome 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bbs2"
      },
      {
        "slug": "bsnd",
        "symbol": "BSND",
        "hgnc": "HGNC:16512",
        "name": "barttin CLCNK type accessory subunit beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bsnd"
      },
      {
        "slug": "cilk1",
        "symbol": "CILK1",
        "hgnc": "HGNC:21219",
        "name": "ciliogenesis associated kinase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cilk1"
      },
      {
        "slug": "lztfl1",
        "symbol": "LZTFL1",
        "hgnc": "HGNC:6741",
        "name": "leucine zipper transcription factor like 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lztfl1"
      },
      {
        "slug": "nek8",
        "symbol": "NEK8",
        "hgnc": "HGNC:13387",
        "name": "NIMA related kinase 8",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nek8"
      },
      {
        "slug": "pax4",
        "symbol": "PAX4",
        "hgnc": "HGNC:8618",
        "name": "paired box 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax4"
      },
      {
        "slug": "sars2",
        "symbol": "SARS2",
        "hgnc": "HGNC:17697",
        "name": "seryl-tRNA synthetase 2, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sars2"
      },
      {
        "slug": "slc41a1",
        "symbol": "SLC41A1",
        "hgnc": "HGNC:19429",
        "name": "solute carrier family 41 member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc41a1"
      },
      {
        "slug": "son",
        "symbol": "SON",
        "hgnc": "HGNC:11183",
        "name": "SON DNA and RNA binding protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/son"
      },
      {
        "slug": "cldn16",
        "symbol": "CLDN16",
        "hgnc": "HGNC:2037",
        "name": "claudin 16",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cldn16"
      },
      {
        "slug": "atp1a1",
        "symbol": "ATP1A1",
        "hgnc": "HGNC:799",
        "name": "ATPase Na+/K+ transporting subunit alpha 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp1a1"
      },
      {
        "slug": "cav1",
        "symbol": "CAV1",
        "hgnc": "HGNC:1527",
        "name": "caveolin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cav1"
      },
      {
        "slug": "ctns",
        "symbol": "CTNS",
        "hgnc": "HGNC:2518",
        "name": "cystinosin, lysosomal cystine transporter",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctns"
      },
      {
        "slug": "cyp24a1",
        "symbol": "CYP24A1",
        "hgnc": "HGNC:2602",
        "name": "cytochrome P450 family 24 subfamily A member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp24a1"
      },
      {
        "slug": "nphp1",
        "symbol": "NPHP1",
        "hgnc": "HGNC:7905",
        "name": "nephrocystin 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nphp1"
      },
      {
        "slug": "nphp3",
        "symbol": "NPHP3",
        "hgnc": "HGNC:7907",
        "name": "nephrocystin 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nphp3"
      },
      {
        "slug": "rragd",
        "symbol": "RRAGD",
        "hgnc": "HGNC:19903",
        "name": "Ras related GTP binding D",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rragd"
      },
      {
        "slug": "slc34a1",
        "symbol": "SLC34A1",
        "hgnc": "HGNC:11019",
        "name": "solute carrier family 34 member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc34a1"
      },
      {
        "slug": "umod",
        "symbol": "UMOD",
        "hgnc": "HGNC:12559",
        "name": "uromodulin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/umod"
      },
      {
        "slug": "fbxo22",
        "symbol": "FBXO22",
        "hgnc": "HGNC:13593",
        "name": "F-box protein 22",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo22"
      },
      {
        "slug": "kcnj5",
        "symbol": "KCNJ5",
        "hgnc": "HGNC:6266",
        "name": "potassium inwardly rectifying channel subfamily J member 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj5"
      },
      {
        "slug": "casr",
        "symbol": "CASR",
        "hgnc": "HGNC:1514",
        "name": "calcium sensing receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/casr"
      },
      {
        "slug": "clcnka",
        "symbol": "CLCNKA",
        "hgnc": "HGNC:2026",
        "name": "chloride voltage-gated channel Ka",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clcnka"
      },
      {
        "slug": "clcnkb",
        "symbol": "CLCNKB",
        "hgnc": "HGNC:2027",
        "name": "chloride voltage-gated channel Kb",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/clcnkb"
      },
      {
        "slug": "cldn10",
        "symbol": "CLDN10",
        "hgnc": "HGNC:2033",
        "name": "claudin 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cldn10"
      },
      {
        "slug": "fam20a",
        "symbol": "FAM20A",
        "hgnc": "HGNC:23015",
        "name": "FAM20A golgi associated secretory pathway pseudokinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fam20a"
      },
      {
        "slug": "hnf1a",
        "symbol": "HNF1A",
        "hgnc": "HGNC:11621",
        "name": "HNF1 homeobox A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnf1a"
      },
      {
        "slug": "il6",
        "symbol": "IL6",
        "hgnc": "HGNC:6018",
        "name": "interleukin 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il6"
      },
      {
        "slug": "kcnj1",
        "symbol": "KCNJ1",
        "hgnc": "HGNC:6255",
        "name": "potassium inwardly rectifying channel subfamily J member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj1"
      },
      {
        "slug": "kcnj10",
        "symbol": "KCNJ10",
        "hgnc": "HGNC:6256",
        "name": "potassium inwardly rectifying channel subfamily J member 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj10"
      },
      {
        "slug": "maged2",
        "symbol": "MAGED2",
        "hgnc": "HGNC:16353",
        "name": "MAGE family member D2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/maged2"
      },
      {
        "slug": "nphp4",
        "symbol": "NPHP4",
        "hgnc": "HGNC:19104",
        "name": "nephrocystin 4",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nphp4"
      },
      {
        "slug": "plvap",
        "symbol": "PLVAP",
        "hgnc": "HGNC:13635",
        "name": "plasmalemma vesicle associated protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plvap"
      },
      {
        "slug": "slc12a1",
        "symbol": "SLC12A1",
        "hgnc": "HGNC:10910",
        "name": "solute carrier family 12 member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc12a1"
      },
      {
        "slug": "slc12a3",
        "symbol": "SLC12A3",
        "hgnc": "HGNC:10912",
        "name": "solute carrier family 12 member 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc12a3"
      },
      {
        "slug": "slc5a2",
        "symbol": "SLC5A2",
        "hgnc": "HGNC:11037",
        "name": "solute carrier family 5 member 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc5a2"
      },
      {
        "slug": "tmem67",
        "symbol": "TMEM67",
        "hgnc": "HGNC:28396",
        "name": "transmembrane protein 67",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem67"
      }
    ]
  }
}