{
  "url": "https://dantelabs.com/traits/immunodeficiency",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "immunodeficiency",
    "id": "HP:0002721",
    "name": "Decreased immune function",
    "label": "Immunodeficiency",
    "definition": "Failure of the immune system to protect the body adequately from infection, due to the absence or insufficiency of some component process or substance.",
    "synonyms": [
      "Immune deficiency"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-immune-system-physiology",
        "name": "Abnormality of immune system physiology",
        "url": "https://dantelabs.com/traits/abnormality-of-immune-system-physiology"
      }
    ],
    "narrower": [
      {
        "slug": "cellular-immunodeficiency",
        "name": "Cellular immunodeficiency",
        "genes": 29,
        "url": "https://dantelabs.com/traits/cellular-immunodeficiency"
      },
      {
        "slug": "combined-immunodeficiency",
        "name": "Combined immunodeficiency",
        "genes": 26,
        "url": "https://dantelabs.com/traits/combined-immunodeficiency"
      },
      {
        "slug": "humoral-immunodeficiency",
        "name": "Humoral immunodeficiency",
        "genes": 4,
        "url": "https://dantelabs.com/traits/humoral-immunodeficiency"
      }
    ],
    "genes": [
      {
        "slug": "ak2",
        "symbol": "AK2",
        "hgnc": "HGNC:362",
        "name": "adenylate kinase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ak2"
      },
      {
        "slug": "ap3d1",
        "symbol": "AP3D1",
        "hgnc": "HGNC:568",
        "name": "adaptor related protein complex 3 subunit delta 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap3d1"
      },
      {
        "slug": "arpc5",
        "symbol": "ARPC5",
        "hgnc": "HGNC:708",
        "name": "actin related protein 2/3 complex subunit 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arpc5"
      },
      {
        "slug": "card11",
        "symbol": "CARD11",
        "hgnc": "HGNC:16393",
        "name": "caspase recruitment domain family member 11",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/card11"
      },
      {
        "slug": "cd3e",
        "symbol": "CD3E",
        "hgnc": "HGNC:1674",
        "name": "CD3 epsilon subunit of T-cell receptor complex",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd3e"
      },
      {
        "slug": "coro1a",
        "symbol": "CORO1A",
        "hgnc": "HGNC:2252",
        "name": "coronin 1A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coro1a"
      },
      {
        "slug": "dclre1b",
        "symbol": "DCLRE1B",
        "hgnc": "HGNC:17641",
        "name": "DNA cross-link repair 1B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dclre1b"
      },
      {
        "slug": "dclre1c",
        "symbol": "DCLRE1C",
        "hgnc": "HGNC:17642",
        "name": "DNA cross-link repair 1C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dclre1c"
      },
      {
        "slug": "dpp9",
        "symbol": "DPP9",
        "hgnc": "HGNC:18648",
        "name": "dipeptidyl peptidase 9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpp9"
      },
      {
        "slug": "gata2",
        "symbol": "GATA2",
        "hgnc": "HGNC:4171",
        "name": "GATA binding protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata2"
      },
      {
        "slug": "guk1",
        "symbol": "GUK1",
        "hgnc": "HGNC:4693",
        "name": "guanylate kinase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/guk1"
      },
      {
        "slug": "hyou1",
        "symbol": "HYOU1",
        "hgnc": "HGNC:16931",
        "name": "hypoxia up-regulated 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hyou1"
      },
      {
        "slug": "ikbkg",
        "symbol": "IKBKG",
        "hgnc": "HGNC:5961",
        "name": "inhibitor of nuclear factor kappa B kinase regulatory subunit gamma",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ikbkg"
      },
      {
        "slug": "ikzf2",
        "symbol": "IKZF2",
        "hgnc": "HGNC:13177",
        "name": "IKAROS family zinc finger 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ikzf2"
      },
      {
        "slug": "itpr3",
        "symbol": "ITPR3",
        "hgnc": "HGNC:6182",
        "name": "inositol 1,4,5-trisphosphate receptor type 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itpr3"
      },
      {
        "slug": "lck",
        "symbol": "LCK",
        "hgnc": "HGNC:6524",
        "name": "LCK proto-oncogene, Src family tyrosine kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lck"
