{
  "url": "https://dantelabs.com/traits/increased-inflammatory-response",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "increased-inflammatory-response",
    "id": "HP:0012649",
    "name": "Increased inflammatory response",
    "definition": "A abnormal increase in the inflammatory response to injury or infection.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-inflammatory-response",
        "name": "Abnormal inflammatory response",
        "url": "https://dantelabs.com/traits/abnormal-inflammatory-response"
      }
    ],
    "narrower": [
      {
        "slug": "pneumonia",
        "name": "Pneumonia",
        "genes": 114,
        "url": "https://dantelabs.com/traits/pneumonia"
      },
      {
        "slug": "pancreatitis",
        "name": "Pancreatic inflammation",
        "genes": 76,
        "url": "https://dantelabs.com/traits/pancreatitis"
      },
      {
        "slug": "otitis-media",
        "name": "Middle ear infection",
        "genes": 74,
        "url": "https://dantelabs.com/traits/otitis-media"
      },
      {
        "slug": "hepatitis",
        "name": "Liver inflammation",
        "genes": 71,
        "url": "https://dantelabs.com/traits/hepatitis"
      },
      {
        "slug": "sinusitis",
        "name": "Sinus disease",
        "genes": 71,
        "url": "https://dantelabs.com/traits/sinusitis"
      },
      {
        "slug": "osteomyelitis",
        "name": "Bone infection",
        "genes": 67,
        "url": "https://dantelabs.com/traits/osteomyelitis"
      },
      {
        "slug": "myositis",
        "name": "Muscle inflammation",
        "genes": 46,
        "url": "https://dantelabs.com/traits/myositis"
      },
      {
        "slug": "periodontitis",
        "name": "Gum disease",
        "genes": 38,
        "url": "https://dantelabs.com/traits/periodontitis"
      },
      {
        "slug": "thyroiditis",
        "name": "Thyroid gland inflammation",
        "genes": 38,
        "url": "https://dantelabs.com/traits/thyroiditis"
      },
      {
        "slug": "serositis",
        "name": "Serositis",
        "genes": 31,
        "url": "https://dantelabs.com/traits/serositis"
      },
      {
        "slug": "stomatitis",
        "name": "Inflammation of the mouth",
        "genes": 30,
        "url": "https://dantelabs.com/traits/stomatitis"
      },
      {
        "slug": "panniculitis",
        "name": "Inflammation of fat tissue",
        "genes": 28,
        "url": "https://dantelabs.com/traits/panniculitis"
      },
      {
        "slug": "nephritis",
        "name": "Kidney inflammation",
        "genes": 24,
        "url": "https://dantelabs.com/traits/nephritis"
      },
      {
        "slug": "epididymitis",
        "name": "Epididymitis",
        "genes": 21,
        "url": "https://dantelabs.com/traits/epididymitis"
      },
      {
        "slug": "cholangitis",
        "name": "Bile duct inflammation",
        "genes": 20,
        "url": "https://dantelabs.com/traits/cholangitis"
      },
      {
        "slug": "lymphadenitis",
        "name": "Inflammation of the lymph nodes",
        "genes": 20,
        "url": "https://dantelabs.com/traits/lymphadenitis"
      },
      {
        "slug": "endocarditis",
        "name": "Endocarditis",
        "genes": 17,
        "url": "https://dantelabs.com/traits/endocarditis"
      },
      {
        "slug": "inflammatory-abnormality-of-the-eye",
        "name": "Inflammatory abnormality of the eye",
        "genes": 16,
        "url": "https://dantelabs.com/traits/inflammatory-abnormality-of-the-eye"
      },
      {
        "slug": "gastrointestinal-inflammation",
        "name": "Gastrointestinal inflammation",
        "genes": 14,
        "url": "https://dantelabs.com/traits/gastrointestinal-inflammation"
      },
      {
        "slug": "inflammatory-abnormality-of-the-skin",
        "name": "Inflammatory abnormality of the skin",
        "genes": 13,
        "url": "https://dantelabs.com/traits/inflammatory-abnormality-of-the-skin"
      },
      {
        "slug": "prostatitis",
        "name": "Inflammation of the prostate",
        "genes": 7,
        "url": "https://dantelabs.com/traits/prostatitis"
      },
      {
        "slug": "fasciitis",
        "name": "Inflammation of the fascia",
        "genes": 3,
        "url": "https://dantelabs.com/traits/fasciitis"
      },
      {
        "slug": "urinary-bladder-inflammation",
        "name": "Urinary bladder inflammation",
        "genes": 2,
        "url": "https://dantelabs.com/traits/urinary-bladder-inflammation"
      },
      {
        "slug": "recurrent-bacterial-vaginosis",
        "name": "Recurrent bacterial vaginosis",
        "genes": 1,
        "url": "https://dantelabs.com/traits/recurrent-bacterial-vaginosis"
      },
      {
        "slug": "chondritis",
        "name": "Cartilage inflammation",
        "genes": 0,
        "url": "https://dantelabs.com/traits/chondritis"
      },
      {
        "slug": "neuroinflammation",
        "name": "Neuroinflammation",
        "genes": 0,
        "url": "https://dantelabs.com/traits/neuroinflammation"
      }
    ],
    "genes": [
      {
        "slug": "c4a",
        "symbol": "C4A",
        "hgnc": "HGNC:1323",
        "name": "complement C4A (Chido/Rodgers blood group)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c4a"
