{
  "url": "https://dantelabs.com/traits/knee-contracture",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "knee-contracture",
    "id": "HP:0034671",
    "name": "Knee contracture",
    "definition": "Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of the knee joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin.",
    "synonyms": [
      "Contracture of knee",
      "Contracture of the knees",
      "Knee contractures"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-knee-morphology",
        "name": "Abnormal knee morphology",
        "url": "https://dantelabs.com/traits/abnormal-knee-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "knee-flexion-contracture",
        "name": "Inability to straighten knee",
        "genes": 109,
        "url": "https://dantelabs.com/traits/knee-flexion-contracture"
      },
      {
        "slug": "knee-extension-contracture",
        "name": "Knee extension contracture",
        "genes": 1,
        "url": "https://dantelabs.com/traits/knee-extension-contracture"
      }
    ],
    "genes": [
      {
        "slug": "gnpat",
        "symbol": "GNPAT",
        "hgnc": "HGNC:4416",
        "name": "glyceronephosphate O-acyltransferase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnpat"
      },
      {
        "slug": "gtpbp2",
        "symbol": "GTPBP2",
        "hgnc": "HGNC:4670",
        "name": "GTP binding protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtpbp2"
      },
      {
        "slug": "ndc1",
        "symbol": "NDC1",
        "hgnc": "HGNC:25525",
        "name": "NDC1 transmembrane nucleoporin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndc1"
      },
      {
        "slug": "unc13a",
        "symbol": "UNC13A",
        "hgnc": "HGNC:23150",
        "name": "unc-13 homolog A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc13a"
      },
      {
        "slug": "col6a2",
        "symbol": "COL6A2",
        "hgnc": "HGNC:2212",
        "name": "collagen type VI alpha 2 chain",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/col6a2"
      },
      {
        "slug": "col6a3",
        "symbol": "COL6A3",
        "hgnc": "HGNC:2213",
        "name": "collagen type VI alpha 3 chain",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col6a3"
      },
      {
        "slug": "acta1",
        "symbol": "ACTA1",
        "hgnc": "HGNC:129",
        "name": "actin alpha 1, skeletal muscle",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acta1"
      },
      {
        "slug": "borcs8",
        "symbol": "BORCS8",
        "hgnc": "HGNC:37247",
        "name": "BLOC-1 related complex subunit 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/borcs8"
      },
      {
        "slug": "cfl2",
        "symbol": "CFL2",
        "hgnc": "HGNC:1875",
        "name": "cofilin 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfl2"
      },
      {
        "slug": "cox11",
        "symbol": "COX11",
        "hgnc": "HGNC:2261",
        "name": "cytochrome c oxidase copper chaperone COX11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox11"
      },
      {
        "slug": "dhrsx",
        "symbol": "DHRSX",
        "hgnc": "HGNC:18399",
        "name": "dehydrogenase/reductase X-linked",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhrsx"
      },
      {
        "slug": "epg5",
        "symbol": "EPG5",
        "hgnc": "HGNC:29331",
        "name": "ectopic P-granules 5 autophagy tethering factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epg5"
      },
      {
        "slug": "fbn2",
        "symbol": "FBN2",
        "hgnc": "HGNC:3604",
        "name": "fibrillin 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbn2"
      },
      {
        "slug": "filip1",
        "symbol": "FILIP1",
        "hgnc": "HGNC:21015",
        "name": "filamin A interacting protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/filip1"
      },
      {
        "slug": "megf10",
        "symbol": "MEGF10",
        "hgnc": "HGNC:29634",
        "name": "multiple EGF like domains 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/megf10"
      },
      {
        "slug": "uggt1",
        "symbol": "UGGT1",
        "hgnc": "HGNC:15663",
        "name": "UDP-glucose glycoprotein glucosyltransferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uggt1"
      },
      {
        "slug": "itpr3",
        "symbol": "ITPR3",
        "hgnc": "HGNC:6182",
        "name": "inositol 1,4,5-trisphosphate receptor type 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itpr3"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "scarf2",
        "symbol": "SCARF2",
        "hgnc": "HGNC:19869",
        "name": "scavenger receptor class F member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scarf2"
      },
      {
        "slug": "scn4a",
        "symbol": "SCN4A",
        "hgnc": "HGNC:10591",
        "name": "sodium voltage-gated channel alpha subunit 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn4a"
      }
    ]
  }
}