      },
      {
        "slug": "lcp2",
        "symbol": "LCP2",
        "hgnc": "HGNC:6529",
        "name": "lymphocyte cytosolic protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lcp2"
      },
      {
        "slug": "malt1",
        "symbol": "MALT1",
        "hgnc": "HGNC:6819",
        "name": "MALT1 paracaspase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/malt1"
      },
      {
        "slug": "man2b2",
        "symbol": "MAN2B2",
        "hgnc": "HGNC:29623",
        "name": "mannosidase alpha class 2B member 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/man2b2"
      },
      {
        "slug": "mcm10",
        "symbol": "MCM10",
        "hgnc": "HGNC:18043",
        "name": "minichromosome maintenance 10 replication initiation factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mcm10"
      },
      {
        "slug": "nhej1",
        "symbol": "NHEJ1",
        "hgnc": "HGNC:25737",
        "name": "non-homologous end joining factor 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nhej1"
      },
      {
        "slug": "ptcra",
        "symbol": "PTCRA",
        "hgnc": "HGNC:21290",
        "name": "pre T cell antigen receptor alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptcra"
      },
      {
        "slug": "rag1",
        "symbol": "RAG1",
        "hgnc": "HGNC:9831",
        "name": "recombination activating 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rag1"
      },
      {
        "slug": "rag2",
        "symbol": "RAG2",
        "hgnc": "HGNC:9832",
        "name": "recombination activating 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rag2"
      },
      {
        "slug": "rnf31",
        "symbol": "RNF31",
        "hgnc": "HGNC:16031",
        "name": "ring finger protein 31",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf31"
      },
      {
        "slug": "sik3",
        "symbol": "SIK3",
        "hgnc": "HGNC:29165",
        "name": "SIK family kinase 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sik3"
      },
      {
        "slug": "slc19a1",
        "symbol": "SLC19A1",
        "hgnc": "HGNC:10937",
        "name": "solute carrier family 19 member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc19a1"
      },
      {
        "slug": "stat1",
        "symbol": "STAT1",
        "hgnc": "HGNC:11362",
        "name": "signal transducer and activator of transcription 1",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/stat1"
      },
      {
        "slug": "stim1",
        "symbol": "STIM1",
        "hgnc": "HGNC:11386",
        "name": "stromal interaction molecule 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stim1"
      },
      {
        "slug": "stk4",
        "symbol": "STK4",
        "hgnc": "HGNC:11408",
        "name": "serine/threonine kinase 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stk4"
      },
      {
        "slug": "acd",
        "symbol": "ACD",
        "hgnc": "HGNC:25070",
        "name": "ACD shelterin complex subunit and telomerase recruitment factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acd"
      },
      {
        "slug": "actb",
        "symbol": "ACTB",
        "hgnc": "HGNC:132",
        "name": "actin beta",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actb"
      },
      {
        "slug": "agl",
        "symbol": "AGL",
        "hgnc": "HGNC:321",
        "name": "amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/agl"
      },
      {
        "slug": "antxr2",
        "symbol": "ANTXR2",
        "hgnc": "HGNC:21732",
        "name": "ANTXR cell adhesion molecule 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/antxr2"
      },
      {
        "slug": "arvcf",
        "symbol": "ARVCF",
        "hgnc": "HGNC:728",
        "name": "ARVCF delta catenin family member",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arvcf"
      },
      {
        "slug": "atm",
        "symbol": "ATM",
        "hgnc": "HGNC:795",
        "name": "ATM serine/threonine kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atm"
      },
      {
        "slug": "blnk",
        "symbol": "BLNK",
        "hgnc": "HGNC:14211",
        "name": "B cell linker",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/blnk"
      },
      {
        "slug": "btk",
        "symbol": "BTK",
        "hgnc": "HGNC:1133",
        "name": "Bruton tyrosine kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/btk"
      },
      {
        "slug": "cd79a",
        "symbol": "CD79A",
        "hgnc": "HGNC:1698",