      },
      {
        "slug": "ccr1",
        "symbol": "CCR1",
        "hgnc": "HGNC:1602",
        "name": "C-C motif chemokine receptor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccr1"
      },
      {
        "slug": "ctla4",
        "symbol": "CTLA4",
        "hgnc": "HGNC:2505",
        "name": "cytotoxic T-lymphocyte associated protein 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctla4"
      },
      {
        "slug": "erap1",
        "symbol": "ERAP1",
        "hgnc": "HGNC:18173",
        "name": "endoplasmic reticulum aminopeptidase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erap1"
      },
      {
        "slug": "fas",
        "symbol": "FAS",
        "hgnc": "HGNC:11920",
        "name": "Fas cell surface death receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fas"
      },
      {
        "slug": "hla-b",
        "symbol": "HLA-B",
        "hgnc": "HGNC:4932",
        "name": "major histocompatibility complex, class I, B",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hla-b"
      },
      {
        "slug": "hla-dpa1",
        "symbol": "HLA-DPA1",
        "hgnc": "HGNC:4938",
        "name": "major histocompatibility complex, class II, DP alpha 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-dpa1"
      },
      {
        "slug": "hla-dpb1",
        "symbol": "HLA-DPB1",
        "hgnc": "HGNC:4940",
        "name": "major histocompatibility complex, class II, DP beta 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-dpb1"
      },
      {
        "slug": "ifngr1",
        "symbol": "IFNGR1",
        "hgnc": "HGNC:5439",
        "name": "interferon gamma receptor 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ifngr1"
      },
      {
        "slug": "il10",
        "symbol": "IL10",
        "hgnc": "HGNC:5962",
        "name": "interleukin 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il10"
      },
      {
        "slug": "il12a",
        "symbol": "IL12A",
        "hgnc": "HGNC:5969",
        "name": "interleukin 12A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il12a"
      },
      {
        "slug": "il12a-as1",
        "symbol": "IL12A-AS1",
        "hgnc": "HGNC:49094",
        "name": "IL12A antisense RNA 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il12a-as1"
      },
      {
        "slug": "il12b",
        "symbol": "IL12B",
        "hgnc": "HGNC:5970",
        "name": "interleukin 12B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il12b"
      },
      {
        "slug": "il23r",
        "symbol": "IL23R",
        "hgnc": "HGNC:19100",
        "name": "interleukin 23 receptor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il23r"
      },
      {
        "slug": "klrc4",
        "symbol": "KLRC4",
        "hgnc": "HGNC:6377",
        "name": "killer cell lectin like receptor C4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klrc4"
      },
      {
        "slug": "mefv",
        "symbol": "MEFV",
        "hgnc": "HGNC:6998",
        "name": "MEFV innate immunity regulator, pyrin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mefv"
      },
      {
        "slug": "mlx",
        "symbol": "MLX",
        "hgnc": "HGNC:11645",
        "name": "MAX dimerization protein MLX",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mlx"
      },
      {
        "slug": "prtn3",
        "symbol": "PRTN3",
        "hgnc": "HGNC:9495",
        "name": "proteinase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prtn3"
      },
      {
        "slug": "ptpn22",
        "symbol": "PTPN22",
        "hgnc": "HGNC:9652",
        "name": "protein tyrosine phosphatase non-receptor type 22",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn22"
      },
      {
        "slug": "stat4",
        "symbol": "STAT4",
        "hgnc": "HGNC:11365",
        "name": "signal transducer and activator of transcription 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat4"
      },
      {
        "slug": "tlr4",
        "symbol": "TLR4",
        "hgnc": "HGNC:11850",
        "name": "toll like receptor 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tlr4"
      },
      {
        "slug": "ubac2",
        "symbol": "UBAC2",
        "hgnc": "HGNC:20486",
        "name": "UBA domain containing 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubac2"
      },
      {
        "slug": "ankh",
        "symbol": "ANKH",
        "hgnc": "HGNC:15492",
        "name": "ANKH inorganic pyrophosphate transport regulator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ankh"
      },
      {
        "slug": "pstpip1",
        "symbol": "PSTPIP1",
        "hgnc": "HGNC:9580",
        "name": "proline-serine-threonine phosphatase interacting protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pstpip1"
      },
      {
        "slug": "tnfrsf11b",
        "symbol": "TNFRSF11B",
        "hgnc": "HGNC:11909",
        "name": "TNF receptor superfamily member 11b",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf11b"
      },
      {
        "slug": "trappc2",
        "symbol": "TRAPPC2",
        "hgnc": "HGNC:23068",
        "name": "trafficking protein particle complex subunit 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trappc2"
      }
    ]
  }
}