{
  "url": "https://dantelabs.com/traits/hypergranulosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "hypergranulosis",
    "id": "HP:0025114",
    "name": "Hypergranulosis",
    "definition": "Hypergranulosis is an increased thickness of the stratum granulosum.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "epidermal-thickening",
        "name": "Epidermal thickening",
        "url": "https://dantelabs.com/traits/epidermal-thickening"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "dsg1",
        "symbol": "DSG1",
        "hgnc": "HGNC:3048",
        "name": "desmoglein 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dsg1"
      },
      {
        "slug": "gja1",
        "symbol": "GJA1",
        "hgnc": "HGNC:4274",
        "name": "gap junction protein alpha 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja1"
      },
      {
        "slug": "krt10",
        "symbol": "KRT10",
        "hgnc": "HGNC:6413",
        "name": "keratin 10",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt10"
      },
      {
        "slug": "lipn",
        "symbol": "LIPN",
        "hgnc": "HGNC:23452",
        "name": "lipase family member N",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lipn"
      },
      {
        "slug": "sdr9c7",
        "symbol": "SDR9C7",
        "hgnc": "HGNC:29958",
        "name": "short chain dehydrogenase/reductase family 9C member 7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdr9c7"
      },
      {
        "slug": "spink5",
        "symbol": "SPINK5",
        "hgnc": "HGNC:15464",
        "name": "serine peptidase inhibitor Kazal type 5",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/spink5"
      },
      {
        "slug": "atp2a2",
        "symbol": "ATP2A2",
        "hgnc": "HGNC:812",
        "name": "ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp2a2"
      },
      {
        "slug": "aagab",
        "symbol": "AAGAB",
        "hgnc": "HGNC:25662",
        "name": "alpha and gamma adaptin binding protein",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/aagab"
      },
      {
        "slug": "ccdc91",
        "symbol": "CCDC91",
        "hgnc": "HGNC:24855",
        "name": "coiled-coil domain containing 91",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc91"
      },
      {
        "slug": "col14a1",
        "symbol": "COL14A1",
        "hgnc": "HGNC:2191",
        "name": "collagen type XIV alpha 1 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col14a1"
      },
      {
        "slug": "loricrin",
        "symbol": "LORICRIN",
        "hgnc": "HGNC:6663",
        "name": "loricrin cornified envelope precursor protein",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/loricrin"
      },
      {
        "slug": "krt1",
        "symbol": "KRT1",
        "hgnc": "HGNC:6412",
        "name": "keratin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt1"
      },
      {
        "slug": "krt16",
        "symbol": "KRT16",
        "hgnc": "HGNC:6423",
        "name": "keratin 16",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt16"
      },
      {
        "slug": "krt9",
        "symbol": "KRT9",
        "hgnc": "HGNC:6447",
        "name": "keratin 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt9"
      },
      {
        "slug": "alox12b",
        "symbol": "ALOX12B",
        "hgnc": "HGNC:430",
        "name": "arachidonate 12-lipoxygenase, 12R type",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alox12b"
      },
      {
        "slug": "aloxe3",
        "symbol": "ALOXE3",
        "hgnc": "HGNC:13743",
        "name": "arachidonate epidermal lipoxygenase 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aloxe3"
      },
      {
        "slug": "card14",
        "symbol": "CARD14",
        "hgnc": "HGNC:16446",
        "name": "caspase recruitment domain family member 14",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/card14"
      },
      {
        "slug": "cers3",
        "symbol": "CERS3",
        "hgnc": "HGNC:23752",
        "name": "ceramide synthase 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cers3"
      },
      {
        "slug": "enpp1",
        "symbol": "ENPP1",
        "hgnc": "HGNC:3356",
        "name": "ectonucleotide pyrophosphatase/phosphodiesterase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/enpp1"
      },
      {
        "slug": "gjb3",
        "symbol": "GJB3",
        "hgnc": "HGNC:4285",
        "name": "gap junction protein beta 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjb3"
      },
      {
        "slug": "pnpla1",
        "symbol": "PNPLA1",
        "hgnc": "HGNC:21246",
        "name": "patatin like domain 1, omega-hydroxyceramide transacylase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pnpla1"
      },
      {
        "slug": "poglut1",
        "symbol": "POGLUT1",
        "hgnc": "HGNC:22954",
        "name": "protein O-glucosyltransferase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/poglut1"
      },
      {
        "slug": "serpinb7",
        "symbol": "SERPINB7",
        "hgnc": "HGNC:13902",
        "name": "serpin family B member 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serpinb7"
      },
      {
        "slug": "wnt10a",
        "symbol": "WNT10A",
        "hgnc": "HGNC:13829",
        "name": "Wnt family member 10A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt10a"
      }
    ]
  }
}