        "name": "CD79a molecule",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd79a"
      },
      {
        "slug": "cd79b",
        "symbol": "CD79B",
        "hgnc": "HGNC:1699",
        "name": "CD79b molecule",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd79b"
      },
      {
        "slug": "cdca7",
        "symbol": "CDCA7",
        "hgnc": "HGNC:14628",
        "name": "cell division cycle associated 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdca7"
      },
      {
        "slug": "comt",
        "symbol": "COMT",
        "hgnc": "HGNC:2228",
        "name": "catechol-O-methyltransferase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/comt"
      },
      {
        "slug": "dkc1",
        "symbol": "DKC1",
        "hgnc": "HGNC:2890",
        "name": "dyskerin pseudouridine synthase 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dkc1"
      },
      {
        "slug": "dnmt3b",
        "symbol": "DNMT3B",
        "hgnc": "HGNC:2979",
        "name": "DNA methyltransferase 3 beta",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dnmt3b"
      },
      {
        "slug": "foxn1",
        "symbol": "FOXN1",
        "hgnc": "HGNC:12765",
        "name": "forkhead box N1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxn1"
      },
      {
        "slug": "gp1bb",
        "symbol": "GP1BB",
        "hgnc": "HGNC:4440",
        "name": "glycoprotein Ib platelet subunit beta",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gp1bb"
      },
      {
        "slug": "hells",
        "symbol": "HELLS",
        "hgnc": "HGNC:4861",
        "name": "helicase, lymphoid specific",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hells"
      },
      {
        "slug": "hira",
        "symbol": "HIRA",
        "hgnc": "HGNC:4916",
        "name": "histone cell cycle regulator",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hira"
      },
      {
        "slug": "ighm",
        "symbol": "IGHM",
        "hgnc": "HGNC:5541",
        "name": "immunoglobulin heavy constant mu",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ighm"
      },
      {
        "slug": "igll1",
        "symbol": "IGLL1",
        "hgnc": "HGNC:5870",
        "name": "immunoglobulin lambda like polypeptide 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igll1"
      },
      {
        "slug": "il12rb1",
        "symbol": "IL12RB1",
        "hgnc": "HGNC:5971",
        "name": "interleukin 12 receptor subunit beta 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/il12rb1"
      },
      {
        "slug": "irak4",
        "symbol": "IRAK4",
        "hgnc": "HGNC:17967",
        "name": "interleukin 1 receptor associated kinase 4",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/irak4"
      },
      {
        "slug": "jmjd1c",
        "symbol": "JMJD1C",
        "hgnc": "HGNC:12313",
        "name": "jumonji domain containing 1C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jmjd1c"
      },
      {
        "slug": "lamtor2",
        "symbol": "LAMTOR2",
        "hgnc": "HGNC:29796",
        "name": "late endosomal/lysosomal adaptor, MAPK and MTOR activator 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lamtor2"
      },
      {
        "slug": "lig4",
        "symbol": "LIG4",
        "hgnc": "HGNC:6601",
        "name": "DNA ligase 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lig4"
      },
      {
        "slug": "lrrc8a",
        "symbol": "LRRC8A",
        "hgnc": "HGNC:19027",
        "name": "leucine rich repeat containing 8 VRAC subunit A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrrc8a"
      },
      {
        "slug": "lyst",
        "symbol": "LYST",
        "hgnc": "HGNC:1968",
        "name": "lysosomal trafficking regulator",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lyst"
      },
      {
        "slug": "man2b1",
        "symbol": "MAN2B1",
        "hgnc": "HGNC:6826",
        "name": "mannosidase alpha class 2B member 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/man2b1"
      },
      {
        "slug": "myd88",
        "symbol": "MYD88",
        "hgnc": "HGNC:7562",
        "name": "MYD88 innate immune signal transduction adaptor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myd88"
      },
      {
        "slug": "parn",
        "symbol": "PARN",
        "hgnc": "HGNC:8609",
        "name": "poly(A)-specific ribonuclease",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/parn"
      },
      {
        "slug": "pik3cd",
        "symbol": "PIK3CD",
        "hgnc": "HGNC:8977",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pik3cd"
      },
      {
