{
  "url": "https://dantelabs.com/traits/microglossia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "microglossia",
    "id": "HP:0000171",
    "name": "Abnormally small tongue",
    "label": "Microglossia",
    "definition": "Decreased length and width of the tongue.",
    "synonyms": [
      "Underdevelopment of the tongue",
      "Decreased size of tongue",
      "Hypoglossia",
      "Hypoplasia of the tongue",
      "Hypoplastic tongue",
      "Lingual hypoplasia",
      "Rudimentary tongue",
      "Small tongue"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "aplasia-hypoplasia-of-the-tongue",
        "name": "Aplasia/Hypoplasia of the tongue",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-tongue"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "prrx1",
        "symbol": "PRRX1",
        "hgnc": "HGNC:9142",
        "name": "paired related homeobox 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/prrx1"
      },
      {
        "slug": "rbbp8",
        "symbol": "RBBP8",
        "hgnc": "HGNC:9891",
        "name": "RB binding protein 8, endonuclease",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbbp8"
      },
      {
        "slug": "otx2",
        "symbol": "OTX2",
        "hgnc": "HGNC:8522",
        "name": "orthodenticle homeobox 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otx2"
      },
      {
        "slug": "ecm1",
        "symbol": "ECM1",
        "hgnc": "HGNC:3153",
        "name": "extracellular matrix protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ecm1"
      },
      {
        "slug": "lmnb2",
        "symbol": "LMNB2",
        "hgnc": "HGNC:6638",
        "name": "lamin B2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmnb2"
      },
      {
        "slug": "mymk",
        "symbol": "MYMK",
        "hgnc": "HGNC:33778",
        "name": "myomaker, myoblast fusion factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mymk"
      },
      {
        "slug": "ror2",
        "symbol": "ROR2",
        "hgnc": "HGNC:10257",
        "name": "ROR family WNT receptor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ror2"
      },
      {
        "slug": "dhcr7",
        "symbol": "DHCR7",
        "hgnc": "HGNC:2860",
        "name": "7-dehydrocholesterol reductase",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dhcr7"
      },
      {
        "slug": "edn1",
        "symbol": "EDN1",
        "hgnc": "HGNC:3176",
        "name": "endothelin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/edn1"
      },
      {
        "slug": "gli3",
        "symbol": "GLI3",
        "hgnc": "HGNC:4319",
        "name": "GLI family zinc finger 3",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gli3"
      },
      {
        "slug": "gnai3",
        "symbol": "GNAI3",
        "hgnc": "HGNC:4387",
        "name": "G protein subunit alpha i3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnai3"
      },
      {
        "slug": "nek1",
        "symbol": "NEK1",
        "hgnc": "HGNC:7744",
        "name": "NIMA related kinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek1"
      },
      {
        "slug": "plcb4",
        "symbol": "PLCB4",
        "hgnc": "HGNC:9059",
        "name": "phospholipase C beta 4",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/plcb4"
      },
      {
        "slug": "bmp4",
        "symbol": "BMP4",
        "hgnc": "HGNC:1071",
        "name": "bone morphogenetic protein 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmp4"
      },
      {
        "slug": "ptdss1",
        "symbol": "PTDSS1",
        "hgnc": "HGNC:9587",
        "name": "phosphatidylserine synthase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptdss1"
      },
      {
        "slug": "smo",
        "symbol": "SMO",
        "hgnc": "HGNC:11119",
        "name": "smoothened, frizzled class receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smo"
      },
      {
        "slug": "tbx15",
        "symbol": "TBX15",
        "hgnc": "HGNC:11594",
        "name": "T-box transcription factor 15",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx15"
      },
      {
        "slug": "trim37",
        "symbol": "TRIM37",
        "hgnc": "HGNC:7523",
        "name": "tripartite motif containing 37",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trim37"
      }
    ]
  }
}