        "slug": "pik3r1",
        "symbol": "PIK3R1",
        "hgnc": "HGNC:8979",
        "name": "phosphoinositide-3-kinase regulatory subunit 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pik3r1"
      },
      {
        "slug": "pole",
        "symbol": "POLE",
        "hgnc": "HGNC:9177",
        "name": "DNA polymerase epsilon, catalytic subunit",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pole"
      },
      {
        "slug": "rab27a",
        "symbol": "RAB27A",
        "hgnc": "HGNC:9766",
        "name": "RAB27A, member RAS oncogene family",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab27a"
      },
      {
        "slug": "rac2",
        "symbol": "RAC2",
        "hgnc": "HGNC:9802",
        "name": "Rac family small GTPase 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rac2"
      },
      {
        "slug": "rnf168",
        "symbol": "RNF168",
        "hgnc": "HGNC:26661",
        "name": "ring finger protein 168",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rnf168"
      },
      {
        "slug": "rreb1",
        "symbol": "RREB1",
        "hgnc": "HGNC:10449",
        "name": "ras responsive element binding protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rreb1"
      },
      {
        "slug": "rtel1",
        "symbol": "RTEL1",
        "hgnc": "HGNC:15888",
        "name": "regulator of telomere elongation helicase 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rtel1"
      },
      {
        "slug": "sec24c",
        "symbol": "SEC24C",
        "hgnc": "HGNC:10705",
        "name": "SEC24 homolog C, COPII component",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sec24c"
      },
      {
        "slug": "skic2",
        "symbol": "SKIC2",
        "hgnc": "HGNC:10898",
        "name": "SKI2 subunit of superkiller complex",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/skic2"
      },
      {
        "slug": "skic3",
        "symbol": "SKIC3",
        "hgnc": "HGNC:23639",
        "name": "SKI3 subunit of superkiller complex",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/skic3"
      },
      {
        "slug": "spi1",
        "symbol": "SPI1",
        "hgnc": "HGNC:11241",
        "name": "Spi-1 proto-oncogene",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spi1"
      },
      {
        "slug": "tbx1",
        "symbol": "TBX1",
        "hgnc": "HGNC:11592",
        "name": "T-box transcription factor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx1"
      },
      {
        "slug": "tcf3",
        "symbol": "TCF3",
        "hgnc": "HGNC:11633",
        "name": "transcription factor 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcf3"
      },
      {
        "slug": "terc",
        "symbol": "TERC",
        "hgnc": "HGNC:11727",
        "name": "telomerase RNA component",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/terc"
      },
      {
        "slug": "tert",
        "symbol": "TERT",
        "hgnc": "HGNC:11730",
        "name": "telomerase reverse transcriptase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tert"
      },
      {
        "slug": "tinf2",
        "symbol": "TINF2",
        "hgnc": "HGNC:11824",
        "name": "TERF1 interacting nuclear factor 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tinf2"
      },
      {
        "slug": "ufd1",
        "symbol": "UFD1",
        "hgnc": "HGNC:12520",
        "name": "ubiquitin recognition factor in ER associated degradation 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ufd1"
      },
      {
        "slug": "uhrf1",
        "symbol": "UHRF1",
        "hgnc": "HGNC:12556",
        "name": "ubiquitin like with PHD and ring finger domains 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uhrf1"
      },
      {
        "slug": "was",
        "symbol": "WAS",
        "hgnc": "HGNC:12731",
        "name": "WASP actin nucleation promoting factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/was"
      },
      {
        "slug": "xiap",
        "symbol": "XIAP",
        "hgnc": "HGNC:592",
        "name": "X-linked inhibitor of apoptosis",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/xiap"
      },
      {
        "slug": "zbtb24",
        "symbol": "ZBTB24",
        "hgnc": "HGNC:21143",
        "name": "zinc finger and BTB domain containing 24",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/zbtb24"
      },
      {
        "slug": "ada2",
        "symbol": "ADA2",
        "hgnc": "HGNC:1839",
        "name": "adenosine deaminase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ada2"
      },
      {
        "slug": "afg2a",
        "symbol": "AFG2A",
        "hgnc": "HGNC:18119",
        "name": "AAA ATPase AFG2A",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/afg2a"
      },
      {
        "slug": "atrx",
        "symbol": "ATRX",
        "hgnc": "HGNC:886",
        "name": "ATRX chromatin remodeler",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atrx"
      },
      {
        "slug": "braf",
        "symbol": "BRAF",
        "hgnc": "HGNC:1097",
        "name": "B-Raf proto-oncogene, serine/threonine kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/braf"
      },
      {
        "slug": "ccdc47",
        "symbol": "CCDC47",
        "hgnc": "HGNC:24856",
        "name": "coiled-coil domain containing 47",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc47"
      },
      {
        "slug": "cd28",
        "symbol": "CD28",
        "hgnc": "HGNC:1653",
        "name": "CD28 molecule",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd28"
      },
      {
        "slug": "cdh23",
        "symbol": "CDH23",
        "hgnc": "HGNC:13733",
        "name": "cadherin related 23",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdh23"
      },
      {
        "slug": "chd1",
        "symbol": "CHD1",
        "hgnc": "HGNC:1915",
        "name": "chromodomain helicase DNA binding protein 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/chd1"
      },
      {
        "slug": "cplx1",
        "symbol": "CPLX1",
        "hgnc": "HGNC:2309",
        "name": "complexin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cplx1"
      },
      {
        "slug": "ctbp1",
        "symbol": "CTBP1",
        "hgnc": "HGNC:2494",
        "name": "C-terminal binding protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctbp1"
      },
      {
        "slug": "ctla4",
        "symbol": "CTLA4",
        "hgnc": "HGNC:2505",
        "name": "cytotoxic T-lymphocyte associated protein 4",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ctla4"
      },
      {
        "slug": "fgfrl1",
        "symbol": "FGFRL1",
        "hgnc": "HGNC:3693",
        "name": "fibroblast growth factor receptor like 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfrl1"
      },
      {
        "slug": "letm1",
        "symbol": "LETM1",
        "hgnc": "HGNC:6556",
        "name": "leucine zipper and EF-hand containing transmembrane protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/letm1"
      },
      {
        "slug": "mbtps2",
        "symbol": "MBTPS2",
        "hgnc": "HGNC:15455",
        "name": "membrane bound transcription factor peptidase, site 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mbtps2"
      },
      {
        "slug": "mmut",
        "symbol": "MMUT",
        "hgnc": "HGNC:7526",
        "name": "methylmalonyl-CoA mutase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmut"
      },
      {
        "slug": "nr3c1",
        "symbol": "NR3C1",
        "hgnc": "HGNC:7978",
        "name": "nuclear receptor subfamily 3 group C member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr3c1"
      },
      {
        "slug": "nsd2",
        "symbol": "NSD2",
        "hgnc": "HGNC:12766",
        "name": "nuclear receptor binding SET domain protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsd2"
      },
      {
        "slug": "pi4ka",
        "symbol": "PI4KA",
        "hgnc": "HGNC:8983",
        "name": "phosphatidylinositol 4-kinase alpha",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pi4ka"
      },
      {
        "slug": "rnu6atac",
        "symbol": "RNU6ATAC",
        "hgnc": "HGNC:34017",
        "name": "RNA, U6atac small nuclear",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu6atac"
      },
      {
        "slug": "tnfrsf1b",
        "symbol": "TNFRSF1B",
        "hgnc": "HGNC:11917",
        "name": "TNF receptor superfamily member 1B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf1b"
      },
      {
        "slug": "top2b",
        "symbol": "TOP2B",
        "hgnc": "HGNC:11990",
        "name": "DNA topoisomerase II beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/top2b"
      },
      {
        "slug": "tp53",
        "symbol": "TP53",
        "hgnc": "HGNC:11998",
        "name": "tumor protein p53",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp53"
      },
      {
        "slug": "ttc7a",
        "symbol": "TTC7A",
        "hgnc": "HGNC:19750",
        "name": "tetratricopeptide repeat domain 7A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttc7a"
      },
      {
        "slug": "usp48",
        "symbol": "USP48",
        "hgnc": "HGNC:18533",
        "name": "ubiquitin specific peptidase 48",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/usp48"
      },
      {
        "slug": "usp8",
        "symbol": "USP8",
        "hgnc": "HGNC:12631",
        "name": "ubiquitin specific peptidase 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/usp8"
      },
      {
        "slug": "alg1",
        "symbol": "ALG1",
        "hgnc": "HGNC:18294",
        "name": "ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg1"
      },
      {
        "slug": "bcr",
        "symbol": "BCR",
        "hgnc": "HGNC:1014",
        "name": "BCR activator of RhoGEF and GTPase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcr"
      },
      {
        "slug": "cdc42",
        "symbol": "CDC42",
        "hgnc": "HGNC:1736",
        "name": "cell division cycle 42",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cdc42"
      },
      {
        "slug": "crkl",
        "symbol": "CRKL",
        "hgnc": "HGNC:2363",
        "name": "CRK like proto-oncogene, adaptor protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crkl"
      },
      {
        "slug": "cul4b",
        "symbol": "CUL4B",
        "hgnc": "HGNC:2555",
        "name": "cullin 4B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cul4b"
      },
      {
        "slug": "lmnb2",
        "symbol": "LMNB2",
        "hgnc": "HGNC:6638",
        "name": "lamin B2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmnb2"
      },
      {
        "slug": "mapk1",
        "symbol": "MAPK1",
        "hgnc": "HGNC:6871",
        "name": "mitogen-activated protein kinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mapk1"
      },
      {
        "slug": "meis2",
        "symbol": "MEIS2",
        "hgnc": "HGNC:7001",
        "name": "Meis homeobox 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/meis2"
      },
      {
        "slug": "pogz",
        "symbol": "POGZ",
        "hgnc": "HGNC:18801",
        "name": "pogo transposable element derived with ZNF domain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pogz"
      },
      {
        "slug": "slc46a1",
        "symbol": "SLC46A1",
        "hgnc": "HGNC:30521",
        "name": "solute carrier family 46 member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc46a1"
      },
      {
        "slug": "tbk1",
        "symbol": "TBK1",
        "hgnc": "HGNC:11584",
        "name": "TANK binding kinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbk1"
      },
      {
        "slug": "ticam1",
        "symbol": "TICAM1",
        "hgnc": "HGNC:18348",
        "name": "TIR domain containing adaptor molecule 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ticam1"
      },
      {
        "slug": "tlr3",
        "symbol": "TLR3",
        "hgnc": "HGNC:11849",
        "name": "toll like receptor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tlr3"
      },
      {
        "slug": "traf3",
        "symbol": "TRAF3",
        "hgnc": "HGNC:12033",
        "name": "TNF receptor associated factor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/traf3"
      },
      {
        "slug": "unc93b1",
        "symbol": "UNC93B1",
        "hgnc": "HGNC:13481",
        "name": "unc-93B1 regulator of TLR signaling",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc93b1"
      },
      {
        "slug": "znf699",
        "symbol": "ZNF699",
        "hgnc": "HGNC:24750",
        "name": "zinc finger protein 699",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf699"
      },
      {
        "slug": "amn",
        "symbol": "AMN",
        "hgnc": "HGNC:14604",
        "name": "amnion associated transmembrane protein",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/amn"
      },
      {
        "slug": "cubn",
        "symbol": "CUBN",
        "hgnc": "HGNC:2548",
        "name": "cubilin",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cubn"
      },
      {
        "slug": "dnajc21",
        "symbol": "DNAJC21",
        "hgnc": "HGNC:27030",
        "name": "DnaJ heat shock protein family (Hsp40) member C21",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajc21"
      },
      {
        "slug": "efl1",
        "symbol": "EFL1",
        "hgnc": "HGNC:25789",
        "name": "elongation factor like GTPase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/efl1"
      },
      {
        "slug": "sbds",
        "symbol": "SBDS",
        "hgnc": "HGNC:19440",
        "name": "SBDS ribosome maturation factor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sbds"
      },
      {
        "slug": "aicda",
        "symbol": "AICDA",
        "hgnc": "HGNC:13203",
        "name": "activation induced cytidine deaminase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aicda"
      },
      {
        "slug": "bcl10",
        "symbol": "BCL10",
        "hgnc": "HGNC:989",
        "name": "BCL10 immune signaling adaptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcl10"
      },
      {
        "slug": "card9",
        "symbol": "CARD9",
        "hgnc": "HGNC:16391",
        "name": "caspase recruitment domain family member 9",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/card9"
      },
      {
        "slug": "cd247",
        "symbol": "CD247",
        "hgnc": "HGNC:1677",
        "name": "CD247 molecule",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd247"
      },
      {
        "slug": "cd3g",
        "symbol": "CD3G",
        "hgnc": "HGNC:1675",
        "name": "CD3 gamma subunit of T-cell receptor complex",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd3g"
      },
      {
        "slug": "cd40",
        "symbol": "CD40",
        "hgnc": "HGNC:11919",
        "name": "CD40 molecule",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd40"
      },
      {
        "slug": "cd40lg",
        "symbol": "CD40LG",
        "hgnc": "HGNC:11935",
        "name": "CD40 ligand",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd40lg"
      },
      {
        "slug": "ctps1",
        "symbol": "CTPS1",
        "hgnc": "HGNC:2519",
        "name": "CTP synthase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctps1"
      },
      {
        "slug": "cyba",
        "symbol": "CYBA",
        "hgnc": "HGNC:2577",
        "name": "cytochrome b-245 alpha chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyba"
      },
      {
        "slug": "cybb",
        "symbol": "CYBB",
        "hgnc": "HGNC:2578",
        "name": "cytochrome b-245 beta chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cybb"
      },
      {
        "slug": "epg5",
        "symbol": "EPG5",
        "hgnc": "HGNC:29331",
        "name": "ectopic P-granules 5 autophagy tethering factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epg5"
      },
      {
        "slug": "fcgr3a",
        "symbol": "FCGR3A",
        "hgnc": "HGNC:3619",
        "name": "Fc gamma receptor IIIa",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fcgr3a"
      },
      {
        "slug": "icos",
        "symbol": "ICOS",
        "hgnc": "HGNC:5351",
        "name": "inducible T cell costimulator",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/icos"
      },
      {
        "slug": "ifngr1",
        "symbol": "IFNGR1",
        "hgnc": "HGNC:5439",
        "name": "interferon gamma receptor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ifngr1"
      },
      {
        "slug": "ifngr2",
        "symbol": "IFNGR2",
        "hgnc": "HGNC:5440",
        "name": "interferon gamma receptor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ifngr2"
      },
      {
        "slug": "ikbkb",
        "symbol": "IKBKB",
        "hgnc": "HGNC:5960",
        "name": "inhibitor of nuclear factor kappa B kinase subunit beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ikbkb"
      },
      {
        "slug": "il12b",
        "symbol": "IL12B",
        "hgnc": "HGNC:5970",
        "name": "interleukin 12B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il12b"
      },
      {
        "slug": "il21r",
        "symbol": "IL21R",
        "hgnc": "HGNC:6006",
        "name": "interleukin 21 receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il21r"
      },
      {
        "slug": "il2ra",
        "symbol": "IL2RA",
        "hgnc": "HGNC:6008",
        "name": "interleukin 2 receptor subunit alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il2ra"
      },
      {
        "slug": "il2rb",
        "symbol": "IL2RB",
        "hgnc": "HGNC:6009",
        "name": "interleukin 2 receptor subunit beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il2rb"
      },
      {
        "slug": "irf7",
        "symbol": "IRF7",
        "hgnc": "HGNC:6122",
        "name": "interferon regulatory factor 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf7"
      },
      {
        "slug": "irf8",
        "symbol": "IRF8",
        "hgnc": "HGNC:5358",
        "name": "interferon regulatory factor 8",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/irf8"
      },
      {
        "slug": "isg15",
        "symbol": "ISG15",
        "hgnc": "HGNC:4053",
        "name": "ISG15 ubiquitin like modifier",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/isg15"
      },
      {
        "slug": "ivns1abp",
        "symbol": "IVNS1ABP",
        "hgnc": "HGNC:16951",
        "name": "influenza virus NS1A binding protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ivns1abp"
      },
      {
        "slug": "lat",
        "symbol": "LAT",
        "hgnc": "HGNC:18874",
        "name": "linker for activation of T cells",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lat"
      },
      {
        "slug": "lrba",
        "symbol": "LRBA",
        "hgnc": "HGNC:1742",
        "name": "LPS responsive beige-like anchor protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrba"
      },
      {
        "slug": "magt1",
        "symbol": "MAGT1",
        "hgnc": "HGNC:28880",
        "name": "magnesium transporter 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/magt1"
      },
      {
        "slug": "myc",
        "symbol": "MYC",
        "hgnc": "HGNC:7553",
        "name": "MYC proto-oncogene, bHLH transcription factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myc"
      },
      {
        "slug": "ncf1",
        "symbol": "NCF1",
        "hgnc": "HGNC:7660",
        "name": "neutrophil cytosolic factor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ncf1"
      },
      {
        "slug": "ncf2",
        "symbol": "NCF2",
        "hgnc": "HGNC:7661",
        "name": "neutrophil cytosolic factor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ncf2"
      },
      {
        "slug": "nfe2l2",
        "symbol": "NFE2L2",
        "hgnc": "HGNC:7782",
        "name": "NFE2 like bZIP transcription factor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfe2l2"
      },
      {
        "slug": "orai1",
        "symbol": "ORAI1",
        "hgnc": "HGNC:25896",
        "name": "ORAI calcium release-activated calcium modulator 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/orai1"
      },
      {
        "slug": "otulin",
        "symbol": "OTULIN",
        "hgnc": "HGNC:25118",
        "name": "OTU deubiquitinase with linear linkage specificity",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otulin"
      },
      {
        "slug": "pgm3",
        "symbol": "PGM3",
        "hgnc": "HGNC:8907",
        "name": "phosphoglucomutase 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pgm3"
      },
      {
        "slug": "prps1",
        "symbol": "PRPS1",
        "hgnc": "HGNC:9462",
        "name": "phosphoribosyl pyrophosphate synthetase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prps1"
      },
      {
        "slug": "pstpip1",
        "symbol": "PSTPIP1",
        "hgnc": "HGNC:9580",
        "name": "proline-serine-threonine phosphatase interacting protein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pstpip1"
      },
      {
        "slug": "rbck1",
        "symbol": "RBCK1",
        "hgnc": "HGNC:15864",
        "name": "RANBP2-type and C3HC4-type zinc finger containing 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbck1"
      },
      {
        "slug": "sh2d1a",
        "symbol": "SH2D1A",
        "hgnc": "HGNC:10820",
        "name": "SH2 domain containing 1A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sh2d1a"
      },
      {
        "slug": "sp110",
        "symbol": "SP110",
        "hgnc": "HGNC:5401",
        "name": "SP110 nuclear body protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sp110"
      },
      {
        "slug": "tfrc",
        "symbol": "TFRC",
        "hgnc": "HGNC:11763",
        "name": "transferrin receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tfrc"
      },
      {
        "slug": "tnfrsf4",
        "symbol": "TNFRSF4",
        "hgnc": "HGNC:11918",
        "name": "TNF receptor superfamily member 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf4"
      },
      {
        "slug": "tyk2",
        "symbol": "TYK2",
        "hgnc": "HGNC:12440",
        "name": "tyrosine kinase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tyk2"
      },
      {
        "slug": "unc119",
        "symbol": "UNC119",
        "hgnc": "HGNC:12565",
        "name": "unc-119 lipid binding chaperone",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc119"
      },
      {
        "slug": "ung",
        "symbol": "UNG",
        "hgnc": "HGNC:12572",
        "name": "uracil DNA glycosylase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ung"
      },
      {
        "slug": "xrcc4",
        "symbol": "XRCC4",
        "hgnc": "HGNC:12831",
        "name": "X-ray repair cross complementing 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xrcc4"
      }
    ]
  }
}